Genetic testing in cardiovascular diseases.

abstract：PURPOSE OF REVIEW:Atrial fibrillation is an important cause of morbidity in the aging population. The mechanisms responsible for the triggering and maintenance of the chaotic atrial rhythm are still poorly understood. In this review, we will focus on the genetic aspects of atrial fibrillation, to understand causality, ...

journal_title：Current opinion in cardiology

authors： Pérez-Serra A,Campuzano O,Brugada R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize changing paradigms and perceptions in the prevention and treatment of cardiovascular disease. RECENT FINDINGS:Recent studies have shown that arterial inflammation probably plays a key role in the development and progression of atherosclerosis, that acute myocardial infarctions often evol...

journal_title：Current opinion in cardiology

authors： Franklin BA,Trivax JE,Vanhecke TE

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on high-density lipoprotein (HDL) biology and emerging new HDL-based therapies for athero-thrombosis. RECENT FINDINGS:Atherosclerotic cardiovascular disease remains a major public health threat despite a significant decline over the past three decades. Although current medical th...

journal_title：Current opinion in cardiology

authors： Shah PK

更新日期：2010-11-01 00:00:00

abstract：:The therapeutic benefits of angiotensin-converting enzyme inhibitors in the treatment of hypertension, congestive heart failure, and atherosclerotic heart disease are undeniable. Recent studies, however, suggest that the cardioprotective effect produced by these drugs is complex and may not be solely related to inhibi...

journal_title：Current opinion in cardiology

authors： Ferrario CM,Chappell MC

更新日期：1994-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Since the last few years, three-dimensional echocardiography (3DE) has become an accurate tool for mitral stenosis assessment. We will review the latest developments of 3DE in this matter. RECENT FINDINGS:Accuracy of 3DE planimetry is superior to the accuracy of the invasive Gorlin's method for mitra...

journal_title：Current opinion in cardiology

authors： Zamorano J,de Agustín JA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac transplantation is a recognized therapy for end-stage heart failure. Graft coronary artery disease is a chief determinant of long-term survival following cardiac transplantation. There are multiple purported etiologies for graft coronary artery disease including both immunologic and nonimmunol...

journal_title：Current opinion in cardiology

authors： Kass M,Haddad H

更新日期：2006-03-01 00:00:00

abstract：:A trend toward use of less invasive, nonsurgical approaches to the treatment of congenital heart disease has developed. Although transcatheter valve replacements and ventricular septal defect closures have already been performed in children, many other techniques and devices are being developed for the palliation of c...

journal_title：Current opinion in cardiology

authors： Levi DS,Alejos JC,Moore JW

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Body habitus is a key lifestyle characteristic whose current status and future projections are disconcerting. The percentage of the global population who are either overweight or obese has substantially increased, with no indication that any country has a solution to this issue. Hypertension is a key ...

journal_title：Current opinion in cardiology

authors： Arena R,Daugherty J,Bond S,Lavie CJ,Phillips S,Borghi-Silva A

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the role of statin therapy in patients with acute coronary syndromes. These drugs modulate endothelial function and stabilize atherosclerotic plaque by inhibiting oxidative stress and inflammation and may provide a relevant clinical benefit in unstable patients. RECENT FINDINGS:...

journal_title：Current opinion in cardiology

authors： Nusca A,Melfi R,Patti G,Di Sciascio G

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Our understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic basis of congenital heart disease. Along with the discovery of specific genes that cause lesions, recent research has focused on the interactions of some previousl...

journal_title：Current opinion in cardiology

authors： Wolf M,Basson CT

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The emerging role of stress and particularly exercise echocardiography in mitral regurgitation has been recently emphasized. In fact, the evaluation of mitral regurgitation only under resting conditions might underestimate the full impact of the lesion and its clinical effects. RECENT FINDINGS:Exerci...

journal_title：Current opinion in cardiology

authors： Lancellotti P,Magne J

更新日期：2012-09-01 00:00:00

abstract：:Ventricular remodeling refers to changes in ventricular geometry, volume, mass, and myocellular structure in response to myocardial injury or alteration in loading conditions. Although initially adaptive as a consequence of the initial damage to the myocardium, progressive ventricular remodeling is ultimately a malada...

journal_title：Current opinion in cardiology

authors： Bozkurt B

更新日期：1999-05-01 00:00:00

abstract：:Implantable cardioverter defibrillators (ICDs) have become an important therapeutic modality for patients who have had a cardiac arrest or are at risk for life-threatening ventricular arrhythmias. Clinical trials have confirmed the role of the ICD for patients with sustained ventricular arrhythmias and have expanded t...

journal_title：Current opinion in cardiology

authors： Swygman C,Wang PJ,Link MS,Homoud MK,Estes NA 3rd

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system. RECENT FINDINGS:Recent studies suggest that cGMP, which serves ...

journal_title：Current opinion in cardiology

authors： Jordan J,Hildebrand S,Pfeifer A

更新日期：2019-07-01 00:00:00

abstract：:Increased carotid intima media thickness (IMT) is relatively simple, inexpensive, and reproducible noninvasive marker of global atherosclerotic disease. It is a frequently used experimental tool in epidemiologic studies to identify and follow cardiovascular disease. There is evidence that early detection of atheroscle...

