Abstract：
:The recently developed technique for measuring cutaneous mitochondrial oxygen tension (mitoPO2) by means of the Protoporphyrin IX-Triplet State Lifetime Technique (PpIX-TSLT) provides new opportunities for assessing mitochondrial function in vivo. The aims of this work were to study whether cutaneous mitochondrial measurements reflect mitochondrial status in other parts of the body and to demonstrate the feasibility of the technique for potential clinical use. The first part of this paper demonstrates a correlation between alterations in mitochondrial parameters in skin and other tissues during endotoxemia. Experiments were performed in rats in which mitochondrial dysfunction was induced by a lipopolysaccharide-induced sepsis (n = 5) and a time control group (n = 5). MitoPO2 and mitochondrial oxygen consumption (mitoVO2) were measured using PpIX-TSLT in skin, liver and buccal mucosa of the mouth. Both skin and buccal mucosa show a significant mitoPO2-independent decrease (P < 0.05) in mitoVO2 after LPS infusion (a decrease of 37 and 39% respectively). In liver both mitoPO2 and mitoVO2 decreased significantly (33 and 27% respectively). The second part of this paper describes the clinical concept of monitoring cutaneous mitochondrial respiration in man. A first prototype of a clinical PpIX-TSLT monitor is described and its usability is demonstrated on human skin. We expect that clinical implementation of this device will greatly contribute to our understanding of mitochondrial oxygenation and oxygen metabolism in perioperative medicine and in critical illness. Our ultimate goal is to develop a clinical monitor for mitochondrial function and the current results are an important step forward.
journal_name
J Clin Monit Computjournal_title
Journal of clinical monitoring and computingauthors
Harms FA,Bodmer SI,Raat NJ,Mik EGdoi
10.1007/s10877-014-9628-9subject
Has Abstractpub_date
2015-08-01 00:00:00pages
509-19issue
4eissn
1387-1307issn
1573-2614journal_volume
29pub_type
杂志文章abstract：:We know that a 10 cm departure from the reference level of pressure transducer position is equal to a 7.5 mmHg change of invasive hemodynamic pressure monitoring in a fluid-filled system. However, the relationship between the site level of a variable arterial pressure transducer and the pulse contour-derived parameter...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-015-9756-x
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:Optimizing cerebral oxygenation is of paramount importance in certain intraoperative situations. There is, however, a paucity of published data pertaining to changes in cerebral oxygenation seen with increases in the inspired fraction of oxygen (FIO2) or end-tidal carbon dioxide (PETCO2) in anesthetized pati...
journal_title：Journal of clinical monitoring and computing
pub_type： 临床试验,杂志文章
doi：10.1007/s10877-010-9265-x
更新日期：2010-12-01 00:00:00
abstract：:Uncalibrated arterial waveform analysis enables dynamic preload assessment in a minimally invasive fashion. Evidence about the validity of the technique in patients with impaired left ventricular function is scarce, while adequate cardiac preload assessment would be of great value in these patients. The aim of this st...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-015-9743-2
更新日期：2016-08-01 00:00:00
abstract：:The composite auditory evoked potentials index (cAAI) uses both cortical electroencephalogram (EEG) and response to auditory stimuli, while the bispectral index (BIS) uses only the cortical EEG and auditory evoked potentials index (AAI) uses only response to auditory stimuli. We expected that the cAAI was more useful ...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10877-013-9441-x
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:Ventilator-associated pneumonia (VAP) is a common hazardous complication in ICU patients. The aim of the current review is to give an update on the current status and future recommendations for VAP prevention. METHODS:This article gives an updated review of the current literature on VAP. The first part brief...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10877-010-9228-2
更新日期：2010-04-01 00:00:00
abstract：:Currently, there are plenty of videolaryngoscopes that appear on the market. They have different specifications. Some of these features favor the fact that they are more suited for educational purposes of future operators and others can be characterized with an excellent clinical use. In this study we compared four ty...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-015-9727-2
更新日期：2016-08-01 00:00:00
abstract：:Central venous cannulation is a commonly preformed procedure in many branches of medicine, particularly in anaesthesia and intensive care medicine. The purpose of this study was to compare the landmark-guided technique to the ultrasound-guided technique for internal jugular vein cannulation in cardiovascular surgery p...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10877-014-9585-3
