Abstract：
PURPOSE:To provide evidence-based recommendations for diabetic macular edema (DME) management based on updated information from publications on DME treatment modalities. DESIGN:Perspective. METHODS:A literature search for "diabetic macular edema" or "diabetic maculopathy" was performed using the PubMed, Cochrane Library, and ClinicalTrials.gov databases to identify studies from January 1, 1985 to July 31, 2013. Meta-analyses, systematic reviews, and randomized controlled trials with at least 1 year of follow-up published in the past 5 years were preferred sources. RESULTS:Although laser photocoagulation has been the standard treatment for DME for nearly 3 decades, there is increasing evidence that superior outcomes can be achieved with anti-vascular endothelial growth factor (anti-VEGF) therapy. Data providing the most robust evidence from large phase II and phase III clinical trials for ranibizumab demonstrated visual improvement and favorable safety profile for up to 3 years. Average best-corrected visual acuity change from baseline ranged from 6.1-10.6 Early Treatment Diabetic Retinopathy Study (ETDRS) letters for ranibizumab, compared to 1.4-5.9 ETDRS letters with laser. The proportion of patients gaining ≥ 10 or ≥ 15 letters with ranibizumab was at least 2 times higher than that of patients treated with laser. Patients were also more likely to experience visual loss with laser than with ranibizumab treatment. Ranibizumab was generally well tolerated in all studies. Studies for bevacizumab, aflibercept, and pegaptanib in DME were limited but also in favor of anti-VEGF therapy over laser. CONCLUSIONS:Anti-VEGF therapy is superior to laser photocoagulation for treatment of moderate to severe visual impairment caused by DME.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Mitchell P,Wong TY,Diabetic Macular Edema Treatment Guideline Working Group.doi
10.1016/j.ajo.2013.11.012subject
Has Abstractpub_date
2014-03-01 00:00:00pages
505-13.e1-8issue
3eissn
0002-9394issn
1879-1891pii
S0002-9394(13)00735-6journal_volume
157pub_type
杂志文章,实务指引abstract：PURPOSE:To evaluate whether retinal vessel abnormalities are associated with early or late age-related macular degeneration (AMD) in adult Chinese. DESIGN:Population-based prevalence study. METHODS:The Beijing Eye Study included 4439 (83.4%) subjects of 5324 living in a rural area or urban region of Greater Beijing, ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.05.028
更新日期：2006-10-01 00:00:00
abstract：PURPOSE:To measure peripapillary retinal nerve fiber layer volume in normal subjects and patients with ocular hypertension, primary open-angle glaucoma, and low-tension glaucoma. METHODS:Sixty-five subjects were classified into four groups of normal subjects and subjects with ocular hypertension, primary open-angle gl...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00464-x
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:To investigate the clinical and electrophysiologic natural history of Stargardt disease and correlate with the genotype. DESIGN:Cohort study of 59 patients. METHODS:Clinical history, examination, and electrophysiologic assessment were undertaken in a longitudinal survey. Patients were classified into 3 groups...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2013.01.018
更新日期：2013-06-01 00:00:00
abstract：:Ultrashort, Q-switched or mode-locked, neodymium-YAG laser pulses focused within 2 mm of the retina caused reproducible retinal damage in four eyes of two monkeys and in four eyes of three rabbits. The distance of the laser focus from the retina for clinically observed threshold retinal damage was characterized for pu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)77782-7
更新日期：1983-08-01 00:00:00
abstract：PURPOSE:To determine whether glaucoma patients exhibit an abnormal melatonin concentration in aqueous humor. DESIGN:Case-controlled study, laboratory investigation. METHODS:Aqueous humor and plasma samples of 28 patients with primary open-angle glaucoma and 31 nonglaucoma control patients were collected during surger...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.03.040
更新日期：2006-08-01 00:00:00
abstract：:In seven eyes of six patients (four men and two women, 55 to 72 years old), with macular edema associated with severe carotid artery stenosis, the ipsilateral carotid obstruction was 90% or more. Concomitant fundus signs, such as midperipheral retinal hemorrhages, retinal arterial narrowing, and neovascularization of ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90071-1
更新日期：1986-10-15 00:00:00
abstract：PURPOSE:To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed. DESIGN:Prospective, interventional trial. METHODS:Study subjects comprised all consecutive patients with noninfectious posterior uveitis who ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.11.008
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To report clinicopathologic features, radiologic findings, and treatment outcomes of isolated, orbital aspergillosis. DESIGN:Multicenter, retrospective case series. METHODS:setting: Multicenter. PARTICIPANTS:There were 8 lesions in 8 eyes of 8 patients with isolated, orbital aspergillosis. PROCEDURE:Revie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajo.2016.03.007
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:To determine iridocorneal angle changes produced after 2 years of implantable collamer lens (ICL) V4c (STAAR Surgical AG, Nidau, Switzerland) placement by Fourier-domain optical coherence tomography (FD-OCT). DESIGN:Prospective interventional case series. METHODS:In 54 eyes of 27 myopic subjects FD-OCT iridoc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.06.018
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2016.09.017
更新日期：2016-12-01 00:00:00
abstract：:Of 30 consecutive patients with ocular adnexal basal cell carcinoma, 18 (60%) had at least one additional unsuspected foci of basal cell carcinoma. The patients most likely to have additional basal cell skin cancer were women, those with previous basal cell carcinoma, and those whose eyelid lesions were recurrent, loc...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90002-2
更新日期：1982-11-01 00:00:00
abstract：PURPOSE:In juvenile X-linked retinoschisis (XLRS), fluorescein angiography is usually unremarkable and contributes poorly to the diagnosis. However, indocyanine green (ICG) angiography features in eyes that are affected with XLRS were not yet described. DESIGN:Retrospective observational case series. METHODS:A comple...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.03.051
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To report a case of unilateral proptosis and chronic pansinusitis in which the diagnosis of pneumocele was made. DESIGN:Observational case report. METHODS:A retrospective chart review was made. RESULTS:A 52-year-old man with chronic pansinusitis presented with a 5-mm proptosis and a larger palpebral fissure ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.02.054
