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Covalent binding of [14C]thiourea to protein in lungs from endotoxin-treated rats.

Abstract：

:Administration of thiourea to mature male rats at a dosage of 3.5 mg/kg (ip) produced marked pleural effusion by 2 hr (3-4 ml). Pretreatment with bacterial lipopolysaccharide (endotoxin) significantly reduced this pleural effusion (less than 0.5 ml). Despite this unequivocal effect, there was no corresponding reduction in the covalent binding of [14C]thiourea to lung protein. These data indicate that the protective effect of endotoxin against the initial stages of thiourea pneumotoxicity does not involve a reduction in binding of the [14C]thiourea or a metabolite to lung protein. However, alterations in low levels of binding to specific cell types or particular protein(s) relative to covalent binding cannot be ruled out.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Hollinger MA

doi

10.1016/0041-008x(83)90191-6

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

163-4

issue

1

eissn

0041-008X

issn

1096-0333

pii

0041-008X(83)90191-6

journal_volume

70

pub_type

杂志文章

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