Abstract:
:T cells are known to interact cooperatively with monocytes to produce Colony-Stimulating Factors (CSF), although T cell-mediated signals leading to CSF secretion by monocytes are not completely understood. We have made use of Northern blot hybridization and specific bioassays to study the effects of the T cell product interleukin-4 (IL-4) on monocyte CSF expression. The results suggest a previously unrecognized role of IL-4 as a CSF inducer since exposure of monocytes to IL-4 resulted in accumulation of transcripts for granulocyte-CSF (G-CSF) and macrophage-CSF (M-CSF). Consequently, IL-4-activated monocytes released factors in their culture supernatants biologically and antigenically indistinguishable from G- and M-CSF.
journal_name
Bloodjournal_title
Bloodauthors
Wieser M,Bonifer R,Oster W,Lindemann A,Mertelsmann R,Herrmann Fsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
1105-8issue
5eissn
0006-4971issn
1528-0020journal_volume
73pub_type
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