Abstract:
:Intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MFC) is acquired gradually, taking 4 or more days to establish. One explanation for this finding is that the stimulation becomes more rewarding with repetition. Four experiments were conducted to test this hypotheses. In Experiment 1, the MFC ICSS frequency thresholds remained constant over the first 3 weeks of testing while the rate of lever pressing response increased. In Experiment 2, it was found that acquisition of MFC ICSS was much more rapid when a motorically simpler response (nose-poking) was employed. Similarly, Experiments 3 and 4 further demonstrated that response factors such as task complexity may ultimately determine the rate of development of frontal cortex ICSS. Overall, these data suggest that independent of the rewarding effects of MFC stimulation there are other effects that initially interfere with learning of complex operant responses.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Corbett D,Silva LR,Stellar JRdoi
10.1016/0031-9384(85)90083-6subject
Has Abstractpub_date
1985-01-01 00:00:00pages
89-95issue
1eissn
0031-9384issn
1873-507Xpii
0031-9384(85)90083-6journal_volume
34pub_type
杂志文章abstract::Leptin is a hormone secreted by adipocytes, which plays an important role in the control of food intake and metabolic processes. In the current study, a dose-dependent relationship was shown between a bolus intracerebroventricular rat recombinant leptin administration and reductions in food intake and body weight in S...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00243-1
更新日期:1999-01-01 00:00:00
abstract::Self-grooming in response to the odors of conspecifics is a form of olfactory communication among meadow voles. The amount of time meadow voles spend self-grooming when they encounter the odors of conspecifics varies seasonally, with males targeting the odors of reproductively active females only during the breeding s...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.05.011
更新日期:2005-07-21 00:00:00
abstract::Sexually dimorphic pheromone pathways have been used successfully to study insect olfactory coding. As one of the few mammalian species with an identified sex pheromone, the domestic pig (Sus scrofa) may be an ideal vertebrate species in which to examine sex differences in olfactory processing of a specific stimulus. ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(94)00225-t
更新日期:1995-02-01 00:00:00
abstract::The instrumental methods to induce paradoxical sleep (PS) deprivation are stressful. The modified multiple platform method (MMPM), in which animals are placed with new cohorts inside the water tanks, results in augmented ACTH and corticosterone (CORT) responses. We hypothesised that this increased response could be at...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(99)00181-x
更新日期:2000-01-01 00:00:00
abstract::Aversive Pavlovian conditioning is an important tool used to investigate neurobiological mechanisms underlying the acquisition and expression of fear. Most studies have used nonprimate species employing electrical shock as the unconditioned stimulus (US). Although important advances have been made in understanding the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(96)00145-x
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:The development of body weight is determined by different factors, namely genetic, behavioral, parental and physiological. OBJECTIVE:To investigate whether genetic, behavioral, parental and physiological factors are involved and the extent of involvement in the development of body weight at ages 12 and 13 y...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.12.021
更新日期:2008-03-18 00:00:00
abstract:BACKGROUND:Negative affect is shown consistently to promote unhealthy food choices and dietary intake in laboratory studies. However, this relationship in naturalistic settings is less clear and previous research is limited by dietary assessment methodology and neglects to account for several important moderating varia...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2019.05.011
更新日期:2019-08-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90308-1
更新日期:1984-04-01 00:00:00
abstract::Many clinical studies show that a sizeable proportion of male alcoholics are also inclined to act violently and aggressively. Given this association in humans, we asked whether a relationship exists between ethanol intake and aggressive behaviour in laboratory rats. In a first test of the hypothesis, we measured ethan...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(95)02156-6
更新日期:1996-04-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.05.022
更新日期:2015-10-01 00:00:00
abstract::The effect of single and chronic methamphetamine (MAP) administration on ischemia-induced hyperactivity was investigated and the mechanism of ischemia-induced hyperactivity was discussed. Ischemia-induced hyperactivity was recognized 3 h after ischemia. However, ischemia-induced hyperactivity at 1 day after ischemia w...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(01)00549-2
更新日期:2001-09-01 00:00:00
abstract::It has been recognized for some time that a number of different neuropeptides exert powerful effects on food intake. During the last few years, the neurocircuitry within which these peptides operate has also begun to be elucidated. Peptidergic feeding-regulatory neurones are found both in the hypothalamus and the brai...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/s0031-9384(01)00611-4
更新日期:2001-11-01 00:00:00
abstract::Chemoreception of foodstuff in the gut is performed by endocrine cells dispersed in the gut epithelium. They are bipolar cells extending an apical process to the gut lumen and releasing their messenger substances from the cell base in response to the apical stimuli. The cells share cell-biological features with neuron...
