Abstract:
BACKGROUND AND PURPOSE:We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. METHODS:Male Wistar rats were subjected to embolic middle cerebral artery occlusion. Sildenafil (Viagra) was administered orally for 7 consecutive days starting 2 or 24 hours after stroke onset at doses of 2 or 5 mg/kg per day. Ischemic rats administered the same volume of tap water were used as a control group. Functional outcome tests (foot-fault, adhesive removal) were performed. Rats were killed 28 days after stroke for analysis of infarct volume and newly generated cells within the subventricular zone and the dentate gyrus. Brain cGMP levels, expression of PDE5, and localized cerebral blood flow were measured in additional rats. RESULTS:Treatment with sildenafil significantly (P<0.05) enhanced neurological recovery in all tests performed. There was no significant difference of infarct volume among the experimental groups. Treatment with sildenafil significantly (P<0.05) increased numbers of bromodeoxyuridine-immunoreactive cells in the subventricular zone and the dentate gyrus and numbers of immature neurons, as indicated by betaIII-tubulin (TuJ1) immunoreactivity in the ipsilateral subventricular zone and striatum. The cortical levels of cGMP significantly increased after administration of sildenafil, and PDE5 mRNA was present in both nonischemic and ischemic brain. CONCLUSIONS:Sildenafil increases brain levels of cGMP, evokes neurogenesis, and reduces neurological deficits when given to rats 2 or 24 hours after stroke. These data suggest that this drug that is presently in the clinic for sexual dysfunction may have a role in promoting recovery from stroke.
journal_name
Strokejournal_title
Strokeauthors
Zhang R,Wang Y,Zhang L,Zhang Z,Tsang W,Lu M,Zhang L,Chopp Mdoi
10.1161/01.str.0000034399.95249.59subject
Has Abstractpub_date
2002-11-01 00:00:00pages
2675-80issue
11eissn
0039-2499issn
1524-4628journal_volume
33pub_type
杂志文章相关文献
STROKE文献大全abstract::Background and Purpose- To test the hypothesis that covert brain infarcts (CBIs) are more likely to be located in noneloquent brain areas compared with clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events compared with people without CBI. Methods- We used brain magnetic reson...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.026068
更新日期:2020-01-01 00:00:00
abstract::Among 21 patients with angiographically demonstrated stenosis of the middle cerebral artery (MCA) 14 presented with a stroke and 7 with transient ischaemic attacks (TIAs). Of the former 4 had further strokes (3 fatal); of the latter one had a fatal stroke. Only 2 of the 21 patients had TIAs during the follow-up period...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.2.237
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Short-term elevations in fine particulate matter air pollution (PM2.5) are associated with increased risk of acute cerebrovascular events. Evidence from the peripheral circulation suggests that vascular dysfunction may be a central mechanism. However, the effects of PM2.5 on cerebrovascular funct...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.000395
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. METHODS:We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk sco...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.553545
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Familial aggregation of intracranial aneurysms (IAs) indicates a genetic role in the pathogenesis of this disease. Despite a number of reported susceptibility loci, no disease-causing gene variants have been identified. In this study, we used a parametric genomewide linkage approach to search for...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.534396
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The objectives of the present study were to: (1) noninvasively identify white matter reorganization and monitor its progress within 6 weeks after the onset of stroke; and (2) quantitatively investigate the effect of recombinant human erythropoietin treatment on this structural change using in viv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.527713
更新日期:2009-03-01 00:00:00
abstract::Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment mod...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.118.023769
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reduction of cerebral blood flow and vasomotor reactivity (VMR) are thought to play an important role in the pathogenesis of cerebral microangiopathy. The aim of our study was to determine whether near-infrared spectroscopy (NIRS) can detect a reduced VMR in patients with microangiopathy, whether...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.4.924
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002957
更新日期:2013-12-01 00:00:00
abstract::The levels of lipid peroxides, determined as thiobarbituric acid reactive substances (TBARS), and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were examined in the blood from stroke-prone spontaneously hypertensive rats (SHRSP), with and without cerebral lesions, and normotensive W...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.10.3.323
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To clarify diagnostic entities in ischemic stroke we analyzed the relation between the severity of carotid atherosclerosis, coagulation parameters, lipoproteins, neurological status, and risk factors in 232 patients. METHODS:Duplex ultrasonography, computed tomography scan, and laboratory invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1811
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Declining trends in the incidence and mortality of stroke have been observed in Finland since the beginning of the 1980s until 1997. In this study we analyzed the trends in fatal and nonfatal strokes in Finland during 1991-2002. METHODS:The Finnish Hospital Discharge Register was linked to the N...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000152945.28543.4a
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS:We examined primary outcomes by National Institutes of Heal...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.001126
