The role of antiplatelet therapy in patients with peripheral artery disease and lower extremity peripheral artery revascularization.

Abstract:

PURPOSE OF REVIEW:Although antiplatelet agents are frequently prescribed to patients with lower extremity peripheral artery disease (PAD), there is an overall lack of consensus among published evidence and guidelines with respect to this practice. RECENT FINDINGS:Antiplatelet agents are prescribed to patients with PAD to reduce both cardiovascular and limb-based events during the follow-up period. A large evidence base supports the use of antiplatelet monotherapy with aspirin or clopidogrel in patients with symptomatic PAD or a history of peripheral artery revascularization. However, antiplatelet monotherapy has not proven beneficial in patients with asymptomatic PAD. Dual antiplatelet therapy has not demonstrated a clear benefit in reducing the risk of cardiovascular events in patients with symptomatic PAD. Its role in reducing the risk of adverse limb events following endovascular or surgical revascularization also remains unclear. Recently, the use of vorapaxar in addition to aspirin and/or clopidogrel has been associated with a significant reduction in the need for repeat revascularization procedures and hospitalization for limb ischemia in patients with established PAD. SUMMARY:Eligible patients with symptomatic PAD or with a history of peripheral artery revascularization should be prescribed antiplatelet monotherapy for secondary prevention of both cardiovascular and limb events, using aspirin, clopidogrel, and/or vorapaxar. Given the significant overlap of PAD and coronary artery disease, the evidence presented in this article may have important implications for management of patients with coronary artery disease.

journal_name

Curr Opin Cardiol

authors

Banerjee S,Sarode K,Vinas A,Banerjee A,Mohammad A,Brilakis ES

doi

10.1097/HCO.0000000000000208

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

525-35

issue

5

eissn

0268-4705

issn

1531-7080

journal_volume

30

pub_type

杂志文章,评审
  • Role of catheter ablation for supraventricular tachyarrhythmias, with emphasis on atrial flutter and atrial tachycardia.

    abstract::Catheter ablation techniques using radiofrequency current have become an accepted form of treatment for a variety of supraventricular tachycardias. The results are excellent in patients with preexcitation syndromes and as the complication rate is low, catheter ablation has become the first line of treatment for these ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199401000-00006

    authors: Haissaguerre M,Saoudi N

    更新日期:1994-01-01 00:00:00

  • Emerging clinical roles for ambulatory blood pressure monitoring.

    abstract::Ambulatory blood pressure monitoring is becoming increasingly popular in the diagnosis and treatment of patients with hypertensive disorders. Widespread clinical use, however, has been limited by a lack of normative data and prospective, controlled clinical studies of its impact on subsequent cardiovascular morbidity ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199309000-00007

    authors: Canzanello VJ,Sheps SG

    更新日期:1993-09-01 00:00:00

  • Statins and kidney disease: is the study of heart and renal protection at the cutting edge of evidence?

    abstract:PURPOSE OF REVIEW:Dyslipidaemias are noted in all stages of chronic kidney disease (CKD). Currently most evidence for their treatment comes from secondary retrospective analyses of patient subgroups with CKD recruited into clinical trials powered of hypertensive and dyslipideamic cohorts powered for cardiovascular endp...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328353b988

    authors: Jenkins M,Goldsmith D

    更新日期:2012-07-01 00:00:00

  • Imaging and heart failure: myocardial strain.

    abstract:PURPOSE OF REVIEW:To summarize literature on the application of myocardial strain in patients with heart failure published since 2018. RECENT FINDINGS:Left ventricular (LV) and right ventricular strain provides important prognostic information in patients with acute and chronic heart failure and new insights in diseas...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000653

    authors: Edvardsen T,Klaeboe LG

    更新日期:2019-09-01 00:00:00

  • Cardiovascular implications and complications of the coronavirus disease-2019 pandemic: a world upside down.

