Dissociation between c-fos gene expression and DNA synthesis in rat parotid glands.

Abstract:

:Two experimental approaches were used to examine the relationship between c-fos gene expression and tissue proliferative responses. Beta-Adrenergic and muscarinic receptor stimulation yielded equivalent levels of c-fos expression, although only beta-adrenergic receptor agonists are reported as capable of eliciting DNA synthesis in parotid cells. Similarly, beta-adrenergic stimuli evoked comparable levels of c-fos expression in parotid cells from 2- and 12-month-old rats, whereas DNA synthesis has been shown to be much greater in younger animals. The results indicate that enhanced c-fos expression by itself is incapable of eliciting proliferative responses in rat parotid glands.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Mirels L,Baum BJ,Kousvelari E

doi

10.1016/0003-9969(89)90088-5

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

511-5

issue

7

eissn

0003-9969

issn

1879-1506

pii

0003-9969(89)90088-5

journal_volume

34

pub_type

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