Association between hematological parameters and high-density lipoprotein cholesterol.

Abstract:

PURPOSE OF REVIEW:The ability of high-density lipoprotein cholesterol to reverse atherosclerosis and reduce cardiovascular disease has been shown in several randomized controlled trials. One mechanism by which high-density lipoprotein cholesterol protects the vascular system includes hemorheology, the study of blood flow. RECENT FINDINGS:Blood viscosity, or the resistance of flow, can be altered by red blood cell aggregation, red blood cell deformability, and plasma viscosity. Elevated high-density lipoprotein cholesterol levels may improve all of these rheological mediators. An infusion of recombinant high-density lipoprotein cholesterol can immediately release nitric oxide, a potent vasodilator and responder to changes in rheology, into the arteries by activation of endothelial nitric oxide synthase. The stimulation of nitric oxide release by high-density lipoprotein cholesterol may also alter blood rheology. SUMMARY:In this article, we will review hemorheology, particularly blood viscosity along with other hemorheological factors, and examine their association with high-density lipoprotein cholesterol.

journal_name

Curr Opin Cardiol

authors

Moriarty PM,Gibson CA

doi

10.1097/01.hco.0000167722.22453.47

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

318-23

issue

4

eissn

0268-4705

issn

1531-7080

pii

00001573-200507000-00015

journal_volume

20

pub_type

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