Abstract:
:The American Academy of Pediatrics (AAP) recommends that any child diagnosed with hypertension have an echocardiogram to evaluate for the presence of left-ventricular (LV) hypertrophy (LVH) and advocates that LVH is an indication to initiate or intensify antihypertensive therapy. However, there is no consensus on the ideal method of defining LVH in the pediatric population. Many pediatric cardiologists rely on wall-thickness z-score of the LV posterior wall and/or interventricular septum to determine LVH. Yet, the AAP advocates using LV mass indexed to 2.7 (LVMI(2.7)) ≥ 51 g/m(2.7) to diagnose LVH. Recently, age-specific reference values for LVMI ≥ 95% were developed. The objective of the study was to determine the concordance between diagnosis of LVH by wall-thickness z-score and diagnosis by LVMI(2.7) criteria. A retrospective chart review was performed for subjects diagnosed with hypertension at a single tertiary care center (2009-2012). Echocardiogram reports were reviewed, and assessment of LVH was recorded. Diagnosis of LVH was assigned to each report reviewed according to three criteria: (1) LV wall-thickness z-score > 2.00; (2) age-specific reference values for LVMI(2.7) > 95th percentile; and (3) LVMI(2.7) > 51 g/m(2.7). Cohen's kappa statistic was used as a measurement of agreement between diagnosis by wall-thickness z-score and diagnosis using LVMI(2.7). A total of 159 echocardiograms in 109 subjects were reviewed. Subjects included 31 females and 77 males, age 13.2 ± 4.4 years, and 39 (42%) with a diagnosis of secondary hypertension. LVH was diagnosed in 31 cases (20%) based on increased wall-thickness z-score. Using LVMI(2.7) > 95%, LVH was found in 75 (47%) cases (mean LVMI(2.7)42.3 ± 17.2 g/m(2.7) [range 11.0-111 g/m(2.7)]). The wall-thickness z-score method agreed with LVMI(2.7) > 95% diagnosis 71% of the time (kappa 0.4). Using LVH criteria of LVMI(2.7) ≥ 51 g/m(2.7), 33 (21%) subjects were diagnosed with LVH. There was 79% agreement in the diagnosis of LVH between the wall-thickness z-score method and LVMI(2.7) > 51 g/m(2.7) (kappa 0.37). There is poor concordance between the diagnosis of LVH on echocardiogram reports using wall-thickness z-score and diagnosis of LVH using LVMI(2.7) criteria. It is important to establish a consensus method for diagnosing LVH because of the high frequency of cardiovascular complications in children with hypertension.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Mirchandani D,Bhatia J,Leisman D,Kwon EN,Cooper R,Chorny N,Frank R,Infante L,Sethna Cdoi
10.1007/s00246-013-0829-7subject
Has Abstractpub_date
2014-04-01 00:00:00pages
622-6issue
4eissn
0172-0643issn
1432-1971journal_volume
35pub_type
杂志文章abstract::Combination of right and left ventricular outflow tracts obstruction is extremely rare. Neonates with combined aortic stenosis (AS) and pulmonary stenosis (PS) present in critical condition and required urgent treatment. The management approach is not well defined. We report five female neonates with combined AS and P...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-1000-9
更新日期:2014-12-01 00:00:00
abstract::Intramural coronary artery is known to be a risk factor for early death after an arterial switch operation (ASO). We evaluated the early and mid-term results of ASO for patients with intramural coronary artery. From September 2008 to March 2012, seven patients with an intramural coronary artery underwent ASO at our ho...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0968-5
更新日期:2015-01-01 00:00:00
abstract::Our purpose was to evaluate the impact of suspicion or confirmation of heart disease on the physical and psychosocial health of children. We utilized the Child Health Questionnaire (CHQ PF-50). Children ages 5 to 18 years attending a general cardiology clinic were eligible. Those with primary noncardiac diagnoses unre...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0348-z
更新日期:2004-01-01 00:00:00
abstract::Aortopulmonary window coexisting with tetralogy of Fallot (TF) was prospectively diagnosed by two-dimensional (2D) echocardiography and Doppler in an 18-month-old boy; the diagnosis was confirmed by cardiac catheterization and angiocardiography. Surgical correction was performed, but the patient died in the operating ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02239546
更新日期:1990-01-01 00:00:00
abstract::We describe two cases of left-side pulmonary vein obstruction observed after the arterial switch operation (Jatene) for D-transposition of the great arteries. This appears to be related to left-sided pulmonary vein obstruction occurring coincidently with D-transposition of the great arteries, rather than a consequence...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900180
更新日期:1997-07-01 00:00:00
abstract::We undertook a study to identify the hemodynamic significance of a Doppler-derived gradient across a stenotic pulmonary valve. Furthermore, we attempted to define the optimal plane for velocity data acquisition. A total of 17 children with valvar pulmonary stenosis were evaluated using Doppler echocardiography. Flow-v...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02081678
更新日期:1989-07-01 00:00:00
abstract::The aim of this study was to evaluate by Doppler echocardiography whether administration of transdermal nitroglycerin (NTG) to children with congestive heart failure could modify mitral flow velocity profile with redistribution of left ventricular filling to late diastole, suggesting preload reduction of the left vent...