    abstract:PURPOSE OF REVIEW:The new pandemic of coronavirus disease-2019 (COVID-19) has produced a global tumult and has overburdened national health systems. We herein discuss the cardiovascular implications and complications of this pandemic analyzing the most recent data clustered over the last several months. RECENT FINDING...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000838

    authors: Manolis AS,Manolis TA,Manolis AA,Melita H

    更新日期:2020-12-30 00:00:00

  • Recent advances in cardiac magnetic resonance imaging.

    abstract::Magnetic resonance imaging of the cardiovascular system is now a well-recognized primary investigative technique for many conditions of structural abnormality in clinical cardiology, but the assessment of functional abnormality is also valuable and is increasingly being recognized by clinicians because of the accuracy...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199611000-00013

    authors: Taylor AM,Pennell DJ

    更新日期:1996-11-01 00:00:00

  • Three-dimensional echocardiography for assessment of mitral valve stenosis.

    abstract:PURPOSE OF REVIEW:Since the last few years, three-dimensional echocardiography (3DE) has become an accurate tool for mitral stenosis assessment. We will review the latest developments of 3DE in this matter. RECENT FINDINGS:Accuracy of 3DE planimetry is superior to the accuracy of the invasive Gorlin's method for mitra...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832e165b

    authors: Zamorano J,de Agustín JA

    更新日期:2009-09-01 00:00:00

  • Long-term results of coronary artery bypass grafting.

    abstract::The treatment of ischemic heart disease by coronary artery bypass grafting remains under intense scrutiny. A better understanding of the long-term outcome for particular patient subgroups will allow a more appropriate choice to be made among the options of coronary artery bypass grafting, angioplasty, or continued med...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199611000-00003

    authors: Kanagasabay RR,Parker DJ

    更新日期:1996-11-01 00:00:00

  • The total artificial heart for biventricular heart failure and beyond.

    abstract:PURPOSE OF REVIEW:Treatment options for late-stage biventricular heart failure are limited but include medical therapy with intravenous inotropes, biventricular assist devices (Bi-VADs) and the total artificial heart (TAH). In this manuscript, we review the indications, surgical techniques and outcomes for the TAH. RE...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32835220c9

    authors: Kasirajan V,Tang DG,Katlaps GJ,Shah KB

    更新日期:2012-05-01 00:00:00

  • Cybersecurity threats to cardiac implantable devices: room for improvement.

    abstract:PURPOSE OF REVIEW:For over a decade, vulnerabilities in the healthcare industry have been identified. Medical devices such as cardiovascular implantable electronic devices (CIEDs) are particularly concerning because of direct threats to patient safety and protected health information (PHI). Although these vulnerabiliti...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000815

    authors: Tomaiko E,Zawaneh MS

    更新日期:2021-01-01 00:00:00

  • Evidence supporting secondary prevention strategies.

    abstract::Currently 14 million individuals in the United States have coronary disease. Within the next 2 decades, this number is expected to increase to 21 million persons. To minimize the excessive risk of recurrent cardiac events in these people, evidence-based, cost-effective prevention strategies must be developed. This rev...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199907000-00005

    authors: Blazing MA,O'Connor CM

    更新日期:1999-07-01 00:00:00

  • Medical and surgical therapy for cardiac remodeling.

    abstract::Ventricular remodeling refers to changes in ventricular geometry, volume, mass, and myocellular structure in response to myocardial injury or alteration in loading conditions. Although initially adaptive as a consequence of the initial damage to the myocardium, progressive ventricular remodeling is ultimately a malada...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199905000-00002

    authors: Bozkurt B

    更新日期:1999-05-01 00:00:00

  • Transcatheter device closure of atrial septal defects: more to think about than just closing the hole.

    abstract:PURPOSE OF REVIEW:To review current controversies in the transcatheter device closure of ostium secundum atrial septal defects (ASD). RECENT FINDINGS:Transcatheter device closure of ASD (TC-ASD) has well established efficacy and safety. For most individual patients with suitable anatomy, TC-ASD is the preferred method...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000476

    authors: O'Byrne ML,Glatz AC,Gillespie MJ

    更新日期:2018-01-01 00:00:00

  • Lipoprotein a: where are we now?

