Abstract:
:Under multiple schedules of reinforcement, previous research has generally observed tolerance to the rate-decreasing effects of cocaine that has been dependent on schedule-parameter size in the context of fixed-ratio (FR) schedules, but not under the context of fixed-interval (FI) schedules of reinforcement. The current experiment examined the effects of cocaine on key-pecking responses of White Carneau pigeons maintained under a three-component multiple conjunctive FI (10 s, 30 s, & 120 s) FR (5 responses) schedule of food presentation. Dose-effect curves representing the effects of presession cocaine on responding were assessed in the context of (1) acute administration of cocaine (2) chronic administration of cocaine and (3) daily administration of saline. Chronic administration of cocaine generally resulted in tolerance to the response-rate decreasing effects of cocaine, and that tolerance was generally independent of relative FI value, as measured by changes in ED50 values. Daily administration of saline decreased ED50 values to those observed when cocaine was administered acutely. The results show that adding a FR requirement to FI schedules is not sufficient to produce schedule-parameter-specific tolerance. Tolerance to cocaine was generally independent of FI-parameter under the present conjunctive schedules, indicating that a ratio requirement, per se, is not sufficient for tolerance to be dependent on FI parameter.
journal_name
J Exp Anal Behavjournal_title
Journal of the experimental analysis of behaviorauthors
Yoon JH,Branch MNdoi
10.1901/jeab.2009.92-413subject
Has Abstractpub_date
2009-11-01 00:00:00pages
413-22issue
3eissn
0022-5002issn
1938-3711journal_volume
92pub_type
杂志文章abstract::Experiment I sought to determine if the stimulus correlated with extinction in a successive discrimination was an aversive stimulus. An escape response provided an index of aversive control. Two groups of pigeons were exposed to a multiple variable-interval 30-sec extinction schedule. For the experimental group, a sin...
journal_title:Journal of the experimental analysis of behavior
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journal_title:Journal of the experimental analysis of behavior
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journal_title:Journal of the experimental analysis of behavior
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1967-09-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1973-03-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1970-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1977-09-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1976-09-01 00:00:00
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更新日期:1989-01-01 00:00:00
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journal_title:Journal of the experimental analysis of behavior
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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