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Developmental pathways activated in melanocytes and melanoma.

Abstract：

:Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells. Melanoma cells share many characteristics with melanocyte precursors, suggesting that melanoma cells utilize the developmental programs of their normal counterpart for their own progression. The pigmentation system provides an advantageous model to assess survival pathway interactions in the melanocytic lineage, as genetic alterations controlling melanocyte development can be easily detectable by coat color phenotype that do not affect the viability of an animal. By integrating combinatorial gene knockout approaches, cell-based assays and immunohistochemical observations, recent studies have illustrated several genes and pathways that play important roles both in melanocyte specification and maintenance and in melanoma formation and progression. We are reviewing those genes and pathways to understand the connection between normal and cancerous development and to reveal therapeutic potential of targeting developmental pathways for melanoma therapy.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Liu J,Fukunaga-Kalabis M,Li L,Herlyn M

doi

10.1016/j.abb.2014.07.023

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

13-21

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(14)00274-4

journal_volume

563

pub_type

杂志文章,评审

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