Abstract:
:With the AnaConDa™ and the MIRUS™ system, volatile anesthetics can be administered for inhalation sedation in intensive care units. Instead of a circle system, both devices use anesthetic reflectors to save on the anesthetic agent. We studied the efficiency of desflurane reflection with both devices using different tidal volumes (VT), respiratory rates (RR), and 'patient' concentrations (CPat) in a bench study. A test lung was ventilated with four settings (volume control, RR × VT: 10 × 300 mL, 10 × 500 mL, 20 × 500 mL, 10 × 1000 mL). Two different methods for determination of reflection efficiency were established: First (steady state), a bypass flow carried desflurane into the test lung (flowin), the input concentration (Cin) was varied (1-17 vol%), and the same flow (flowex, Cex) was suctioned from the test lung. After equilibration, CPat was stored online and averaged; efficiency [%] was calculated [Formula: see text]. Second (washout), flowin and flowex were stopped, the decline of CPat was measured; efficiency was calculated from the decay constant of the exponential regression equation. Both measurement methods yielded similar results (Bland-Altman: bias: -0.9 %, accuracy: ±5.55 %). Efficiencies higher than 80 % (>80 % of molecules exhaled are reflected) could be demonstrated in the clinical range of CPat and VT. Efficiency inversely correlates with the product of CPat and VT which can be imagined as the volume of anesthetic vapor exhaled by the patient in one breath, but not with the respiratory frequency. Efficiency of the AnaConDa™ was higher for each setting compared with the MIRUS™. Desflurane is reflected by both reflectors with efficiencies high enough for clinical use.
journal_name
J Clin Monit Computjournal_title
Journal of clinical monitoring and computingauthors
Bomberg H,Wessendorf M,Bellgardt M,Veddeler M,Wagenpfeil S,Volk T,Groesdonk HV,Meiser Adoi
10.1007/s10877-016-9902-0subject
Has Abstractpub_date
2018-08-01 00:00:00pages
605-614issue
4eissn
1387-1307issn
1573-2614pii
10.1007/s10877-016-9902-0journal_volume
32pub_type
杂志文章abstract::Closed loop target-control infusion systems using a Bispectral (BIS) signal as an input (TCI Loop) can automatically maintain intravenous anesthesia in a BIS range of 40-60 %. Our purpose was to assess to what extent such a system could decrease anesthesia workload in comparison to the use of a stand alone TCI system ...
journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,评审
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
doi:10.1007/s10877-018-0165-9
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of clinical monitoring and computing
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pub_type: 杂志文章
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