Anticancer chemosensitivity profile of freshly separated human pancreatic cancer cells assessed by DNA synthesis inhibition assay.

Abstract:

:The chemosensitivity of 49 freshly separated human pancreatic cancers to seven kinds of anticancer agents were assessed by a DNA synthesis (3H-thymidine incorporation) inhibition assay. DNA synthesis is higher in involved lymph nodes (n = 7), malignant effusion (n = 15), liver metastasis (n = 7), primary cancer (n = 15), and skin metastasis (n = 5). Chemosensitivity assay demonstrates that etoposide, 4-epirubicin, carboquone, and 5-fluorouracil are more effective than cisplatin, mitomycin-C, and Adriamycin. In general, metastatic lesions of pancreatic cancer tend to show higher chemosensitivity than primary lesions. Pathological analysis demonstrates that small primary pancreatic cancers tend to be more responsive than large primary cancers, and primary pancreatic cancers with no regional lymph node involvement also tend to be more responsive than those with nodal involvement. No significant differences are seen in terms of tumor spread, vascular involvement, sex of patient, and histological type. When chemosensitivity assay is not available, the results of the present study may be beneficial to choose the regimens.

journal_name

J Surg Oncol

authors

Masai Y,Nio Y,Tsubono M,Tseng CC,Kawabata K,Hayashi H,Ishigami S,Imamura M

doi

10.1002/jso.2930570206

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

97-104

issue

2

eissn

0022-4790

issn

1096-9098

journal_volume

57

pub_type

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