Cryoprecipitate therapy.

Abstract:

:Cryoprecipitate, originally developed as a therapy for patients with antihaemophilic factor deficiency, or haemophilia A, has been in use for almost 50 yr. However, cryoprecipitate is no longer administered according to its original purpose, and is now most commonly used to replenish fibrinogen levels in patients with acquired coagulopathy, such as in clinical settings with haemorrhage including cardiac surgery, trauma, liver transplantation (LT), or obstetric haemorrhage. Cryoprecipitate is a pooled product that does not undergo pathogen inactivation, and its administration has been associated with a number of adverse events, particularly transmission of blood-borne pathogens and transfusion-related acute lung injury. As a result of these safety concerns, along with emerging availability of alternative fibrinogen preparations, cryoprecipitate has been withdrawn from use in a number of European countries. Compared with the plasma from which it is prepared, cryoprecipitate contains a high concentration of coagulation factor VIII, coagulation factor XIII, and fibrinogen. Cryoprecipitate is usually licensed by regulatory authorities for the treatment of hypofibrinogenaemia, and recommended for supplementation when plasma fibrinogen levels decrease below 1 g litre(-1); however, this threshold is empiric and is not based on solid clinical evidence. Consequently, there is uncertainty over the appropriate dosing and optimal administration of cryoprecipitate, with some guidelines from professional societies to guide clinical practice. Randomized, controlled trials are needed to determine the clinical efficacy of cryoprecipitate, compared with the efficacy of alternative preparations. These trials will allow the development of evidence-based guidelines in order to inform physicians and guide clinical practice.

journal_name

Br J Anaesth

authors

Nascimento B,Goodnough LT,Levy JH

doi

10.1093/bja/aeu158

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

922-34

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)30648-7

journal_volume

113

pub_type

杂志文章,评审
  • Environmental and economic impact of using increased fresh gas flow to reduce carbon dioxide absorbent consumption in the absence of inhalational anaesthetics.

    abstract:BACKGROUND:Increasing fresh gas flow (FGF) to a circle breathing system reduces carbon dioxide (CO2) absorbent consumption. We assessed the environmental and economic impacts of this trade-off between gas flow and absorbent consumption when no inhalational anaesthetic agent is used. METHODS:A test lung with fixed CO2 ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.07.043

    authors: Zhong G,Abbas A,Jones J,Kong S,McCulloch T

    更新日期:2020-11-01 00:00:00

  • Gastric and lower oesophageal sphincter (LOS) pressures in early pregnancy.

    abstract::Gastric (GP) and lower oesophageal sphincter pressures (LOSP) were measured in non-pregnant female volunteers (group I) and pregnant women with (group III) or without (group II) heartburn. Patients in early pregnancy had greater gastric pressures than group I. Mean barrier pressure (LOSP-GP) was significantly decrease...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.4.381

    authors: Brock-Utne JG,Dow TG,Dimopoulos GE,Welman S,Downing JW,Moshal MG

    更新日期:1981-04-01 00:00:00

  • A sheep preparation for studying interactions between blood flow and drug disposition. IV: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition.

    abstract::Control measurements of blood flow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steady-state conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to ap...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.12.1239

    authors: Runciman WB,Mather LE,Ilsley AH,Carapetis RJ,Upton RN

    更新日期:1985-12-01 00:00:00

  • Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation.

    abstract:BACKGROUND:Anaesthetics blunt neuronal responses to noxious stimulation, including effects on electroencephalographic (EEG) responses. It is unclear how anaesthetics differ in their ability to modulate noxious stimulation-evoked EEG activation. We investigated the actions of propofol and halothane on EEG responses to n...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei208

    authors: Orth M,Barter L,Dominguez C,Atherley R,Carstens E,Antognini JF

    更新日期:2005-10-01 00:00:00

  • Inhalation induction with sevoflurane: a double-blind comparison with propofol.

