Neurophysiology in multiple sclerosis.

abstract：:Insomnia in its chronic form is present in high numbers of patients presenting to physicians. As older women who have medical problems have the highest rates of chronic insomnia, physicians must have a high index of suspicion and be prepared to explore various etiologic factors that might be operative. Treatment shoul...

journal_title：Neurologic clinics

authors： Becker PM

更新日期：2005-11-01 00:00:00

abstract：:The authors highlight the potential importance of neuropeptides as clinical tools in the study and treatment of pain. Although many questions remain unanswered, it is encouraging that several clinical and experimental advances have shed new light on the neuropharmacology of nociception and have prompted new hope for m...

journal_title：Neurologic clinics

authors： Recht LD,Abrams GM

更新日期：1986-11-01 00:00:00

abstract：:Postamputation phenomena, including painful and nonpainful phantom sensations occur following loss of limbs and other body parts. Peripheral and central nervous system mechanisms play a role in persistent phantom pain. Understanding the pathophysiology of this syndrome has improved in recent years. Comprehensive evalu...

journal_title：Neurologic clinics

authors： Weinstein SM

更新日期：1998-11-01 00:00:00

abstract：:Spontaneous ICH remains a formidable disease that continues to disable and kill the majority of its victims. Treatment of the disease continues to be controversial and without any proved success, such as improvement in the disease mortality or the resulting disability in survivors. Primary prevention is the most effec...

journal_title：Neurologic clinics

authors： Hsieh PC,Awad IA,Getch CC,Bendok BR,Rosenblatt SS,Batjer HH

更新日期：2006-11-01 00:00:00

abstract：:The immune system plays a significant role in Alzheimer disease (AD). β-Amyloid deposition in the cortex is thought to be an initiating event in AD and the widely believed amyloid hypothesis proposes removal of amyloid may delay disease progression. Human trials of active or passive immune agents have failed to show b...

journal_title：Neurologic clinics

authors： Farlow MR,Brosch JR

更新日期：2013-08-01 00:00:00

abstract：:Dementia, defined as progressive cognitive decline, is a feature of a wide variety of genetic disorders. For example, a search of "dementia" in the Online Mendelian Inheritance in Man (www.ncbi.nlm.nih.gov/Omim) reveals 162 entries. Therefore this article cannot be encyclopedic and will be necessarily restricted to mo...

journal_title：Neurologic clinics

authors： Hedera P,Turner RS

更新日期：2002-08-01 00:00:00

abstract：:Selecting appropriate laboratory tests in diagnosing peripheral neuropathies is important because it increases the yield of correct diagnoses and is cost effective. A large number of tests are available. This article provides a guide to selecting appropriate tests and reviews the clinical situations that suggest speci...

journal_title：Neurologic clinics

authors： Griffin JW,Hsieh ST,McArthur JC,Cornblath DR

更新日期：1996-02-01 00:00:00

abstract：:Classifications and definitions are essential to facilitate communication; promote accurate diagnostic criteria; develop, test, and use effective therapies; and specify knowledge gaps. This article describes the development of the International Classification of Vestibular Disorders (ICVD) initiative. It describes its...

journal_title：Neurologic clinics

authors： Bisdorff AR,Staab JP,Newman-Toker DE

更新日期：2015-08-01 00:00:00

abstract：:Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy. The optimal choice of treatment...

journal_title：Neurologic clinics

authors： Nguyen TD,DeAngelis LM

更新日期：2007-11-01 00:00:00

abstract：:There are a number of medications that effectively relieve symptoms in patients with functionally disabling tics. Neuroleptic drugs remain the most predictably effective tic-suppressing agents, but other approaches may be beneficial. This article reviews the spectrum of available therapies to suppress tics and provide...

journal_title：Neurologic clinics

authors： Kurlan R

更新日期：1997-05-01 00:00:00

abstract：:In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed. In a...

journal_title：Neurologic clinics

authors： Trask CL,Kosofsky BE

更新日期：2000-08-01 00:00:00

abstract：:Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determine appropriate eva...

journal_title：Neurologic clinics

authors： Garcia PA,Alldredge BK

更新日期：1994-02-01 00:00:00

abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...

journal_title：Neurologic clinics

authors： Kramer CL

更新日期：2017-11-01 00:00:00

abstract：:Focal, small-to-moderate and transient improvement occurred in the muscle strength and function of patients with ALS who received TRH in dose-response and screening studies. In a small pilot study of 12 patients, 3 months administration of TRH at 10 mg per kg on alternate days resulted in localized increased strength ...

journal_title：Neurologic clinics

authors： Brooks BR,Sufit RL,Montgomery GK,Beaulieu DA,Erickson LM

更新日期：1987-02-01 00:00:00

abstract：:Cervicogenic headache is pain referred to the head from a source in the cervical spine or mediated by cervical nerves. Clinical features allow for no more than a diagnosis of probable cervicogenic headache. Definitive diagnosis requires evidence of a cervical source of pain. For most treatments, the evidence is limite...