journal_title:Physiology & behavior
pub_type: 杂志文章,评审
doi:10.1016/0031-9384(91)90198-w
更新日期:1991-05-01 00:00:00
abstract::The following study investigated the diurnal variation in body temperature of the young monkey infant and assessed the role that the mother plays in the development of the temperature rhythm. Using an implantable biotelemetry system, core body temperature and motoric activity were evaluated in maternally-reared and ha...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90082-d
更新日期:1992-05-01 00:00:00
abstract::We determined the serum levels of calcitonin (CT), calcium (Ca), and thyroxine (Ti) in lean (?/+) and fatty (fa/fa) male Zucker rats 10 weeks and 10-12 months of age. The most dramatic finding was a high level of serum CT (3.24 +/- 1.18 ng/ml) in young fatties whereas sera from young leans were all below the limit of ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(83)90099-9
更新日期:1983-07-01 00:00:00
abstract::NaCl detection thresholds were determined for 12.5- and 50-mm(2) lingual areas at four anterior tongue locations in eight subjects using a device that allowed for accurate temporal and spatial presentation of tastants to small regions of the anterior tongue. The locations, all on the right side of the tongue, were the...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(00)00416-9
更新日期:2001-02-01 00:00:00
abstract::Experiments were performed to study the role of angiotensin (Ang) AT1a receptors in dietary sodium-induced changes in blood pressure (BP). We measured light/dark rhythms in BP, heart rate (HR) and drinking behavior in Ang AT1a deficient (AT1a -/-) and wild type (AT1a +/+) mice with arterial telemetric catheters. Mice ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2006.03.008
更新日期:2006-06-15 00:00:00
abstract::Bilateral intracranial injections of puromycin (10 micrograms/0.5 microliter vehicle) into the preoptic area (POA) of steroid-primed ovariectomized rats resulted in a significant decrease in the lordosis response when compared to saline treated controls. To determine the extent of puromycin diffusion after intracrania...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(84)90162-8
更新日期:1984-09-01 00:00:00
abstract::Brief interruptions of REM sleep are considered to be part of the REM episode. The maximum allowable duration of such an interruption, which is used to define the end of the REM episode, is currently a matter of debate. Making measurements on individual REM cycles, inter-REM interval analysis was carried out to determ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(91)90576-a
更新日期:1991-12-01 00:00:00
abstract::A wide range of data in the literature suggests that environmental enrichment has beneficial effects on various cognitive parameters in rodents. However, the magnitude of these effects and their persistence after the cessation of enrichment vary markedly across studies, with the use of different enrichment protocols p...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2007.09.009
更新日期:2008-01-28 00:00:00
abstract::Chronic nutritional stress can have a negative impact on an individual's learning ability and memory. However, in social animals that share food among group members, such as the honey bee (Apis mellifera L.), it is unknown whether group-level nutritional stress is manifested in the learning performance of individuals....
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2008.08.003
更新日期:2008-12-15 00:00:00
abstract::The oxytocin (OT) neural system is thought to be involved in the underlying mechanisms that guide the development of social behaviors. In the present study, we examined the effects of neonatal oxytocin manipulation in mice. Within 24 hours after birth, pups in the treatment group randomly received an intraperitoneal i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2014.05.010
更新日期:2014-06-22 00:00:00
abstract::A ligation of the common bile duct (BDL) produces cholestasis and hypotension and increases the daily ingestion of sodium chloride solutions in rats. Low-dose captopril (CAP) treatment also modifies the ingestion of water and sodium in naive rats, and may do so in cholestatic rats. This study examined whether the elev...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(98)00295-9
更新日期:1999-05-01 00:00:00
abstract::Male sexual satiety has been associated with a decrease in dopamine levels. Spontaneous recovery of copulatory behavior begins at least 72 h after sexual satiety is reached or in the condition in which a sexually-satiated male is exposed to a new receptive female distinct from the one with which sexual satiety was rea...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2015.08.029
更新日期:2015-11-01 00:00:00
abstract::Lateral asymmetries in the direction of turning during escape behavior in a species of teleost fish, Jenynsia lineata, are reported. When faced with the visual image of a simulated predator, approximately half of the individuals exhibited a significant bias to turn rightwards or leftwards, and the asymmetry tended to ...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/s0031-9384(96)00308-3
更新日期:1997-01-01 00:00:00
abstract::This study investigated differences in the cortisol response of fish at different developmental stages after exposure to an acute stressor. Three experiments using 126 fish each were performed using 3 different age groups of jundiá (Rhamdia quelen): fingerlings at 60 days of age, juveniles at 180 days, and adults at 3...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2012.01.013
更新日期:2012-05-15 00:00:00
abstract::The specific immune system is a protective mechanism that detects infection and fights it by production of antibodies. Newborns are especially susceptible to infections because their immune system is not yet as fully developed as that of adults. This has been well established in altricial mammals. Fighting infection i...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2005.04.008
更新日期:2005-06-02 00:00:00
abstract::The effect of epileptogenic lesion of amygdala on spatial working memory was examined in rats after unilateral (U, n = 9) or bilateral (B, n = 8) injection of 1 or 0.5 mu of 0.2% kainate into the amygdaloid complex. Another group of unilaterally lesioned rats (T, n = 9) received 8 days after kainate injection grafts o...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(89)90124-8
更新日期:1989-02-01 00:00:00
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journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/j.physbeh.2017.03.028
更新日期:2017-06-01 00:00:00
abstract::Using rats of the inbred BN and WAG strain, we tested the hypothesis that chronic dietary choline supplementation would especially affect the timing behavior of BN rats because of their lower cholinergic activity and their poor performance in aversively motivated learning and memory tasks. An apparent effect of chroni...
journal_title:Physiology & behavior
pub_type: 杂志文章
doi:10.1016/0031-9384(92)90068-d
更新日期:1992-05-01 00:00:00