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High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors.

Abstract：

OBJECTIVES:to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. MATERIALS AND METHODS:Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. RESULTS:Promoter hypermethylation of the two genes was a very frequent event in both neoplasms - between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P=0.00), and significantly decreased in comparison to the carcinoma group (P=0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P=0.044 and P=0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P=0.013). CONCLUSION:Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and p14(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Nikolic N,Anicic B,Carkic J,Simonovic J,Toljic B,Tanic N,Tepavcevic Z,Vukadinovic M,Konstantinovic VS,Milasin J

doi

10.1016/j.archoralbio.2015.08.011

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1662-6

issue

11

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(15)30029-7

journal_volume

60

pub_type

杂志文章

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