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To describe a case of exudative retinal capillary hemangioma treated with photodynamic therapy that resulted in an improvement in clinical appearance and visual acuity. DESIGN:Interventional case report. METHODS:A 55-year-old Asian man presented with a large exudative peripheral retinal capillary hemangioma o...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(02)01648-3
更新日期：2002-11-01 00:00:00
abstract：PURPOSE:To determine the safety and efficacy of verteporfin photodynamic therapy (PDT) for the treatment of persistent choroidal neovascularization (CNV) previously treated with external beam radiotherapy (EBRT). DESIGN:Retrospective case series. METHODS:Verteporfin PDT was performed on 14 eyes of 13 patients with sy...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2004.09.019
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:To define the epidemiology of severe ocular trauma in Singapore. METHODS:A population-based incidence study involving all Singapore citizens and residents. Two government-administered databases were used to capture information on severe ocular trauma in Singapore. The national hospital discharge database provi...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00167-1
更新日期：1999-09-01 00:00:00
abstract：:d-Isoproterenol (ISO) applied topically to the rabbit eye specifically lowered intraocular pressure. Thus, it effectively reduced normal intraocular pressure and inhibited intraocular pressure elevation induced by water load without causing other obvious local or systemic pharmacologic effects. By comparison, dl-ISO w...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90688-1
更新日期：1975-06-01 00:00:00
abstract：:Normal volunteers used 1, 2, and 4% pilocarpine eyedrops, three times daily, or ocular therapeutic systems placed in the conjunctival cul-de-sac to control intraocular pressure. The systems continuously release 20 and 40 mug/hour of pilocarpine for one week. Although the amount of drug delivered to the eye from the o...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9394(75)90404-3
更新日期：1975-10-01 00:00:00
abstract：:Eight patients with manifest latent nystagmus, as noted by ocular movement recordings, were examined for nystagmus reduction after surgical or optical treatment. Seven of the patients had strabismus. Five patients underwent strabismus surgery, had no tropia postoperatively, and the manifest latent nystagmus converted ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76985-5
更新日期：1990-08-15 00:00:00
abstract：:Benign lateral rectus palsy developed in two adults, a 62-year-old man and a 56-year-old woman. Both were hospitalized because of headache and diplopia. Extensive laboratory and neurologic testing showed no abnormalities except leukopenia (the white blood cell count was 2,600 cells/mm3 in one patient and 3,100 cells/m...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90254-9
更新日期：1982-10-01 00:00:00
abstract：PURPOSE:To report the incidence and risk factors of elevated IOP following deep anterior lamellar keratoplasty (DALK). DESIGN:A retrospective case series. METHODS:A retrospective study investigating the 5-year incidence of raised IOP following DALK cases performed from 2004 to 2008 in a tertiary center. Patients with...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2016.07.025
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:To investigate the relationship of circulating levels of soluble form of LR11 (sLR11; also called SorLA or SORL1), with the progression of proliferative diabetic retinopathy (PDR) in patients with type 2 diabetes mellitus. DESIGN:Cross-sectional study. METHODS:Fifty-four patients with type 2 diabetes mellitus...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.01.035
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:To investigate the retention rate and complications of 2 different types of silicon lacrimal punctal plugs with the focus on the relationship to punctum size. DESIGN:A prospective, nonrandomized, interventional, comparative study. METHOD:Forty-four patients with dry eye syndrome received lacrimal punctal plug...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2012.10.024
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To document and study the relationship between perimetric sensitivity and retinal thickness at the foveal and parafoveal points in eyes with macular edema associated with branch retinal vein occlusion. METHODS:A prospective study was performed using the central 10-2 Humphrey perimetry program and optical coher...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00722-4
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis. DESIGN:Case-control study. METHODS:Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.05.015
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:To report the prevalence rates of anisometropia in a school population and determine the relative contribution of refractive power and axial length to the measured anisometropia. DESIGN:Population-based cross-sectional study. METHODS:Autorefraction, keratometry, and ultrasonography studies were made. SETTING...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2003.10.028
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:This study sought to compare the postoperative visual outcomes of toric implantable collamer lens (T-ICL) with toric Artiflex (T-Artiflex) lenses. DESIGN:Alternating treatment, contralateral eye matched clinical study. METHODS:This study compared 82 eyes of 41 patients with T-ICL lenses in one eye and toric A...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.06.021
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To study the association between peripheral changes in age-related macular degeneration (AMD) and dark adaptation (DA). DESIGN:Prospective, cross-sectional study. METHODS:We recruited patients with AMD and a control group (>50 years) without any vitreoretinal disease. Ultra-widefield (UWF) pseudocolor and fun...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2018.03.035
更新日期：2018-06-01 00:00:00
abstract：:Two siblings had atrophic maculopathy associated with hereditary ataxia clinically defined as an olivopontocerebellar degeneration. The macular changes were suggestive of an early bull's-eye maculopathy in one case and of a late atrophic stage of bull's-eye maculopathy in the other. This suggests that concentric annul...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75125-6
更新日期：1980-11-01 00:00:00
abstract：PURPOSE:To describe rifabutin-associated uveitis with opacities in the inferior and posterior vitreous in three patients with acquired immunodeficiency syndrome. METHOD:Case reports of the three patients are presented. RESULTS:The patients, who were being treated with rifabutin and fluconazole, developed anterior and...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)72124-5
更新日期：1996-10-01 00:00:00
