Digoxin: its role in contemporary medicine.

Abstract:

:Digoxin has been a key therapeutic for heart failure and atrial tachyarrhythmias for over 200 years following Withering's groundbreaking work depicting the therapeutic benefit of the common botanical foxglove in his 1785 monograph. The use of digoxin preceded any randomised evidence or even basic understanding of its mechanism of action. Over the past two decades, there has been mounting evidence further challenging the safety and efficacy of digoxin, while multiple other therapies for both heart failure and atrial tachyarrhythmias have proven to be more effective and safe. Altogether, digoxin still has an important role in contemporary pharmacotherapeutics, though its role remains controversial and should be reserved for selective patients and clinical situations, with careful attention to serum concentrations.

journal_name

Postgrad Med J

authors

Stucky MA,Goldberger ZD

doi

10.1136/postgradmedj-2014-132937

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

514-8

issue

1079

eissn

0032-5473

issn

1469-0756

pii

postgradmedj-2014-132937

journal_volume

91

pub_type

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