Selective antagonism of the rate-decreasing effect of d-amphetamine by chlorpromazine in a repeated-acquisition task.

Abstract:

:Pigeons acquired a different four-response chain each session by responding sequentially on three keys in the presence of four colors. The response chain was maintained by food presentation under a fixed-ratio schedule. When d-amphetamine was administered alone, the overall response rate decreased and the percent errors increased with increasing doses. When a small dose of chlorpromazine, which was ineffective when given alone, was administered in combination with d-amphetamine, the rate-decreasing effect was antagonized. The antagonism was selective, however, in that the error-increasing effect of d-amphetamine was augmented by chlorpromazine. The nature of the joint effect of the two drugs thus depended on the behavioral measure: rate vs. accuracy.

journal_name

J Exp Anal Behav

authors

Thompson DM

doi

10.1901/jeab.1980.34-87

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

87-92

issue

1

eissn

0022-5002

issn

1938-3711

journal_volume

34

pub_type

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