The evolution of eProtocols that enable reproducible clinical research and care methods.

Abstract:

:Unnecessary variation in clinical care and clinical research reduces our ability to determine what healthcare interventions are effective. Reducing this unnecessary variation could lead to further healthcare quality improvement and more effective clinical research. We have developed and used electronic decision support tools (eProtocols) to reduce unnecessary variation. Our eProtocols have progressed from a locally developed mainframe computer application in one clinical site (LDS Hospital) to web-based applications available in multiple languages and used internationally. We use eProtocol-insulin as an example to illustrate this evolution. We initially developed eProtocol-insulin as a local quality improvement effort to manage stress hyperglycemia in the adult intensive care unit (ICU). We extended eProtocol-insulin use to translate our quality improvement results into usual clinical care at Intermountain Healthcare ICUs. We exported eProtocol-insulin to support research in other US and international institutions, and extended our work to the pediatric ICU. We iteratively refined eProtocol-insulin throughout these transitions, and incorporated new knowledge about managing stress hyperglycemia in the ICU. Based on our experience in the development and clinical use of eProtocols, we outline remaining challenges to eProtocol development, widespread distribution and use, and suggest a process for eProtocol development. Technical and regulatory issues, as well as standardization of protocol development, validation and maintenance, need to be addressed. Resolution of these issues should facilitate general use of eProtocols to improve patient care.

journal_name

J Clin Monit Comput

authors

Blagev DP,Hirshberg EL,Sward K,Thompson BT,Brower R,Truwit J,Hite D,Steingrub J,Orme JF Jr,Clemmer TP,Weaver LK,Thomas F,Grissom CK,Sorenson D,Sittig DF,Wallace CJ,East TD,Warner HR,Morris AH

doi

10.1007/s10877-012-9356-y

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

305-17

issue

4

eissn

1387-1307

issn

1573-2614

journal_volume

26

pub_type

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