journal_title：Current opinion in cardiology

authors： Sinha AK,Eigenbrodt M,Mehta JL

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. RECENT FINDINGS:A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatm...

journal_title：Current opinion in cardiology

authors： Yanagawa B,Tam DY,Mazine A,Tricco AC

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The new pandemic of coronavirus disease-2019 (COVID-19) has produced a global tumult and has overburdened national health systems. We herein discuss the cardiovascular implications and complications of this pandemic analyzing the most recent data clustered over the last several months. RECENT FINDING...

journal_title：Current opinion in cardiology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-12-30 00:00:00

abstract：:A growing number of patients present with heart failure. Some of them may qualify for surgical correction of their cardiac condition. Since heart transplantation will always be available to only a small number of patients, several new surgical techniques have been developed for approval in heart failure patients. Clas...

journal_title：Current opinion in cardiology

authors： Loebe M,Soltero E,Thohan V,Lafuente JA,Noon GP

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although antiplatelet agents are frequently prescribed to patients with lower extremity peripheral artery disease (PAD), there is an overall lack of consensus among published evidence and guidelines with respect to this practice. RECENT FINDINGS:Antiplatelet agents are prescribed to patients with PAD...

journal_title：Current opinion in cardiology

authors： Banerjee S,Sarode K,Vinas A,Banerjee A,Mohammad A,Brilakis ES

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:New data have emerged over the last few years about the role of fibrates in treatment of microvascular and macrovascular disease. RECENT FINDINGS:Endpoint studies have been conducted with fibrates in coronary heart disease (CHD) since 1971 and initial results were contradictory. Fibrates later showed benefits ...

journal_title：Current opinion in cardiology

authors： Wierzbicki AS

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Transcatheter aortic-valve implantation is a promising new treatment modality for patients with aortic-valve disease, where it may revolutionize the treatment of elderly and high-risk patients. RECENT FINDINGS:The two devices currently available, the Edwards Sapien valve and the Medtronic CoreValve s...

journal_title：Current opinion in cardiology

authors： Ruel M,Labinaz M

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the application of next-generation sequencing (NGS) technologies in the identification of the causation of nonsyndromic genetic cardiomyopathies. RECENT FINDINGS:NGS sequencing of the entire genetic coding sequence (the exome) has successfully identified five novel genes and caus...

journal_title：Current opinion in cardiology

authors： Norton N,Li D,Hershberger RE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart failure is a worldwide epidemic. Aggressive treatment of patients at risk for heart failure is important. There are no trials targeting primary prevention of heart failure. However, there is trial data demonstrating that treatment of patients with atherosclerotic vascular disease, hypertension, ...

journal_title：Current opinion in cardiology

authors： Dupree CS

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular disease often affects more than one territory. Atherosclerosis is a global disease affecting multiple organs/systems. Cardiovascular risk factors are associated with an increased risk for the development of arterial disease in all vascular beds but differ in their individual impacts for each ...

journal_title：Current opinion in cardiology

authors： Paraskevas KI,Geroulakos G,Veith FJ,Mikhailidis DP

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite progressive improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart abnormalities with the greatest morbidity and mortality. Hybrid approaches to management, combining surgical and interventional catheterization procedures, have been introduced to m...

journal_title：Current opinion in cardiology

authors： Gutgesell HP,Lim DS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:A low level of plasma high density lipoprotein cholesterol (HDL-C) is a strong and independent risk factor for atherosclerotic cardiovascular disease (ASCVD). However, several large studies recently revealed that pharmacologic interventions that increase HDL-C concentration have not improved cardiovas...

journal_title：Current opinion in cardiology

authors： Siddiqi HK,Kiss D,Rader D

更新日期：2015-09-01 00:00:00

abstract：:This review describes to date the experience with combined heart-kidney transplant (HNTx) from a single donor. HNTxs are very uncommon relative to single-organ transplants of the heart and kidney, as well as combined kidney-pancreas and combined kidney-liver transplants. Two groups of patients seem to be candidates fo...

journal_title：Current opinion in cardiology

authors： Castillo-Lugo JA,Brinker KR

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of clinically available genetic tests for heritable cardiovascular diseases has recently increased because of novel gene discoveries and advancements in DNA sequencing technologies. The purpose of this review is to provide up-to-date genetic testing information and guidance on how to incorp...

journal_title：Current opinion in cardiology

authors： Sturm AC,Hershberger RE

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in patients with mild-to-severe heart failure. However, up to 40% of CRT recipients are nonresponders. This review addresses important aspects with regard to the identification and management of CRT nonresponders. RECENT FINDINGS...

journal_title：Current opinion in cardiology

authors： Zhang Q,Zhou Y,Yu CM

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial tortuosity is emerging as a common feature in genetically mediated thoracic aortic disease that may be prognostic. This review will summarize recent literature on arterial tortuosity in the setting of genetic arteriopathies. RECENT FINDINGS:Although arterial tortuosity has been primarily des...

journal_title：Current opinion in cardiology

authors： Morris SA

更新日期：2015-11-01 00:00:00