Hypothesis: Tim-3/galectin-9, a new pathway for leukemia stem cells survival by promoting expansion of myeloid-derived suppressor cells and differentiating into tumor-associated macrophages.

abstract：:The objective is to explore the clinical curative effects of methylprednisolone combined with MTX and DXM intrathecal injection in treating neuropsychiatric systemic lupus erythematosus (NPSLE) and its effects on autoantibody level and anti-N-methyl-D-aspartate receptor subtype NR2a/2b antibody (anti-NR2 antibody) lev...

journal_title：Cell biochemistry and biophysics

authors： Wang J,Zhao Y,Zhang J,Lei H,Zhu G,Fu B

更新日期：2014-11-01 00:00:00

abstract：:The precise regulation of both the magnitude and the duration of Janus kinase (JAK) catalytic activity is essential for the cytokine orchestration of many biological processes, and the dysregulation of JAK activity has pathological implications. Immunosuppressive disease states, such as X-linked severe combined immuno...

journal_title：Cell biochemistry and biophysics

authors： Duhé RJ,Wang LH,Farrar WL

更新日期：2001-01-01 00:00:00

abstract：:Mechanics of cancer cells are directly linked to their metastatic potential, or ability to produce a secondary tumor at a distant site. Metastatic cells survive in the circulatory system in a non-adherent state, and can squeeze through barriers in the body. Such considerable structural changes in cells rely on rapid r...

journal_title：Cell biochemistry and biophysics

authors： Gal N,Weihs D

更新日期：2012-07-01 00:00:00

abstract：:Circumstantial evidence frequently implicates oxygen-derived free radicals and oxidative stress as mediators of myocardial ischemia/reperfusion (I/R) injury. Therefore, external supplementation of natural antioxidants plays a main role as cardioprotective compounds. This study was designed to evaluate the cardioprotec...

journal_title：Cell biochemistry and biophysics

authors： Adluri RS,Thirunavukkarasu M,Zhan L,Maulik N,Svennevig K,Bagchi M,Maulik G

更新日期：2013-11-01 00:00:00

abstract：:In the present study, the changes of the regulatory T cells (Treg) expression, endotoxin translocation, and the relationships in intestinal lymph nodes were investigated in porcine sepsis induced by severe burns. Flow cytometry, western blot, and Tachypleus amebocyte lysate were applied to study after the burn injury ...

journal_title：Cell biochemistry and biophysics

authors： Zu H,Li Q,Huang P

更新日期：2014-12-01 00:00:00

abstract：:Cellular responses to external signals often reflect alterations in gene expression. The activation of cell surface hormone or growth factor receptors upon the binding of appropriate ligands mobilizes signal transduction cascades that can ultimately impact the activity of defined sets of transcription factors. The int...

journal_title：Cell biochemistry and biophysics

authors： DeFranco DB

更新日期：1999-01-01 00:00:00

abstract：:Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefo...

journal_title：Cell biochemistry and biophysics

authors： Sahin DS,Tumer C,Demir C,Celik MM,Celik M,Ucar E,Gunesacar R

更新日期：2013-03-01 00:00:00

abstract：:Given that vascular endothelial cells play an important role in the modulation of vascular structure and function, we hypothesized that endocardial endothelial cells (EECs) may have a modulator role in regulating the cardiac interstitial cells. Endocardial endothelial cells were isolated from freshly collected pig hea...

journal_title：Cell biochemistry and biophysics

authors： Kuruvilla L,Nair RR,Umashankar PR,Lal AV,Kartha CC

更新日期：2007-01-01 00:00:00

abstract：:Curcumin possesses anti-cancer effects. In the current study, we tested the effect of curcumin on cell proliferation, viability, apoptosis, cell cycle phases, and activation of the PI3K/Akt pathway in the renal cell carcinoma (RCC) cell line RCC-949. We observed that cell proliferation and viability were markedly inhi...

journal_title：Cell biochemistry and biophysics

authors： Zhang H,Xu W,Li B,Zhang K,Wu Y,Xu H,Wang J,Zhang J,Fan R,Wei J

更新日期：2015-12-01 00:00:00

abstract：:Synaptic glutamate receptors play a prominent role in the excitatory neurotransmission in the vertebrate central nervous system. Although elucidation of the functional properties of glutamate receptors using electrophysiologic analyses has yielded important information, methodological and technological limitations hav...

journal_title：Cell biochemistry and biophysics

authors： Vaithianathan T,Manivannan K,Kleene R,Bahr BA,Dey MP,Dityatev A,Suppiramaniam V