    abstract:PURPOSE OF REVIEW:To provide an update of the literature describing the link between lipoprotein a and vascular disease. RECENT FINDINGS:There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis. Several mechanisms may be ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32832ac21a

    authors: Tziomalos K,Athyros VG,Wierzbicki AS,Mikhailidis DP

    更新日期:2009-07-01 00:00:00

  • Thrombolytic therapy in acute pulmonary embolism.

    abstract:PURPOSE OF REVIEW:The goal of this review is to offer an overview of the use of thrombolytic therapy in acute pulmonary embolism. Clinicians including internists, surgeons, pulmonologists, and other specialists continue to face decisions regarding massive and submassive acute pulmonary embolism in their daily routines....

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e328358308c

    authors: Tapson VF

    更新日期:2012-11-01 00:00:00

  • Endocarditis.

    abstract::Endocarditis remains a major worldwide problem despite significant advances in diagnostic and therapeutic interventions. This review centers on the recent studies that have been published in the past year concerning the epidemiologic, diagnostic, and therapeutic aspects of infective and noninfective endocarditis in bo...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199703000-00006

    authors: Farmer JA,Torre G

    更新日期:1997-03-01 00:00:00

  • Association between hematological parameters and high-density lipoprotein cholesterol.

    abstract:PURPOSE OF REVIEW:The ability of high-density lipoprotein cholesterol to reverse atherosclerosis and reduce cardiovascular disease has been shown in several randomized controlled trials. One mechanism by which high-density lipoprotein cholesterol protects the vascular system includes hemorheology, the study of blood fl...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/01.hco.0000167722.22453.47

    authors: Moriarty PM,Gibson CA

    更新日期:2005-07-01 00:00:00

  • The inflammatory response to cardiopulmonary bypass and its impact on postoperative myocardial function.

    abstract::Cardiopulmonary bypass triggers a generalized inflammatory response that is largely mediated by activation of polymorphonuclear neutrophils, their adhesion to endothelial cells, and the subsequent release of cytotoxic products. It has been known for several years that the inflammatory response to extracorporeal circul...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Menasché P

    更新日期:1995-11-01 00:00:00

  • Genetic cardiomyopathies.

    abstract:PURPOSE OF REVIEW:To describe recent advancements in cardiovascular genetics made possible by leveraging next-generation sequencing (NGS), and to provide a framework for practical applications of genetic testing for hypertrophic (HCM), dilated (DCM), and arrhythmogenic right ventricular cardiomyopathies (ARVC). RECENT...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000512

    authors: Wilcox JE,Hershberger RE

    更新日期:2018-05-01 00:00:00

  • New or developing antihypertensive agents.

    abstract::Although significant pharmacologic and nonpharmacologic advances in treating hypertension during the last decade have reduced mortality and morbidity, hypertension continues to be a major health concern worldwide. Therefore, the search continues for newer specific pharmacologic treatment of this disorder. This review ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:

    authors: Evans RR,DiPette DJ

    更新日期:1997-07-01 00:00:00

  • Are statins diabetogenic?

    abstract:PURPOSE OF REVIEW:Statins are widely utilized for low-density lipoprotein lowering and for prevention of atherosclerotic cardiovascular disease. Although these drugs have a good safety record, increased risk of developing diabetes during extended use has recently garnered attention. Here we review clinical trial eviden...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e3283470359

    authors: Sampson UK,Linton MF,Fazio S

    更新日期:2011-07-01 00:00:00

  • Systematic review and meta-analysis in cardiac surgery: a primer.

    abstract:PURPOSE OF REVIEW:The purpose of this article is to review the strengths and weaknesses of systematic reviews and meta-analyses to inform our current understanding of cardiac surgery. RECENT FINDINGS:A systematic review and meta-analysis of a focused topic can provide a quantitative estimate for the effect of a treatm...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1097/HCO.0000000000000496

    authors: Yanagawa B,Tam DY,Mazine A,Tricco AC

    更新日期:2018-03-01 00:00:00

  • Multifocal arterial disease: clinical implications and management.

