Abstract:
:The ability to understand speech under adverse listening conditions deteriorates with age. In addition to genuine hearing deficits, age-related declines in attentional and inhibitory control are assumed to contribute to these difficulties. Here, the impact of task-irrelevant distractors on speech perception was studied in 28 younger and 24 older participants in a simulated "cocktail party" scenario. In a two-alternative forced-choice word discrimination task, the participants responded to a rapid succession of short speech stimuli ("on" and "off") that was presented at a frequent standard location or at a rare deviant location in silence or with a concurrent distractor speaker. Behavioral responses and event-related potentials (mismatch negativity MMN, P3a, and reorienting negativity RON) were analyzed to study the interplay of distraction, orientation, and refocusing in the presence of changes in target location. While shifts in target location decreased performance of both age groups, this effect was more pronounced in the older group. Especially in the distractor condition, the electrophysiological measures indicated a delayed attention capture and a delayed re-focussing of attention toward the task-relevant stimulus feature in the older group, relative to the young group. In sum, the results suggest that a delay in the attention switching mechanism contribute to the age-related difficulties in speech perception in dynamic listening situations with multiple speakers.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Getzmann S,Falkenstein M,Wascher Edoi
10.1016/j.bbr.2014.10.026subject
Has Abstractpub_date
2015-02-01 00:00:00pages
435-45eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00691-3journal_volume
278pub_type
杂志文章abstract::Social isolation rearing (isolated condition, IC) is used as a model of early life stress in rodents. Rats raised in this condition are often compared to rats raised in an environmentally enriched condition (EC). However, EC rats are repeatedly exposed to forced novelty, another classic stressor in rodents. These stud...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.01.049
更新日期:2015-04-15 00:00:00
abstract::A rat model of novelty-seeking phenotype predicts vulnerability to nicotine relapse where locomotor reactivity to novelty is used to rank high (HR) versus low (LR) responders. Present study investigates implication of cannabinoid receptor 1 (CB1R) in the basolateral (BLA) and the central (CeA) nuclei of amygdala in be...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.11.015
更新日期:2012-03-01 00:00:00
abstract::Rats with hippocampal aspiration lesions or cortical control lesions were compared to sham operated controls in a trace conditioned suppression task, in which a long-lasting background stimulus played the role of more conventional contextual cues. In all three surgical treatment groups, conditioning to the explicit co...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00104-6
更新日期:1998-03-01 00:00:00
abstract::Although drug rewards and natural rewards share neural substrates, the neuronal activation patterns and mechanisms behind the interaction between cocaine and social reward are poorly understood. Here, we investigated the conditioned place preference (CPP) in social (conspecific) vs cocaine conditioning, and the expres...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.05.010
更新日期:2016-09-01 00:00:00
abstract::Previous studies have suggested that ethanol exposure during brain development affects responses to fear and anxiety after maturity. To clarify in detail the impaired behavior related to fear and anxiety seen in rat offspring prenatally exposed to ethanol, their behaviors were observed using an elevated T-maze (ETM) t...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.07.001
更新日期:2012-10-01 00:00:00
abstract::The present study was aimed to determine how direct injections into the lateral septum (LS) of muscimol and baclofen, GABAA and GABAB receptor agonists, respectively, affect intake of 10% sucrose and sucrose licking activity in rats. The effects of muscimol and baclofen on the 1-h intake of sucrose and sucrose licking...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.07.035
更新日期:2014-10-15 00:00:00
abstract::Brain microdialysis has been used to examine the in vivo effects of potassium and calcium on dopamine release in the dorsal globus pallidus (GP) of rats. Furthermore, the effects of food presentation and consumption on dopamine release in the GP were investigated. Basal dopamine levels in the GP were below the detecti...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(99)00197-7
更新日期:2000-06-15 00:00:00
abstract::Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00273-5
更新日期:2003-03-18 00:00:00
abstract:BACKGROUND:According to the incentive sensitization theory, addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems. After repeated ethanol administration, some animals develop psychomotor sensitization, a phenomenon which occurs simultaneously with the incentive sensitization...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.09.015
更新日期:2013-11-01 00:00:00
abstract::Stress and antidepressant treatment can modulate DNA methylation in promoter region of genes related to neuroplasticity and mood regulation, thus implicating this epigenetic mechanism in depression neurobiology and treatment. Accordingly, systemic administration of DNA methyltransferase (DNMT) inhibitors induces antid...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.01.022
更新日期:2018-05-02 00:00:00
abstract::We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-isc...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00287-4
更新日期:2001-01-08 00:00:00
abstract::Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on four sessions of instrumental avoidance conditioning, during which an eyeblink (EB) response during the presentation of a tone-conditioned stimulus prevented the occurrence of a paraor...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90103-1
更新日期:1994-12-15 00:00:00
abstract::This study examined visual discrimination performance in a sample of older adults before, during and post treadmill walking at preferred walking speed and preferred walking speed +20%. Nine adults (6 females and 3 males) aged 60-77 years (mean age=67.1±5.7 years) undertook three trials each lasting 15 min, rest, walki...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.020
更新日期:2016-04-01 00:00:00