更新日期：2005-01-01 00:00:00

abstract：:We investigated theoretically and experimentally the Ca2+-contraction coupling in rat tracheal smooth muscle. [Ca2+]i, isometric contraction and myosin light chain (MLC) phosphorylation were measured in response to 1 mM carbachol. Theoretical modeling consisted in coupling a model of Ca2+-dependent MLC kinase (MLCK) a...

journal_title：Cell biochemistry and biophysics

authors： Mbikou P,Fajmut A,Brumen M,Roux E

更新日期：2006-01-01 00:00:00

abstract：:A number of case-control studies have been conducted to investigate the relationship between the ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms and risk of coronary heart disease (CHD). However, the results have been inconclusive. The purpose of the present study is to investigate whether this polymorp...

journal_title：Cell biochemistry and biophysics

authors： Liu N,Hou M,Ren W,Cao J,Wu H,Zhou W

更新日期：2015-01-01 00:00:00

abstract：:Semaphorin4D (Sema4D) belongs to Semaphorins family and is secreted and membrane-bound protein. Its function on angiogenesis and axon regeneration makes it an ideal therapeutic target for spinal cord injury (SCI). Here we examined Sema4D expression profile by real-time PCR and western blot and found Sema4D was upregul...

journal_title：Cell biochemistry and biophysics

authors： Zhang HL,Wang J,Tang L

更新日期：2014-04-01 00:00:00

abstract：:The study's objective was to evaluate the applicability of different endovascular methods for treatment of refractory type of Budd-Chiari syndrome (BCS) under specific scenarios frequently encountered in patients. The treatment methods were evaluated in 197 patients with the following four types of refractory BCS: les...

journal_title：Cell biochemistry and biophysics

authors： Gao Y,Chen S,Yu C

更新日期：2011-11-01 00:00:00

abstract：:Osteoclast is the only cell that can degrade bone tissue in vivo. Recent studies have shown the important role of cytoskeleton dynamics in osteolysis and the formation of podosome belt in osteoclasts. This process is regulated by the dynamic microtubule (MT) network. We treated osteoclast precursor cells Raw264.7 with...

journal_title：Cell biochemistry and biophysics

authors： Ti Y,Zhou L,Wang R,Zhao J

更新日期：2015-03-01 00:00:00

abstract：:To reveal protective role of the new Mn(II) complexes with Nicotinyl-L-Tyrosinate and Nicotinyl-L-Tryptophanate Schiff Bases against ionizing radiation. The DNA of the rats liver was isolated on 7, 14, and 30 days after X-ray irradiation. The differences between the DNA of irradiated rats and rats pre-treated with Mn(...

journal_title：Cell biochemistry and biophysics

authors： Karapetyan NH,Malakyan MH,Bajinyan SA,Torosyan AL,Grigoryan IE,Haroutiunian SG

更新日期：2013-01-01 00:00:00

abstract：:The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. The homology models of the ligand binding domains of the human umami receptor have been constructed based on crystallographic structures of the taste receptor of the central nervous system. Furthermore, t...

journal_title：Cell biochemistry and biophysics

authors： Dang Y,Gao X,Xie A,Wu X,Ma F

更新日期：2014-12-01 00:00:00

abstract：:The calcium channel gamma subunits comprise an eight-member protein family that share a common topology consisting of four transmembrane domains and intracellular N- and C-termini. Although the first gamma subunit was identified as an auxiliary subunit of a voltage-dependent calcium channel, a review of phylogenetic, ...

journal_title：Cell biochemistry and biophysics

authors： Chen RS,Deng TC,Garcia T,Sellers ZM,Best PM

更新日期：2007-01-01 00:00:00

abstract：:Recent studies have shown that endothelial progenitor cells (EPCs) participated in angiogenic effects of nicotine and nicotine dose dependently increased the functional activity of early EPCs. The effects of nicotine on late EPCs remain to be determined. Therefore, we investigated whether nicotine had influences on th...

journal_title：Cell biochemistry and biophysics

authors： Yu M,Li Z,Shu Z,Liu Q,Sun J,Tan X

更新日期：2014-11-01 00:00:00

abstract：:The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-beta subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-beta, specific and high-affinity binding to cell membrane serine/threonine ...

journal_title：Cell biochemistry and biophysics

authors： Camoretti-Mercado B,Solway J

更新日期：2005-01-01 00:00:00

abstract：:The bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is formed as a byproduct of visual cycle in retinal pigment epithelium (RPE). It contributes to golden-yellow fluorescence of the age pigment lipofuscin, which accumulates in RPE. Lipofuscin can generate a variety of reactive oxygen species (ROS) upon blue-l...

