Toxic megacolon in ulcerative colitis: a continuing challenge.

Abstract:

:The incidence, predisposing factors, management and outcome of toxic megacolon (TM) has been reviewed in 65 cases of severe ulcerative colitis (UC) and compared in 2 successive 6-year periods before and after January, 1973. Nineteen episodes of TM occurred in 18 patients. Despite a conscious aim towards earlier surgery in recent years this was not achieved, and despite more intensive medical therapy the incidence of TM was unchanged. Emergency operative mortality in UC fell from 36% to 21% but the mortality of TM remained at 30%. The chief cause of death was colonic perforation. Mortality was associated with increased age, longer pre-operative hospital stay and lower levels of serum albumin. These findings reemphasize the need for earlier surgery if TM is to be prevented, but such a policy must result in some unnecessary emergency colectomies.

journal_name

Postgrad Med J

authors

Muscroft TJ,Warren PM,Asquith P,Montgomery RD,Sokhi GS

doi

10.1136/pgmj.57.666.223

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

223-7

issue

666

eissn

0032-5473

issn

1469-0756

journal_volume

57

pub_type

杂志文章
  • Glomerulonephritis in sarcoidosis: causal relationship unproven.

    abstract::Two patients with sarcoidosis and glomerular mesangial proliferative lesions are described. Although a causative relationship between sarcoidosis and glomerulonephritis has been suggested, critical review of the literature fails to confirm this. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.797.206

    authors: Howard RS,Gabriel R

    更新日期:1992-03-01 00:00:00

  • Some cardiovascular problems with disopyramide.

    abstract::Five patients with apparent adverse cardiovascular effects of disopyramide are reveiwed. Attention is drawn to the following problems. (1) A vagolytic effect may produce a sinus tachycardia with wide QRS complexes due to aberrant conduction or intraventricular block superficially resembling a ventricular tachycardia, ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.654.229

    authors: Warrington SJ,Hamer J

    更新日期:1980-04-01 00:00:00

  • Why paleomedicine is useful for medical education.

    abstract::What is the place of medico-historical cases in the professional practice of the disciplinary field of medicine and biology? How can these patients from the past be used for teaching and continuing medical education? How to justify their place in biomedical publications? In this article, we explain all the legitimacy ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2020-137804

    authors: Charlier P,Donnell S,Lippi D,Nerlich A,Asensi V,Perciaccante A,Appenzeller O,Bianucci R

    更新日期:2021-02-01 00:00:00

  • UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data.

    abstract:PURPOSE OF STUDY:The aim of the study is to describe the prevalence of illicit drug use in England and Wales using data from the UK Survey of Non-Medical Use of Prescription Drugs (NMURx) programme and to compare against the well-established Crime Survey England and Wales (CSEW). The rationale is that recreational and ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135798

    authors: Ng FL,Rockhill K,Black J,May KP,Whittington MD,Wood DM,Dargan PI,Green JL

    更新日期:2018-11-01 00:00:00

  • Hypertension in the West Indies.

    abstract::Hypertension is the most common chronic disease in the West Indies, and is a major health problem today being among the 10 most common causes of death in the English-speaking territories of the region. Most patients have essential hypertension. Renal failure, stroke, and cardiac failure are the most common complicatio...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.696.616

    authors: Grell GA

    更新日期:1983-10-01 00:00:00

  • Retroperitoneal lymphadenopathy in familial Mediterranean fever.

    abstract::Peripheral lymphadenopathy is rarely observed, whereas mesenteric lymphadenopathy is found occasionally on laparotomies in patients with familial Mediterranean fever (FMF). Retroperitoneal lymphadenopathy was reported only once in an autopsy of a patient with FMF. Our case is the second one, and the first one to be di...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.65.768.776

    authors: Rimon D,Meir Y,Cohen L

    更新日期:1989-10-01 00:00:00

  • Profiles of calcium antagonists in cardiovascular disease with special reference to second-generation agents and amlodipine.

    abstract::The majority of second-generation calcium antagonists are dihydropyridines, some of which show vascular selectivity. Several new dihydropyridines have been developed with comparable pharmacodynamic properties to existing calcium antagonists in this class and greatly improved kinetic half-lives. Of these agents, amlodi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Opie LH

    更新日期:1991-01-01 00:00:00

  • Psychiatric morbidity in primary hyperparathyroidism.

    abstract::Psychiatric symptoms are well recognized as a feature of patients with primary hyperparathyroidism. We have applied a standardized psychiatric interview to 15 patients before and after surgery. Thirteen had a lower 'psychiatric score' (less psychiatric morbidity) after surgery and improvements were particularly seen i...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.767.628

    authors: McAllion SJ,Paterson CR

    更新日期:1989-09-01 00:00:00

  • Multiple lymphomatous polyposis and the role of fine needle aspiration cytology.

