Lipoprotein abnormalities in the pathogenesis of cerebral infarction and transient ischemic attack.

abstract：BACKGROUND AND PURPOSE:Large pulse pressure associates with atherosclerosis, but it is unclear if it contributes to the development of atherosclerosis or if atherosclerosis leads to pulse pressure widening. We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness ...

journal_title：Stroke

authors： Raitakari OT,Juonala M,Taittonen L,Jula A,Laitinen T,Kähönen M,Viikari JS

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although left atrial enlargement (LAE) increases incident stroke risk, the association with recurrent stroke is less clear. Our aim was to determine the association of LAE with recurrent stroke most likely related to embolism (cryptogenic and cardioembolic) and all ischemic stroke recurrences. M...

journal_title：Stroke

authors： Yaghi S,Moon YP,Mora-McLaughlin C,Willey JZ,Cheung K,Di Tullio MR,Homma S,Kamel H,Sacco RL,Elkind MS

更新日期：2015-06-01 00:00:00

abstract：UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...

journal_title：Stroke

authors： Gisvold SE,Safar P,Rao G,Moossy J,Kelsey S,Alexander H

更新日期：1984-09-01 00:00:00

abstract：:We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...

journal_title：Stroke

authors： Bromont C,Marie C,Bralet J

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels. Glutamate neurotoxicity may contribute to cerebral ischemic damage after recovery from cardiac arrest. Thus, LTG may prevent the bra...

journal_title：Stroke

authors： Crumrine RC,Bergstrand K,Cooper AT,Faison WL,Cooper BR

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The applicability of a novel differentiation technique in embolus detection based on the coincidence principle and using a multigate probe was evaluated in this study. METHODS:According to the coincidence method, high-intensity transients should only be classified as microembolic signals if they...

journal_title：Stroke

authors： Georgiadis D,Goeke J,Hill M,König M,Nabavi DG,Stögbauer F,Zunker P,Ringelstein EB

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Whether and how the arterial pathology underlying lacunar ischemic stroke differs from the atherothrombotic processes causing most other ischemic strokes is still debated. Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar art...

journal_title：Stroke

authors： Jackson CA,Hutchison A,Dennis MS,Wardlaw JM,Lewis SC,Sudlow CL

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies have suggested that the early excess risk of stroke in coronary artery bypass grafting (CABG) may be compensated for by a slow but progressive catch-up phenomenon in patients undergoing percutaneous coronary intervention (PCI). We therefore undertook this analysis to compare the temporal ...

journal_title：Stroke

authors： Athappan G,Chacko P,Patvardhan E,Gajulapalli RD,Tuzcu EM,Kapadia SR

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypoxic-ischemic (HI) brain injury in newborn infants represents a major cause of cerebral palsy, development delay, and epilepsy. Stem cell-based therapy has the potential to rescue and replace the ischemic tissue caused by HI and to restore function. However, the mechanisms by which stem cell t...

journal_title：Stroke

authors： Daadi MM,Davis AS,Arac A,Li Z,Maag AL,Bhatnagar R,Jiang K,Sun G,Wu JC,Steinberg GK

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coffee and tea consumption could potentially reduce the risk of stroke because these beverages have antioxidant properties, and coffee may improve insulin sensitivity. We examined the associations of coffee and tea consumption with risk of stroke subtypes. METHODS:We used prospective data from t...

journal_title：Stroke

authors： Larsson SC,Männistö S,Virtanen MJ,Kontto J,Albanes D,Virtamo J

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transorbital sonography may help establish diagnosis of central retinal artery occlusion (CRAO). Next to Doppler sonographic proof of CRAO, an intra-arterial spot sign can be detected in some cases. We hypothesized that it reflects calcified components. It may be associated with embolization from...

journal_title：Stroke

authors： Nedelmann M,Graef M,Weinand F,Wassill KH,Kaps M,Lorenz B,Tanislav C

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It was found that glutamate, a major neurotransmitter, is vasoactive in the cerebral circulation. However, the mechanism is unclear. This study was designed to investigate the role of nitric oxide (NO) and N-methyl-D-aspartate (NMDA) receptors in cerebral arteriolar dilation to glutamate. METHOD...

journal_title：Stroke

authors： Meng W,Tobin JR,Busija DW

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Coated-platelets, a subset of procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, support a robust prothrombinase activity and provide a unique measure of platelet thrombotic potential. Coated-platelet levels are increased in large artery stroke, and higher lev...

journal_title：Stroke

authors： Kirkpatrick AC,Tafur AJ,Vincent AS,Dale GL,Prodan CI

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Embolic complications during ultrasound examinations are a rare cause of neurological deficits. The present case documents the occurrence of embolism by a nonobstructive compression maneuver during transcranial Doppler examination, resulting in a minor stroke. CASE DESCRIPTION:A 63-year-old man ...

journal_title：Stroke

authors： Khaffaf N,Karnik R,Winkler WB,Valentin A,Slany J

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We know that significant cardiac involvement can occur in patients with acute intracranial hemorrhage, particularly in those with subarachnoid hemorrhage. These patients may present with electrocardiographic abnormalities that were previously thought to be benign. However, many die of cardiovascu...