journal_title：Cell biochemistry and biophysics

authors： Furso J,Zadlo A,Szewczyk G,Sarna TJ

更新日期：2020-12-01 00:00:00

abstract：:Cotton bollworm, Helicoverpa armigera, is one of the most damaging polyphagous pests worldwide, which has developed high levels of resistance to commonly applied insecticides. Mitochondrial P-glycoprotein (Pgp) was detected in the insecticide-resistant strain of H. armigera using C219 antibodies, and its possible role...

journal_title：Cell biochemistry and biophysics

authors： Akbar SM,Aurade RM,Sharma HC,Sreeramulu K

更新日期：2014-09-01 00:00:00

abstract：:Currently, autologous bone marrow-derived stem cell is one of the most innovative areas of stem cells research. Previous studies on animal models of nervous system diseases have shown that these cells have a good effect on nervous system disorders. The alternative treatment with stem cells for the nervous system disea...

journal_title：Cell biochemistry and biophysics

authors： Ren C,Geng RL,Ge W,Liu XY,Chen H,Wan MR,Geng DQ

更新日期：2014-05-01 00:00:00

abstract：:A rapid and sensitive liquid chromatography-tandem mass spectrometry assay (LC-MS/MS) with electrospray ionization was developed and validated for the quantitative determination of the concentration of methotrexate (MTX) enantiomers in intracellular and extracellular fluids of HepG2 cells. The analytes were extracted ...

journal_title：Cell biochemistry and biophysics

authors： Wang R,Guo L,Xie H,Zhang J,Li X,Li W,Wang J,Wu X,Jia Z

更新日期：2013-01-01 00:00:00

abstract：:The aim of the study was to evaluate the clinical efficacy of hydrogen sulfide (H2S) treatment on the endothelin-induced cardiac hypertrophy. Sixty-four adult male rats, weighing from 180 to 200 g, were randomly divided into four groups: ten in normal group, ten in sham group, 44 in model group established by inducing...

journal_title：Cell biochemistry and biophysics

authors： Yang F,Liu Z,Wang Y,Li Z,Yu H,Wang Q

更新日期：2014-12-01 00:00:00

abstract：:Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is a cellular receptor for hepatitis C virus for the binding of viral envelope glycoprotein E2. Interaction of DC-SIGN with the E2 may evoke cellular signal transduction implicated in viral pathogenesis. We developed a cell model ...

journal_title：Cell biochemistry and biophysics

authors： Chen QL,Zhu SY,Bian ZQ,Zhao LJ,Cao J,Pan W,Qi ZT

更新日期：2010-01-01 00:00:00

abstract：:Objective of this article is to construct and characterize a three-layered small-caliber, artificial vascular stent. The outer layer of the stent consisted of small intestine submucosa (SIS), the middle layer was the polydioxanone (PDS) vascular stents, and the inner layer. The SIS and PDS were attached with 8-0 PDS t...

journal_title：Cell biochemistry and biophysics

authors： You Q,Wang F,Duan L,Du X,Xiao M,Shen Z

更新日期：2010-05-01 00:00:00

abstract：:In this study, the anti-proliferative effect of physcion, an anthraquinone derivative isolated and characterized from both terrestrial and marine sources, against human gastric cancer SGC-7901 cells was investigated and the underlying mechanisms were explored. Physcion reduced SGC-7901 cell viability in a dose- and ti...

journal_title：Cell biochemistry and biophysics

authors： Xiong Y,Ren L,Wang Z,Hu Z,Zhou Y

更新日期：2015-11-01 00:00:00

abstract：:Red blood cell (RBC) adhesion to vessel wall endothelium is a potent catalyst of vascular occlusion and occurs in oxidative stress states such as hemoglobinopathies and cardiovascular conditions. These are often treated with vitamin E (VitE), a "classic" antioxidant. In this study, we examined the effects of VitE on R...

journal_title：Cell biochemistry and biophysics

authors： Koshkaryev A,Barshtein G,Yedgar S

更新日期：2010-04-01 00:00:00

abstract：:Molecular motors are responsible of transporting a wide variety of cargos in the cytoplasm. Current efforts are oriented to characterize the biophysical properties of motors in cells with the aim of elucidating the mechanisms of these nanomachines in the complex cellular environment. In this study, we present an algor...

journal_title：Cell biochemistry and biophysics

authors： Bruno A,Bruno L,Levi V

更新日期：2013-01-01 00:00:00