journal_title：Neurologic clinics

authors： Bogduk N

更新日期：2014-05-01 00:00:00

abstract：:This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory dam...

journal_title：Neurologic clinics

authors： Wu GF,Alvarez E

更新日期：2011-05-01 00:00:00

abstract：:Neurologic complications are a major cause of morbidity, complicating open heart surgery, cardiac catheterization, and interventional techniques. Global or focal brain ischemia related to embolism or hypoperfusion predominates. Breakthrough cerebral hemorrhage and infection can complicate cardiac transplantation. Iden...

journal_title：Neurologic clinics

authors： Furlan AJ,Sila CA,Chimowitz MI,Jones SC

更新日期：1992-02-01 00:00:00

abstract：:Diagnostic testing is of limited value among patients with migraine who present to an emergency department. Various nonopioid, disease-specific treatments are available for patients who present to an emergency department with migraine headache and associated features. Emergency physicians should recognize that the acu...

journal_title：Neurologic clinics

authors： Friedman BW

更新日期：2019-11-01 00:00:00

abstract：:A large body of medical and ethical opinion holds that it is justifiable to terminate medical treatment for permanently unconscious persons. But opponents of particular decisions to withhold or withdraw treatment may argue that the decisions violate laws against homicide, pose a threat to the lives of other less sever...

journal_title：Neurologic clinics

authors： Beresford HR

更新日期：1989-11-01 00:00:00

abstract：:The neurologic manifestations of gastrointestinal disease are generally thought to be uncommon, although an increasing number of previously unidentified associations are being established. These neurologic disorders may result from nutritional or non-nutritional causes. In the absence of clear malnutrition, it is like...

journal_title：Neurologic clinics

authors： Albers JW,Nostrant TT,Riggs JE

更新日期：1989-08-01 00:00:00

abstract：:Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as re...

journal_title：Neurologic clinics

authors： Newmark J

更新日期：2005-05-01 00:00:00

abstract：:Throughout pregnancy and the puerperium, a variety of hormonal and physiologic changes occur that are associated with pregnancy-specific neurologic conditions, which may also influence known preexisting medical conditions or bring previously unknown neurologic conditions to clinical attention. This article reviews the...

journal_title：Neurologic clinics

authors： Delfyett WT,Fetzer DT

更新日期：2012-08-01 00:00:00

abstract：:Mortality and morbidity from kidney disease and the spectrum of renal-associated neurologic disease have changed markedly since the introduction of renal dialysis and with the advent of renal transplantation. This article includes historical studies of the neurologic complications of acute uremia, now fairly uncommon,...

journal_title：Neurologic clinics

authors： Palmer CA

更新日期：2002-02-01 00:00:00

abstract：:Myopathies are a heterogeneous group of disorders that can be challenging to diagnose. This review provides a diagnostic approach based predominantly on the clinical history and neurologic examination. Laboratory testing that can be used to confirm the suspected diagnosis based on this pattern recognition approach is ...

journal_title：Neurologic clinics

authors： Barohn RJ,Dimachkie MM,Jackson CE

更新日期：2014-08-01 00:00:00

abstract：:The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to d...

journal_title：Neurologic clinics

authors： Pierce AL,Bullain SS,Kawas CH

更新日期：2017-05-01 00:00:00

abstract：:Conventional disease-modifying agents are only moderately effective, so breakthrough disease activity is commonly seen. The evidence from randomized clinical trials and real-world observational data supporting the use of the second-line agents natalizumab, mitoxantrone, and cyclophosphamide are reviewed. Potential fut...

journal_title：Neurologic clinics

authors： Marriott JJ,O'Connor PW

更新日期：2011-05-01 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) and causalgia appear to reflect identical pictures even though the latter is related to nerve injury and the former is not. Overriding past and present skepticism about a role for the sympathetic system in their cause and treatment, the International Association for the Study of Pain...

journal_title：Neurologic clinics

authors： Ochoa JL,Verdugo RJ

更新日期：1995-05-01 00:00:00

abstract：:Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...

journal_title：Neurologic clinics

authors： Cohen JE,Leker RR,Rabinstein A

更新日期：2013-08-01 00:00:00

abstract：:This article concentrates primarily on infections of viral origin, although numerous microorganisms can infect the fetal and newborn brain (see Tables 1 and 2). Intrauterine infections occur most often for HIV, CMV and rubella, whereas HSV is preferentially transmitted intrapartum. In the last decade, changes in the e...

journal_title：Neurologic clinics

authors： Griffith BP,Booss J

更新日期：1994-08-01 00:00:00

abstract：:The natural history of MS is highly variable. There is substantial heterogeneity in the clinical manifestations but, at this point, it is reasonable to consider all idiopathic inflammatory demyelinating diseases of the central nervous system as representing a spectrum of the same disease. In large populations, 20% to ...

journal_title：Neurologic clinics

authors： Weinshenker BG

更新日期：1995-02-01 00:00:00