journal_title:Pediatric cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002460010144
更新日期:2001-01-01 00:00:00
abstract::Cardiac involvement of Duchenne and Becker muscular dystrophies (DMD/BMD) is the most common cause of fatal outcomes. It is still unclear whether some DMD/BMD gene mutations might be predictive of cardiac involvement. In this study, we provide a comprehensive overview on genotypes of cardiac disease in DMD/BMD. We sys...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02470-4
更新日期:2020-10-09 00:00:00
abstract::Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C, PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of small GTPase RhoA. Rho-kinase is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, and proli...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-011-9920-0
更新日期:2011-03-01 00:00:00
abstract::Device closure of atrial septal defects (ASDs) is rapidly becoming routine in children. Comparisons are often made to older surgical series with higher morbidities. However outcomes including reintervention, late failure, and the need for long-term follow-up must be considered and compared to those of a current surgic...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-002-0131-6
更新日期:2003-09-01 00:00:00
abstract::Isolation of the left innominate artery arising from the ductus arteriosus is a rare clinical entity with only nine cases being reported in the literature [5, 7, 8]. We describe a case consisting of tetralogy of Fallot, right aortic arch, and isolation of the left innominate artery arising from a left-sided ductus art...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010154
更新日期:2001-01-01 00:00:00
abstract::In August 2010, the Nit-Occlud® Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud® Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 E...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-016-1502-8
更新日期:2017-02-01 00:00:00
abstract::Percutaneous balloon aortic valvuloplasty was attempted in an eight-month-old infant with severe aortic valve stenosis. The procedure resulted in a fall in the resting transvalvular systolic pressure gradient from 106 mmHg to 40 mmHg and no aortic regurgitation. Clinical and Doppler echocardiography findings suggest p...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02282747
更新日期:1985-01-01 00:00:00
abstract::Balloon angioplasty for native coarctation of the aorta in infants and children is gaining acceptance as an alternative to surgery in discrete membranous obstruction. The aim of this study was to assess the immediate and intermediate-term effectiveness and safety of balloon angioplasty in infants and children with dis...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9029-7
更新日期:2008-05-01 00:00:00
abstract::We report on a 4-kg infant with Alagille syndrome and congenital heart disease consisting of atrial septal defect (ASD), patent ductus arteriosus (PDA), and severe peripheral pulmonic stenosis. He underwent successful orthotopic liver transplant along with catheter closure of the ASD and PDA using the Amplatzer device...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms a...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1245-y
更新日期:2016-01-01 00:00:00
abstract::Horseshoe lung is a rare malformation that is often associated with lung hypoplasia and/or vascular anomalies. We describe a 10-year-old girl with horseshoe lung and unique left pulmonary vein. This is the first reported case with this vascular feature. The patient presented with signs and symptoms of severe pulmonary...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9735-4
更新日期:2010-08-01 00:00:00
abstract::Two cases of arrhythmogenic right ventricular dysplasia (ARVD) in siblings are reported. In the boy, 14 years old, the clinical history, ECG, echocardiography, and histopathological findings were consistent with ARVD. Premature ventricular contractions of left bundle branch block (LBBB) pattern were recorded but no ve...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02239576
更新日期:1990-04-01 00:00:00
abstract::The original version of the article unfortunately contained an alignment error in Table 1. The correct version of Table 1 is given below. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00246-018-1978-5
更新日期:2019-01-01 00:00:00
abstract::Internationally, there have been isolated case reports published of children presenting with dilated cardiomyopathy (DCM) in the setting of undiagnosed rickets. Although there has been an increased prevalence of rickets in the United States, there has been only one documented case of associated DCM. At our institution...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9444-z
更新日期:2009-08-01 00:00:00
abstract::Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare condition. The majority of cases present with impaired left ventricular function. We report on a premature infant who was diagnosed at a gestational age near term with ALCAPA during routine cardiac examination. The patient showed...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0878-z
更新日期:2006-03-01 00:00:00
abstract::The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shu...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0462-x
更新日期:2013-02-01 00:00:00
abstract::This study aimed to assess the technical aspects of atrial septal defect (ASD) closure using the Amplatzer septal occluder (ASO) and the Gore Helex septal occluder (GHSO) for infants weighing less than 8 kg and to determine the safety, effectiveness, and near-to-intermediate-term outcome of the closure. The Mid-Atlant...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-014-0905-7
更新日期:2014-10-01 00:00:00
abstract::This report describes the case of a 29-day-old infant with Kawasaki's disease who presented in extremis with multiple coronary aneurysms and coronary thromboses, myocardial ischemia, and congestive heart failure. The infant successfully underwent emergent coronary thrombolysis with tissue plasminogen activator. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9781-y
更新日期:2010-11-01 00:00:00
abstract::We describe the first report of an infant who was born with hypoplastic left heart syndrome and significant pulmonary stenosis. He was successfully palliated with multiple cardiac catheterization interventions while waiting for cardiac transplantation. This unusual constellation of heart defects is an entity that is r...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0856-5
更新日期:2005-09-01 00:00:00
abstract::Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, obser...
journal_title:Pediatric cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00246-019-02215-y
更新日期:2019-12-01 00:00:00
abstract::Controversy exists as to whether a hemodynamically significant left-to-right shunt due to a patent ductus arteriosus (PDA) affects ventricular contractility. Load-dependent indices such as ejection fraction and shortening fraction have traditionally been used to assess contractility, but the relationship between the r...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0452-0
更新日期:2004-03-01 00:00:00
abstract::In a patient with single ventricle, mitral atresia, common atrium, pulmonary stenosis, azygos continuation of the inferior vena cava and bilateral systemic artery--pulmonary artery anastomoses, the systemic veins were connected directly to the pulmonary arteries to achieve physiologic repair; the child was discharged ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart function rather than regenerate lost myocardium. A major hurdle in implementing a cell-based regenerative therapy is the in...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9409-2
更新日期:2009-07-01 00:00:00
abstract::Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-2005-6
更新日期:2019-01-01 00:00:00