abstract::Environmental enrichment (EE) at early stages of neurodevelopment attenuates HI-induced behavioral, histological and cellular damage. However, the effects of EE exposure during gestational or early postnatal period and the possible influence of sexual dimorphism on EE protection are not fully understood. Present study...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.11.036
更新日期:2019-02-01 00:00:00
abstract::Alzheimer's disease (AD), can be described as a vascular disorder, is characterized by endothelial and platelet activation. One feature of activated cells is loss of lipid asymmetry, and membrane blebbing which cause microparticle (MP) formation. MPs increased under many pathological states and little information is a...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.09.019
更新日期:2013-11-01 00:00:00
abstract::Neurological disorders are a major cause of chronic disability globally among which stroke is a leading cause of chronic disability. The advances in the medical management of stroke patients over the past decade have significantly reduced mortality, but at the same time increased numbers of disabled survivors. Unfortu...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2016.08.029
更新日期:2018-03-15 00:00:00
abstract::Research investigating how control over stressors affects behavior often utilizes freezing and shuttle escape learning as the behavioral endpoints. These endpoints have been argued to reflect anxious or depressed states, but these descriptions are problematic. The present study sought to determine the impact of stress...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.04.024
更新日期:2008-11-03 00:00:00
abstract::Several recent models of episodic memory have highlighted a potential contribution from the head-direction system; there is, however, surprisingly little known about the behavioural effects of selective lesions within the head-direction system. To address this issue, and determine what aspects of spatial memory are de...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.05.033
更新日期:2011-10-10 00:00:00
abstract::The exposure to stress has been associated with increased depressive and anxiety symptoms, yet not all individuals respond negatively to the experience of stress. Recent rodent social defeat models demonstrate similar individual differences in response to social stress. In particular, mice subjected to chronic social ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.09.009
更新日期:2013-11-01 00:00:00
abstract::Effective emotion regulation in stressful contexts is a key feature of mental health. Acute stress, however, impairs prefrontal top-down control, probably leading to a decline of emotion regulatory capacities. By contrast, the delayed cortisol increase in response to a stressor or after a pharmacological manipulation ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.03.049
更新日期:2019-11-18 00:00:00
abstract::There is evidence that early deprivation of vision prompts the use of body-based, egocentric spatial representations in congenitally blind individuals, whereas previous visual experience favors the use of object-based, allocentric representations (e.g. Pasqualotto A, Spiller MJ, Jansari AS, Proulx MJ. Visual experienc...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.07.032
更新日期:2014-10-15 00:00:00
abstract::Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.06.008
更新日期:2018-10-01 00:00:00
abstract::Cancer patients often suffer long-lasting affective and cognitive impairments as a result of chemotherapy treatment. Previous work in our lab has shown deficits in learning and memory and hippocampal cell proliferation in mice lasting up to 20 weeks following acute administration of thioTEPA. In this study, the effect...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.08.046
更新日期:2013-01-01 00:00:00
abstract::Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2-4h of isoflurane anesthetic without surgical trauma can also impair cognitive function. We aimed ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.032
更新日期:2016-04-15 00:00:00
abstract::Anxiety is a growing public health concern that has been shown to impair both sleep and learning, and these associations have been extensively studied in recent years. In the rodent model, oftentimes various foot-shock paradigms are employed to induce stress, and subsequent sleep recordings and/or learning task result...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.03.065
更新日期:2011-09-23 00:00:00
abstract::Unilateral removals of the posterior insula or of the second somatic sensory projection area (SII) were made in respectively 8 and 6 monkeys. These animals were divided into a 'contralateral' group of 7 with removals from the hemisphere opposite to the preferred hand; and an 'ipsilateral' group of 7 animals with remov...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(87)90011-8
更新日期:1987-10-01 00:00:00
abstract::Pairing of the stimulus to the cerebral peduncle (CP) with that to the forearm skin leads cats to flex their forearms within a 10-day training period in response to stimulus to CP, which was initially ineffective. Behavioral study and extracellular unit analysis suggested that the cellular mechanism for this condition...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90094-0
更新日期:1988-04-01 00:00:00
abstract::The effect of intraseptal injections of lidocaine before a first or a second session in the elevated plus-maze, in a test-retest paradigm, was investigated. In addition to gross session analyses, a minute-by-minute analysis of the sessions was used to evaluate both anxiety and memory. Lidocaine injections before the t...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.02.011
更新日期:2010-06-26 00:00:00
abstract::Previous studies suggest an interaction between the level of physical activity and diet preference. However, this relationship has not been well characterized for sex differences that may exist. The present study examined the influence of sex on diet preference in male and female Wistar rats that were housed under eit...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.07.018
更新日期:2017-09-15 00:00:00
abstract::The complex bidirectional communication between the central nervous system and the peripheral immune system is of possible relevance for both normal brain functions and the development of psychiatric disorders. The aim of this investigation was to study central expression of inflammatory markers in a genetic rat model...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.09.025
更新日期:2015-03-15 00:00:00