    abstract::We conducted a randomized, double-blind comparison of 8% sevoflurane and propofol as induction agents for day-case cystoscopy in 102 patients. All patients received an i.v. cannula and breathed oxygen 5 litre min-1. Anaesthesia was induced with propofol i.v. or inhalation of 8% sevoflurane and 10% Intralipid (as a pla...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/78.4.356

    authors: Thwaites A,Edmends S,Smith I

    更新日期:1997-04-01 00:00:00

  • Extradural analgesia with clonidine and fentanyl compared with 0.25% bupivacaine in the first stage of labour.

    abstract::Conventional extradural analgesia during labour with 0.25-0.375% bupivacaine may induce motor weakness and subjective sensory deficit, reducing maternal satisfaction. Even in a regimen for ambulatory extradural analgesia (0.1% bupivacaine-fentanyl 2 micrograms ml-1), a potential for proprioreception impairment exists,...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/76.2.319

    authors: Buggy DJ,MacDowell C

    更新日期:1996-02-01 00:00:00

  • IV clonidine for post-extradural shivering in parturients: a preliminary study.

    abstract::We have studied the efficacy of i.v. clonidine to suppress post-extradural shivering in parturients. Forty healthy parturients who received extradural block for labour (n = 20) or for Caesarean section (n = 20) and who required treatment for shivering after delivery were allocated randomly to two groups. Group I recei...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/71.2.294

    authors: Capogna G,Celleno D

    更新日期:1993-08-01 00:00:00

  • Infusion model for fentanyl based on pharmacokinetic analysis.

    abstract::The calculation of pharmacokinetic parameters after a bolus injection of fentanyl allowed an i.v. infusion scheme which guarantees analgesia for the entire duration of surgery, with the advantage of steady plasma concentration and body content. In the initial phase after bolus injection, the serum concentration decrea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.10.1021

    authors: Hengstmann JH,Stoeckel H,Schüttler J

    更新日期:1980-10-01 00:00:00

  • Leukemia inhibitory factor (LIF) potentiates antinociception activity and inhibits tolerance induction of opioids.

    abstract:BACKGROUND:The efficacy of opioids typically decreases after long-term use owing to the development of tolerance. Glial activation and the upregulation of proinflammatory cytokines are related to the induction of tolerance. We investigated the effect of leukemia inhibitory factor (LIF) on morphine analgesia and toleran...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aew247

    authors: Tu HJ,Kang KH,Ho SY,Liou HC,Liou HH,Lin CP,Fu WM

    更新日期:2016-10-01 00:00:00

  • Comparative evaluation of the cerebral state index and the bispectral index during target-controlled infusion of propofol.

    abstract:BACKGROUND:Cerebral state index (CSI) has recently been introduced as an intra-operative monitor of anaesthetic depth. We compared the performance of the CSI to the bispectral index (BIS) in measuring depth of anaesthesia during target-controlled infusion (TCI) of propofol. METHODS:Twenty Chinese patients undergoing g...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei253

    authors: Zhong T,Guo QL,Pang YD,Peng LF,Li CL

    更新日期:2005-12-01 00:00:00

  • Comparison of two ultrasound guided approaches for axillary vein catheterization: a randomized controlled non-inferiority trial.

    abstract:BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev458

    authors: Buzançais G,Roger C,Bastide S,Jeannes P,Lefrant JY,Muller L

    更新日期:2016-02-01 00:00:00

  • Nausea and vomiting after gynaecological surgery: a meta-analysis of factors affecting their incidence.

    abstract::A total of 1442 patients who had major gynaecological surgery were recruited into three multicentre studies using a standard general anaesthetic technique in order to assess the efficacy of various doses of orally administered ondansetron in the prevention of postoperative nausea and vomiting. A total of 1257 patients...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,meta分析,多中心研究,随机对照试验

    doi:10.1093/bja/71.4.517

    authors: Haigh CG,Kaplan LA,Durham JM,Dupeyron JP,Harmer M,Kenny GN

    更新日期:1993-10-01 00:00:00

  • Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury.

    abstract:BACKGROUND:Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketamine have ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeg028

    authors: Hijazi Y,Bodonian C,Bolon M,Salord F,Boulieu R

    更新日期:2003-02-01 00:00:00

  • Maternal haemorrhage.