    abstract:PURPOSE OF REVIEW:Vascular disease often affects more than one territory. Atherosclerosis is a global disease affecting multiple organs/systems. Cardiovascular risk factors are associated with an increased risk for the development of arterial disease in all vascular beds but differ in their individual impacts for each ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章

    doi:10.1097/HCO.0000000000000746

    authors: Paraskevas KI,Geroulakos G,Veith FJ,Mikhailidis DP

    更新日期:2020-07-01 00:00:00

  • Health benefits of physical activity: a systematic review of current systematic reviews.

    abstract:PURPOSE OF REVIEW:The health benefits of physical activity and exercise are clear; virtually everyone can benefit from becoming more physically active. Most international guidelines recommend a goal of 150 min/week of moderate-to-vigorous intensity physical activity. Many agencies have translated these recommendations ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000437

    authors: Warburton DER,Bredin SSD

    更新日期:2017-09-01 00:00:00

  • Three-dimensional echocardiography.

    abstract::Three-dimensional echocardiography depicts the heart and its structures in their realistic forms. This capability decreases variability both in the quality and the interpretation of complex pathology, among investigators. Therefore, it is likely that the method will become the standard echocardiography examination in ...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-199811000-00002

    authors: Roelandt JR,Yao J,Kasprzak JD

    更新日期:1998-11-01 00:00:00

  • Biventricular pacing in congestive heart failure: a boost toward finer living.

    abstract::With 550,000 new cases each year, congestive heart failure is a major medical problem. Several medical therapies, including digoxin, angiotensin-converting enzyme inhibitors, and beta-blockers, have reduced the number of re-hospitalizations and slowed the progression of congestive heart failure. Angiotensin-converting...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/00001573-200201000-00014

    authors: Luck JC,Wolbrette DL,Boehmer JP,Ulsh PJ,Silber D,Naccarelli GV

    更新日期:2002-01-01 00:00:00

  • Outcomes in single versus bilateral internal thoracic artery grafting in coronary artery bypass surgery.

    abstract::The authors analyzed the early outcomes in two groups of patients undergoing coronary artery bypass grafting (CABG) with single versus bilateral internal thoracic arteries (ITA) in their institution. One thousand sixty-nine patients underwent CABG with single or bilateral ITAs from 1990 to 2000. Of these patients, 911...

    journal_title:Current opinion in cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00001573-200211000-00003

    authors: Walkes JC,Earle N,Reardon MJ,Glaeser DH,Wall MJ Jr,Huh J,Jones JW,Soltero ER

    更新日期:2002-11-01 00:00:00

  • Management of heart failure in the elderly.

    abstract:PURPOSE OF REVIEW:Heart failure is a major chronic illness with no definitive cure. With improving healthcare and with an aging population in many countries, heart failure has become a common disease of the elderly. Pharmacological management of heart failure in the elderly remains a challenge. The syndrome of heart fa...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0000000000000375

    authors: Alghamdi F,Chan M

    更新日期:2017-03-01 00:00:00

  • Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis.

    abstract:PURPOSE OF REVIEW:Myocardial fibrosis is a common feature of many cardiomyopathies, including hypertrophic cardiomyopathy. Myocardial fibrosis has been shown to be reversible and treatable with timely intervention. Although early detection and assessment of fibrosis is crucial, adequate diagnostics are still in develop...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32835f5a2b

    authors: Won S,Davies-Venn C,Liu S,Bluemke DA

    更新日期:2013-05-01 00:00:00

  • Genetics of Brugada syndrome.

    abstract:PURPOSE OF REVIEW:The Brugada syndrome has been investigated in depth since its description in 1992 both on a clinical and on a basic research level. Since the discovery of the first genetic defect in 1998, several genes have been subsequently identified. However, to date all these genes together explain only 30% of th...

    journal_title:Current opinion in cardiology

    pub_type: 杂志文章,评审

    doi:10.1097/HCO.0b013e32833846ee

    authors: Campuzano O,Brugada R,Iglesias A

    更新日期:2010-05-01 00:00:00