更新日期：2015-02-01 00:00:00
abstract：:With the AnaConDa™ and the MIRUS™ system, volatile anesthetics can be administered for inhalation sedation in intensive care units. Instead of a circle system, both devices use anesthetic reflectors to save on the anesthetic agent. We studied the efficiency of desflurane reflection with both devices using different ti...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-016-9902-0
更新日期：2018-08-01 00:00:00
abstract：:Aortic peak systolic velocity variation (ΔVpeakAo) is a reliable dynamic indicator of preload in mechanically ventilated children. However, easily measurable alternative parameters like carotid peak systolic velocity variation (ΔVpeakCa) and suprasternal peak systolic velocity variation (ΔVpeakSs) are not well evaluat...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-019-00431-8
更新日期：2020-12-01 00:00:00
abstract：:The eye lens is one of the most sensitive organs for radiation injury and exposure might lead to radiation induced cataract. Eye lens dosimetry in anesthesiology has been published in few clinical trials and an active debate about the causality of radiation induced cataract is still ongoing. Recently, the Internationa...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-016-9857-1
更新日期：2017-04-01 00:00:00
abstract：:Jasiukaitis and Lyon (J Clin Monit Comput, https://doi.org/10.1007/s10877-018-0181-9, 2018) described an motor evoked potential (MEP)amplitude trending system to detect MEP amplitude loss against a background of MEP variability. They found that the end of case value of a running R2 triggered by a set MEP amplitude los...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-019-00272-5
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Describe reproducibility of a measurement method to investigate deficits in eye-head co-ordination. METHODS:Combined recordings of head and eye rotation using wireless motion sensors and electro-oculography (EOG) were used as an initial step towards a method to quantify eye-head co-ordination deficits. Head ...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-009-9160-5
更新日期：2009-02-01 00:00:00
abstract：:Studies reveal that the false alarm rate (FAR) demonstrated by intensive care unit (ICU) vital signs monitors ranges from 0.72 to 0.99. We applied machine learning (ML) to ICU multi-sensor information to imitate a medical specialist in diagnosing patient condition. We hypothesized that applying this data-driven approa...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-019-00307-x
更新日期：2020-04-01 00:00:00
abstract：:Pulmonary air embolism is a well-known consequence of surgery, trauma, diving, and aviation. This article reviews the physiological effects, means of detection and methods of prevention and treatment of pulmonary air embolism. The primary physiological effects are elevated pulmonary artery pressures, increased ventila...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,评审
doi：10.1023/a:1011455701892
更新日期：2000-01-01 00:00:00
abstract：:Recent progress in genomics and experimental biology has brought exponential growth of the biological information available for computational analysis in public genomics databases. However, applying the potentially enormous scientific value of this information to the understanding of biological systems requires comput...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-005-3463-y
更新日期：2005-10-01 00:00:00
abstract：:Pulse contour analysis techniques are used for beat-to-beat tracking of cardiac output in critically ill patients. However, an adequate pulse pressure waveform signal and identification of the appropriate (i.e. systolic) part of the waveform by the monitor are crucial for correct calculation of continuous cardiac outp...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-013-9470-5
更新日期：2013-10-01 00:00:00
abstract：:Intraoperative neurophysiological monitoring (IONM) is widely used in spinal cord tumors (SCTs) removal surgery. This study mainly hypothesized that patients with prolonged latency of preoperative somatosensory evoked potentials (preSEPLat) would have more deteriorated intraoperative evoked potentials. Among 506 patie...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-020-00584-x
更新日期：2020-09-29 00:00:00
abstract：:Unnecessary variation in clinical care and clinical research reduces our ability to determine what healthcare interventions are effective. Reducing this unnecessary variation could lead to further healthcare quality improvement and more effective clinical research. We have developed and used electronic decision suppor...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-012-9356-y
更新日期：2012-08-01 00:00:00