    abstract::Maternal haemorrhage is the leading cause of preventable maternal death worldwide and encompasses antepartum, intrapartum, and postpartum bleeding. This review highlights factors that predispose to severe bleeding, its management, and the most recent treatment and guidelines. Advances in obstetric care have provided p...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aep303

    authors: Walfish M,Neuman A,Wlody D

    更新日期:2009-12-01 00:00:00

  • The evolution of robotic surgery: surgical and anaesthetic aspects.

    abstract::Robotic surgery pushes the frontiers of innovation in healthcare technology towards improved clinical outcomes. We discuss the evolution to five generations of robotic surgical platforms including stereotactic, endoscopic, bioinspired, microbots on the millimetre scale, and the future development of autonomous systems...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aex383

    authors: Ashrafian H,Clancy O,Grover V,Darzi A

    更新日期:2017-12-01 00:00:00

  • Evaluation of an intervention to reduce tidal volumes in ventilated ICU patients.

    abstract:BACKGROUND:There is considerable evidence that the use of tidal volumes <6 ml kg(-1) predicted body weight (PBW) reduces mortality in mechanically ventilated patients. We evaluated the effectiveness of using a large screen displaying delivered tidal volume in ml kg(-1) (PBW) for reducing tidal volumes. METHODS:We asse...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aev110

    authors: Bourdeaux CP,Birnie K,Trickey A,Thomas MJ,Sterne J,Donovan JL,Benger J,Brandling J,Gould TH

    更新日期:2015-08-01 00:00:00

  • N-terminal prohormone of brain natriuretic peptide: a useful tool for the detection of acute pulmonary artery embolism in post-surgical patients.

    abstract:BACKGROUND:Acute pulmonary embolism (APE) is an important clinical problem in patients after major surgery and often remains a difficult diagnosis because of unspecific clinical symptoms. Therefore, we investigated the role of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) for the detection of APE. MET...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aes315

    authors: Winkler BE,Schuetz W,Froeba G,Muth CM

    更新日期:2012-12-01 00:00:00

  • Expressiveness of global coagulation parameters in dilutional coagulopathy.

    abstract:BACKGROUND:Plasma-free volume replacement in haemorrhage often results in dilutional coagulopathy. Prothrombin time index (PTI) and activated partial thromboplastin time (aPTT) are used for monitoring haemostasis but have not yet been clinically evaluated. Our aim was to investigate the effects of haemodilution on the ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq199

    authors: Weiss G,Lison S,Spannagl M,Heindl B

    更新日期:2010-10-01 00:00:00

  • Association of opioid prescribing practices with chronic pain and benzodiazepine co-prescription: a primary care data linkage study.

    abstract:BACKGROUND:Opioid prescribing is increasing worldwide with associated increases in misuse and other harms. We studied variations in national opioid prescription rates, indicators of prescribing quality, co-prescribing of benzodiazepines and relationship with pain severity in Scotland. METHODS:Electronic linkages of op...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.02.022

    authors: Torrance N,Mansoor R,Wang H,Gilbert S,Macfarlane GJ,Serpell M,Baldacchino A,Hales TG,Donnan P,Wyper G,Smith BH,Colvin L

    更新日期:2018-06-01 00:00:00

  • Epidural analgesia in a child with sickle cell disease complicated by acute abdominal pain and priapism.

    abstract::We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/87.6.935

    authors: Labat F,Dubousset AM,Baujard C,Wasier AP,Benhamou D,Cucchiaro G

    更新日期:2001-12-01 00:00:00

  • Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.

    abstract:BACKGROUND:We used an automated bispectral index (BIS)-guided dual-loop controller to determine propofol and remifentanil requirements during general anaesthesia in obese and lean surgical patients. METHODS:Obese patients, BMI>35 kg m(-2), and lean patients (<25 kg m(-2)) having laparoscopic procedures were prospectiv...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/bja/aeu401

    authors: Liu N,Lory C,Assenzo V,Cocard V,Chazot T,Le Guen M,Sessler DI,Journois D,Fischler M