    abstract::Multiple lymphomatous polyposis is an uncommon but distinctive form of gastrointestinal lymphoma. Clinical symptoms may closely resemble those of colorectal carcinoma and diagnostic confusion may result. The condition has a characteristic pathological appearance and immunophenotype which is important in allowing disti...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.69.811.401

    authors: Carder PJ,Gouldesbrough DR

    更新日期:1993-05-01 00:00:00

  • Localisation of the cricothyroid membrane by digital palpation in the emergency department.

    abstract:INTRODUCTION:A surgical approach to airway management may be essential in situations of difficult or failed airway, where immediate airway access is needed to provide oxygenation. However, the procedure is uncommonly performed and expertise among emergency clinicians may be limited. OBJECTIVES:The aim of this study wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135828

    authors: Alshareef H,Al Saawi A,Almazroua F,Alyami H,Reilly GO,Mitra B

    更新日期:2018-08-01 00:00:00

  • Management of acute ventilatory failure.

    abstract::Acute ventilatory failure is a challenging yet increasingly common medical emergency reflecting the growing burden of respiratory disease. It is not a diagnosis in itself but the end result of a diversity of disease processes culminating in arterial hypoxaemia and hypercapnia. This review focuses on key management iss...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.043208

    authors: Chakrabarti B,Calverley PM

    更新日期:2006-07-01 00:00:00

  • Ovarian carcinoma presenting as pyrexia of unknown origin.

    abstract::A patient with a poorly differentiated clear cell adenocarcinoma of the ovary presenting as pyrexia of unknown origin is reported. Following resection of the tumour, her pyrexia resolved completely. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.712.177

    authors: Schofield PM,Kirsop BA,Reginald P,Harington M

    更新日期:1985-02-01 00:00:00

  • The changing context of undergraduate medical education.

    abstract::It has long been recognised that intensive efforts are needed to reform medical education in order to meet the future needs of populations worldwide. Pressure for changes to the organisation, content and delivery of both undergraduate and postgraduate medical education has greatly increased in the last two decades. Th...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.837.397

    authors: Parsell GJ,Bligh J

    更新日期:1995-07-01 00:00:00

  • Recurrent thrombosis and anticardiolipin antibodies associated with adenocarcinoma of the lung.

    abstract::A case of adenocarcinoma of the lung, in which high titre anticardiolipin antibodies were associated with recurrent venous thromboses resistant to all forms of therapy, is described. It is suggested that such an autoimmune response may be a contributory factor in the para-neoplastic development of vascular thromboses....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.774.316

    authors: Shaukat MN,Hughes P

    更新日期:1990-04-01 00:00:00

  • Barriers to physical activity in patients with diabetes.

    abstract:PURPOSE:Two questions were addressed: (1) How much physical activity do patients with diabetes perform? (2) What are the perceived factors that prevent patients from doing more physical activity? RESEARCH DESIGN AND METHODS:Interview based questionnaires were distributed to consecutive patients attending the Diabetes ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2003.010553

    authors: Thomas N,Alder E,Leese GP

    更新日期:2004-05-01 00:00:00

  • Gall-bladder polyps in Peutz-Jeghers syndrome.

    abstract::A case of Peutz-Jeghers syndrome with polyps in the gall bladder is presented. No previous description of this finding has been reported. The literature regarding known sites of polyposis in this condition is reviewed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.56.655.373

    authors: Foster DR,Foster DB

    更新日期:1980-05-01 00:00:00

  • Ulcerative colitis and sarcoidosis.

    abstract::Ulcerative colitis is not commonly associated with recognizable pulmonary disease and only four sporadic cases of sarcoidosis in association with ulcerative colitis have been previously reported. However, in a series of 680 patients with ulcerative colitis, pulmonary or extra-pulmonary sarcoidosis has at some stage be...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.62.727.341

    authors: Barr GD,Shale DJ,Jewell DP

    更新日期:1986-05-01 00:00:00

  • Azathioprine in chronic relapsing idiopathic polyneuropathy.

    abstract::A 33-year-old housewife with a 14-year history of relapsing polyneuropathy of unknown cause who has apparently responded to azathioprine therapy is described. The place of this form of treatment in idiopathic polyneuropathy is discussed. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.660.734

    authors: Pentland B

    更新日期:1980-10-01 00:00:00

  • Digoxin: its role in contemporary medicine.

    abstract::Digoxin has been a key therapeutic for heart failure and atrial tachyarrhythmias for over 200 years following Withering's groundbreaking work depicting the therapeutic benefit of the common botanical foxglove in his 1785 monograph. The use of digoxin preceded any randomised evidence or even basic understanding of its ...

    journal_title:Postgraduate medical journal

    pub_type: 历史文章,杂志文章,评审

    doi:10.1136/postgradmedj-2014-132937

    authors: Stucky MA,Goldberger ZD

    更新日期:2015-09-01 00:00:00

  • Antibiotic prescription for patients referred to a specialist breast clinic.