abstract：:Recent advances in technology have brought many kinds of monitoring devices into the operating room (OR). The information gathered by monitors can be channeled to the operating ward information system via a local area network (LAN). Connecting patients to monitors and monitors to the LAN, however, requires a large num...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1023/a:1009911208828
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To demonstrate the usefulness of rectus femoris muscle MEPs monitoring in a paraparetic neuromuscular scoliosis case. METHODS:Multiple monitoring modalities including SEPs, MEPs and EMG were performed for an anterior and posterior correction surgery for a neuromuscular scoliosis patient with no motor and sen...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-011-9325-x
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:We present a new physiological model that discriminated between changes in the systemic arterial and venous circulation. To test our model, we studied the effects of dobutamine and hypovolemia in intact pentabarbital-anesthetized piglets. METHODS:Aorta pressure (Pao), central venous pressure (Pcv), mean syst...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-010-9258-9
更新日期：2010-10-01 00:00:00
abstract：:Electric energy have been in use for the treatment of various ailments, including pain, since the time of Pharaohs. The theoretical basis of electrotherapy of pain was provided by the Gate Control Theory of Melzak and Wall. In 1965, Shealey et al. first introduced electrical stimulation of spinal cord for treating pai...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,评审
doi：10.1007/s10877-009-9201-0
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:Artefact detection is an essential feature of automatic EEG monitoring systems used in anaesthesia. Clinical experience indicates that Narcotrend monitoring (MonitorTechnik, Bad Bramstedt, Germany, version 4.0) excludes more EEG epochs because of artefacts than bispectral index monitoring (BIS, Aspect Medical...
journal_title：Journal of clinical monitoring and computing
pub_type： 临床试验,杂志文章
doi：10.1007/s10877-005-2700-8
更新日期：2004-08-01 00:00:00
abstract：:The aim of this study was to compare the cardiac function index (CFI) and global ejection fraction (GEF) obtained by VolumeView/EV1000™, with the left ventricular ejection fraction (LVEF) by echocardiography in septic shock patients. A prospective observational study was conducted in a medical intensive care unit of a...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-018-0152-1
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:Awareness with recall is a rare but serious complication of general anaesthesia with an incidence ranging from 0.1%-0.7%. In the absence of a reliable depth-of-anaesthesia monitor, attempts have been made to predict awareness from intraoperative haemodynamic monitoring data, with little success. Artificial ne...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1023/a:1015426015547
更新日期：2002-01-01 00:00:00
abstract：:Changes have been made to the AnaConDa device (Sedana Medical, Stockholm, Sweden), decreasing its size to reduce dead space and carbon dioxide (CO2) retention. However, this also involves a decrease in the surface area of the activated carbon filter. The CO2 elimination and sevoflurane (SEV) reflection of the old devi...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-019-00285-0
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:This study evaluates a method for calibrating mainstream CO(2) analysers in which CO(2) partial pressure (P (CO2)) is calculated as a function of the outputs of CO(2) and O(2) analysers. METHODS:Three mass flow controllers were used to generate 25 different reference mixtures of O(2), N(2) and CO(2). Referen...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-005-9005-9
更新日期：2006-04-01 00:00:00
abstract：:Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support sy...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-016-9946-1
更新日期：2017-12-01 00:00:00
abstract：:The use of sedation for diagnostic procedures including gastrointestinal endoscopy is rapidly growing. Recovery of cognitive function after sedation is important because it would be important for most patients to resume safe, normal life soon after the procedure. Computerized tests have shown being accurate descriptor...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-018-0134-3
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Ventricular late potentials (LP) recording with signal-averaged electrocar- diogram allow identifying patients at risk of sudden death and ventricular tachycardia. Cardiac surgery with cardiopulmonary bypass (CPB) could predispose to the development of myocardial ischemia related to imperfect c...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-011-9305-1
更新日期：2011-08-01 00:00:00
