Abstract:
:Studies on the association between genetic polymorphisms and personality disorders have provided inconsistent results. Using the "enriched sample method," the authors of the present study aimed to assess the association between polymorphisms in the serotonergic transmitter system and comorbid personality disorders in patients recently diagnosed with first-episode depression. A total of 290 participants were systematically recruited via the Danish Psychiatric Central Research Register. Diagnoses of personality disorders were assessed by a SCID-II interview, and polymorphisms in the genes encoding the serotonin transporter, serotonin receptors 1A, 2A, 2C, and tryptophan hydroxylase 1 were genotyped. The authors found a significant effect of the length polymorphism in the serotonin transporter gene (5-HTTLPR) on cluster B personality disorder (mainly borderline disorder), but no influence on cluster C personality disorder, and no associations between other polymorphisms and personality disorders. The study adds evidence to the effect of the serotonin transporter gene specifically on cluster B personality disorders.
journal_name
J Pers Disordjournal_title
Journal of personality disordersauthors
Bukh JD,Bock C,Kessing LVdoi
10.1521/pedi_2013_27_123subject
Has Abstractpub_date
2014-06-01 00:00:00pages
365-78issue
3eissn
0885-579Xissn
1943-2763journal_volume
28pub_type
杂志文章abstract::This study evaluates personality disorder as a moderator of psychiatric treatment response in people receiving methadone-assisted treatment. Participants (N = 125) were enrolled in a 12-week parent study that evaluated the impact of incentives on attendance to psychiatric care. All participants had a current DSM IV-R ...
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journal_title:Journal of personality disorders
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journal_title:Journal of personality disorders
pub_type: 杂志文章,评审
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