    abstract::Hospital referral is indicated as an emergency for breast infections not settling with oral antibiotics. Referrals to a breast clinic over a period of 6 months were assessed for prior antibiotic prescription. A total of 1078 patients were seen during this period. 91 (8%) patients had been prescribed antibiotics, 71% o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.049296

    authors: Twine C,Gateley CA

    更新日期:2006-11-01 00:00:00

  • Abdominal epilepsy misdiagnosed as psychogenic pain.

    abstract::The authors present the case report of a child with abdominal epilepsy who had suffered from abdominal pain for several months under the label of psychogenic pain. The important historical clues were pallor and cold sweating during the paroxysm, followed by lethargy and prolonged sleep. An abnormal electroencephalogra...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.750.281

    authors: Singhi PD,Kaur S

    更新日期:1988-04-01 00:00:00

  • The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.

    abstract::The anti-hypertensive effect of 250 mg tienilic acid was comparable to that of 50 mg hydrochlorothiazide. Unlike hydrochlorothiazide, tienilic acid caused a statistically significant decrease in the serum uric acid values. Clinically non-significant rises in blood urea nitrogen and serum creatinine occurred with both ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: McMahon FG,Ryan JR,Jain AK

    更新日期:1979-01-01 00:00:00

  • Sinoatrial block complicating legionnaire's disease.

    abstract::A 59 year old woman presented with acute onset of fever, chills, diaphoresis, vague chest discomfort, and was found to be hypotensive and tachypnoeic. An electrocardiogram demonstrated sinoatrial block with a junctional rhythm between 50 and 80 beats/min. All cultures were negative and imaging studies unrevealing. Her...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.79.937.657

    authors: Medarov B,Tongia S,Rossoff L

    更新日期:2003-11-01 00:00:00

  • Diabetes insipidus complicating myelofibrosis.

    abstract::A 68 year old man developed cranial diabetes insipidus 3 years after the diagnosis of myelofibrosis, coincident with a marked increase in nucleated cell count. No mass lesion was demonstrable on computed tomographic or magnetic resonance imaging. It is suggested that hypothalamic damage was caused by local infiltratio...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.759.36

    authors: Dornan TL,Gillett G,Jones PA,Jeffcoate WJ

    更新日期:1989-01-01 00:00:00

  • Tissue plasminogen activator in the treatment of superior vena caval thrombosis associated with parenteral nutrition.

    abstract::Two patients, one of whom was pregnant, developed superior vena caval thrombosis while receiving central parenteral nutrition. They were successfully treated with recombinant tissue plasminogen activator (t-PA). ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.775.398

    authors: Barclay GR,Allen K,Pennington CR

    更新日期:1990-05-01 00:00:00

  • Severe haemorrhage from a lumbar artery as a complication of percutaneous renal biopsy.

    abstract::A patient is described with severe haemorrhage from a lumbar artery following percutaneous renal biopsy. The exact source of haemorrhage in this previously unreported complication proved difficult to locate even at surgical exploration. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.711.69

    authors: Jamison MH,Coward RA

    更新日期:1985-01-01 00:00:00

  • Magnetic resonance imaging in fetal medicine: a pictorial review of current and developing indications.

    abstract::Improvements in magnetic resonance (MR) imaging now permit diagnostic images of the fetus to be obtained. Ultrasound remains vital in all aspects of fetal imaging but MR provides a useful second line imaging test. Its value is best researched in fetal central nervous system disorders but it can be applied in other are...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2009.083543

    authors: Weston MJ

    更新日期:2010-01-01 00:00:00

  • Lifestyle medicine course for family medicine residents: preliminary assessment of the impact on knowledge, attitudes, self-efficacy and personal health.

    abstract:PURPOSE:The WHO estimates that by 2020 two-thirds of the diseases worldwide will be the result of unhealthy lifestyle habits. Less than half of primary care physician graduates feel prepared to give lifestyle behaviour counselling. Our objective was to evaluate the impact of lifestyle medicine (LM) course on self-repor...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.1136/postgradmedj-2016-134726

    authors: Malatskey L,Bar Zeev Y,Tzuk-Onn A,Polak R

    更新日期:2017-09-01 00:00:00

  • Direct assessment of gastrointestinal inflammation and mucosal immunity in children with cystic fibrosis.

    abstract::Fibrosing colonopathy is a recently described complication of cystic fibrosis, of unknown aetiology but possibly related to treatment with high-dose pancreatic enzyme supplements. We have used a whole gut perfusion technique to study subclinical gut inflammation in cystic fibrosis patients; concentrations of haemoglob...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Croft NM,Marshall TG,Ferguson A

    更新日期:1996-03-01 00:00:00

  • Neurological complications of human immunodeficiency virus infection.

    abstract::The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.64.749.180

    authors: Kennedy PG

    更新日期:1988-03-01 00:00:00