    更新日期:2015-04-01 00:00:00

  • Intradermal compared with prick testing in the diagnosis of anaesthetic allergy.

    abstract::We have tested the hypothesis that intradermal testing is a more effective method for determining the drug responsible for anaesthetic anaphylactic reactions than prick testing in 212 consecutive patients, aged more than 10 yr, referred to an anaesthetic allergy clinic over a 4-yr period. The study was a prospective, ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/79.1.59

    authors: Fisher MM,Bowey CJ

    更新日期:1997-07-01 00:00:00

  • Association of intraoperative anaesthesia handovers with patient morbidity and mortality: a systematic review and meta-analysis.

    abstract:BACKGROUND:Handover of anaesthesia patient care during surgery is common; however, its association with patient outcome is unclear. This systematic review aimed to assess the impact of anaesthesia handover during surgery on patient outcome. METHODS:All prospective and retrospective clinical studies specifically invest...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.bja.2020.05.062

    authors: Boet S,Djokhdem H,Leir SA,Théberge I,Mansour F,Etherington N

    更新日期:2020-10-01 00:00:00

  • Comparison of hyperbaric and plain articaine in spinal anaesthesia for open inguinal hernia repair.

    abstract:BACKGROUND:Fast onset and short duration are prominent properties of the amide-type local anaesthetic articaine. Similar to bupivacaine, a hyperbaric solution of articaine may produce faster onset and shorter duration of spinal anaesthesia than a plain solution. METHODS:Patients undergoing open inguinal hernia repair ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aen294

    authors: Bachmann M,Pere P,Kairaluoma P,Rosenberg PH,Kallio H

    更新日期:2008-12-01 00:00:00

  • Prospective study of device-related complications in intensive care unit detected by virtual autopsy.

    abstract:BACKGROUND:There has been increasing use of invasive techniques, such as extracorporeal organ support, in intensive care units (ICU), and declining autopsy rates. Thus, new measures are needed to maintain high-quality standards. We investigated the potential of computed tomography (CT)-based virtual autopsy to substitu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.02.031

    authors: Wichmann D,Heinemann A,Zähler S,Vogel H,Höpker W,Püschel K,Kluge S

    更新日期:2018-06-01 00:00:00

  • Collaborative study of the frequency of the fluoride-resistant cholinesterase variant in patients with malignant hyperpyrexia.

    abstract::Cholinesterase phenotyping studies have been carried out in two laboratories on blood specimens from 28 patients shown to be susceptible to malignant hyperpyrexia. In contrast to previously published reports, no evidence could be found for an increase in the frequency of the E1u E1f genotype above that known to occur ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.3.245

    authors: Evans RT,Iqbal J,Ellis FR,Halsall PJ,Dietz AA,Lubrano T,Rubinstein HM

    更新日期:1981-03-01 00:00:00

  • Anaphylactic reaction after methylene blue-treated plasma transfusion.

    abstract::Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate al...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer009

    authors: Dewachter P,Castro S,Nicaise-Roland P,Chollet-Martin S,Le Beller C,Lillo-le-Louet A,Mouton-Faivre C

    更新日期:2011-05-01 00:00:00

  • Therapeutic potential of cannabis in pain medicine.

    abstract::Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance. Cannabinoids (CBs) are chemical compounds derived from cannabis. The major psychotropic CB delta-9-tetrahydrocannabino...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aen119

    authors: Hosking RD,Zajicek JP

    更新日期:2008-07-01 00:00:00

  • Buprenorphine induces ceiling in respiratory depression but not in analgesia.

    abstract:BACKGROUND:We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or appare...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael051

    authors: Dahan A,Yassen A,Romberg R,Sarton E,Teppema L,Olofsen E,Danhof M

    更新日期:2006-05-01 00:00:00

  • Use of di-isopropyl phenol as main agent for short procedures.

    abstract::The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with a...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/53.11.1197

    authors: Briggs LP,Clarke RS,Dundee JW,Moore J,Bahar M,Wright PJ

    更新日期:1981-11-01 00:00:00