cGMP manipulation in cardiometabolic disease: chances and challenges.

Abstract:

PURPOSE OF REVIEW:Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system. RECENT FINDINGS:Recent studies suggest that cGMP, which serves as second messenger for nitric oxide and for natriuretic peptides, improves oxidative metabolism and insulin signaling. The clinical evidence is particularly strong for the natriuretic peptide branch of the cGMP system. Clinical trials suggested improvements in insulin sensitivity and reductions in the risk of progressing to type 2 diabetes mellitus. However, further studies are needed. SUMMARY:Enhancing cGMP signaling through nonpharmacological or pharmacological means may improve glucose metabolism in addition to affecting the cardiovascular system. However, excessive cGMP production could have significant unwanted cardiovascular and metabolic effects.

journal_name

Curr Opin Cardiol

authors

Jordan J,Hildebrand S,Pfeifer A

doi

10.1097/HCO.0000000000000630

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

376-383

issue

4

eissn

0268-4705

issn

1531-7080

journal_volume

34

pub_type

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