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke symptoms can be very stressful for family caregivers, but most knowledge about the prevalence and stressfulness of stroke-related patient problems is derived from convenience samples. In addition, little is known about perceived benefits of the stroke caregiving experience. The purpose of ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.545269
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:This systematic review summarizes the effectiveness of mirror therapy for improving motor function, activities of daily living, pain, and visuospatial neglect in patients after stroke. METHODS:We searched the Cochrane Stroke Group’s Trials Register (June 2011), the Cochrane Central Register of Controlled Tr...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/strokeaha.112.673087
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Stroke patients are heterogeneous not only with respect to etiology but also in terms of preexisting clinical conditions. Approximately one fifth of patients with acute stroke are hyperglycemic and/or have had a recent infectious or inflammatory condition. Summary of Review-- Experimental research indicates ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/hs1001.096588
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Arteriopathy is common in childhood arterial ischemic stroke (AIS) and predicts stroke recurrence. Currently available vascular imaging techniques mainly image the arterial lumen rather than the vessel wall and have a limited ability to differentiate among common arteriopathies. We aimed to inves...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019827
更新日期:2018-04-01 00:00:00
abstract::In children with Moyamoya disease, transient ischemic attacks often occur during hyperventilation, and the frequency of attacks usually decreases with advancing age. To elucidate the mechanism of the attacks, the regional cerebral blood flow was measured during rest and/or hyperventilation in children aged 3-16 with M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.5.906
更新日期:1987-09-01 00:00:00
abstract::Background and Purpose- The importance of weight change for the risk of stroke is not well known. We examined the associations between early- and mid-life weight change and risks of stroke and death during long-term follow-up of healthy men. Methods- We recruited healthy men aged between 40 and 59 years and performed ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027233
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous studies exploring stroke-related caregiving focused solely on informal caregiving and a relatively limited set of activities. We sought to determine whether, and at what cost, stroke survivors receive more care than matched controls using an expanded definition of caregiving and inclusio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.012704
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The migratory efficiency of mesenchymal stem cells (MSC) toward cerebral infarct after transplantation is limited. Valproate (VPA) and lithium enhance in vitro migration of MSC by upregulating CXC chemokine receptor 4 and matrix metalloproteinase-9, respectively. Ability of VPA and lithium to pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.612788
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Combined effects of socioeconomic position and well-established risk factors on stroke incidence have not been formally investigated. METHODS:In a pooled cohort study of 68 643 men and women aged 30 to 70 years in Denmark, we examined the combined effect and interaction between socioeconomic pos...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.005252
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. Alpha1-antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000085085.20390.A3
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated. METHODS:The Cerebral Aneurysm Rerupture After Treatment (CARAT) study is an ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.107.495747
更新日期:2008-01-01 00:00:00
abstract::Cerebral ischemic events associated with arteriography are usually attributed to catheter-induced emboli. We present three patients with cerebral ischemia occurring 6 to 48 hours post-arteriography. We suspected that alternate pathogenic mechanisms were in effect. To evaluate the possibility that sustained platelet ac...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.16.3.431
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Clomethiazole is a neuroprotective drug that enhances gamma-aminobutyrate type A (GABA(A)) receptor activity. Its efficacy and safety were tested in the CLomethiazole Acute Stroke Study (CLASS). The protocol allowed a CT scan to be done after randomization but within 7 days of stroke onset to min...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.31.1.82
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Coronary artery bypass grafting (CABG) is a frequently performed surgical procedure that can be associated with neurological complications. Some studies have demonstrated that new focal brain lesions, detected by MRI, can develop after CABG. Furthermore, it has been suggested that the presence of...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000040408.75704.15
更新日期:2002-12-01 00:00:00
abstract::Background and Purpose- The ESCAPE trial (The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times) was a multicentre, randomized controlled trial of endovascular thrombectomy versus standard care for patients with acute ischemic strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.024096
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigated the effect of hypothermia induced 1 hour after transient (2-hour) middle cerebral artery occlusion on the extent of ischemic cell damage in the rat. METHODS:Middle cerebral artery occlusion was induced extracranially by insertion of a nylon filament into the right internal caroti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.8.1235
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002567
更新日期:2013-12-01 00:00:00