journal_title：Stroke

authors： Elrifai AM,Bailes JE,Shih SR,Dianzumba S,Brillman J

更新日期：1996-04-01 00:00:00

abstract：:Cerebral venous blood gas tensions were correlated with elevated intracranial pressure in spontaneously breathing dogs lightly anesthetized with nitrous oxide/halothane. Intracranial pressure was elevated by infusion of artificial cerebrospinal fluid into a lateral ventricle. Respiration and blood pressure were monito...

journal_title：Stroke

authors： Grady PA,Blaumanis OR

更新日期：1986-09-01 00:00:00

abstract：:U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...

journal_title：Stroke

authors： Hall ED,Pazara KE,Braughler JM,Linseman KL,Jacobsen EJ

更新日期：1990-11-01 00:00:00

abstract：:We examined the 21-aminosteroid U74006F, a potent inhibitor of lipid peroxidation, for potential neuroprotective effects in a canine model of complete cerebral ischemia. Two 1.5-mg/kg boluses were administered to six dogs, the first bolus 15 minutes prior to a 12-minute episode of complete cerebral ischemia and the se...

journal_title：Stroke

authors： Perkins WJ,Milde LN,Milde JH,Michenfelder JD

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Astrocytes are potent regulators of brain capillary endothelial cell function. Recently, astrocytes were shown to regulate brain capillary endothelial expression of the fibrinolytic enzyme tissue plasminogen activator (tPA) and the anticoagulant thrombomodulin (TM). To study the mechanism of this...

journal_title：Stroke

authors： Tran ND,Correale J,Schreiber SS,Fisher M

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Physiologically, it appears plausible for physical activity to decrease stroke risk; however, epidemiological studies have produced mixed findings. Furthermore, few studies have examined specific kinds and intensities of activities. The purpose of this study was to examine the association between...

journal_title：Stroke

authors： Lee IM,Paffenbarger RS Jr

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:This prospective study was aimed to evaluate the effects of surgical revascularization on cerebral oxygen metabolism in moyamoya disease. METHODS:This study included totally 69 hemispheres of 42 patients who underwent superficial temporal artery to middle cerebral artery anastomosis and indirect...

journal_title：Stroke

authors： Kuroda S,Kashiwazaki D,Hirata K,Shiga T,Houkin K,Tamaki N

更新日期：2014-09-01 00:00:00

abstract：:We report the case of a young man with recurrent posterior circulation strokes over the course of 6 years. Standard stroke evaluation was unremarkable until careful review of catheter angiogram and CT angiogram images revealed a bony protuberance from the occiput impinging on the left vertebral artery. Local vessel in...

journal_title：Stroke

authors： Cronin CA,Aldrich EF,Kittner SJ

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after a subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared to standard clinical care, reduces the rate of DCI after subarachnoid hemorrha...

journal_title：Stroke

authors： Anetsberger A,Gempt J,Blobner M,Ringel F,Bogdanski R,Heim M,Schneider G,Meyer B,Schmid S,Ryang YM,Wostrack M,Schneider J,Martin J,Ehrhardt M,Jungwirth B

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population. METHODS:Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery...

journal_title：Stroke

authors： Ronkainen A,Niskanen M,Piironen R,Hernesniemi J

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...

journal_title：Stroke

authors： Michaelsen SM,Levin MF

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In acute basilar artery occlusion, intra-arterial thrombolysis or endovascular mechanical recanalization may result in higher recanalization rates than intravenous thrombolysis. However, many patients are admitted to community hospitals, where endovascular therapy is usually not readily available...

journal_title：Stroke

authors： Pfefferkorn T,Holtmannspötter M,Schmidt C,Bender A,Pfister HW,Straube A,Mayer TE,Brückmann H,Dichgans M,Fesl G

更新日期：2010-04-01 00:00:00

abstract：:Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. ...

journal_title：Stroke

authors： Jiang Y,Liu N,Wang Q,Yu Z,Lin L,Yuan J,Guo S,Ahn BJ,Wang XJ,Li X,Lo EH,Sun X,Wang X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Validation of the Boston criteria for the in vivo diagnosis of cerebral amyloid angiopathy (CAA) is challenging, because noninvasive diagnostic tests do not exist. Hereditary cerebral hemorrhage with amyloidosis-Dutch type is an accepted monogenetic model of CAA and diagnosis can be made with cer...

journal_title：Stroke

authors： van Rooden S,van der Grond J,van den Boom R,Haan J,Linn J,Greenberg SM,van Buchem MA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. METHODS:Male Wistar rats were subjected to embolic middle cerebral artery occlusion. Sildenafil (Viagra) was administered orally for 7 consecutive da...

journal_title：Stroke

authors： Zhang R,Wang Y,Zhang L,Zhang Z,Tsang W,Lu M,Zhang L,Chopp M

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The rate of nitric oxide (NO) generation from nitrite is linearly dependent on reductions in oxygen and pH levels. Recently, nitrite-derived NO has been reported to exert a profound protection against liver and heart ischemia-reperfusion injury. In this study, we hypothesized that nitrite would b...

journal_title：Stroke

authors： Jung KH,Chu K,Ko SY,Lee ST,Sinn DI,Park DK,Kim JM,Song EC,Kim M,Roh JK

更新日期：2006-11-01 00:00:00