Abstract：
:The aim of this study was to evaluate by Doppler echocardiography whether administration of transdermal nitroglycerin (NTG) to children with congestive heart failure could modify mitral flow velocity profile with redistribution of left ventricular filling to late diastole, suggesting preload reduction of the left ventricle. Twelve children with congestive heart failure, aged from 6 months to 6 years (2.83 +/- 2.24 years; mean +/- SD), were recruited. Patients were randomly allocated either a NTG patch (study group; n = 6) or a placebo patch (control group; n = 6) in a double-blind procedure. The NTG patch was a 10-cm(2) patch releasing 5 mg of NTG per day. NTG patches were adjusted to a dose of 1 cm(2)/kg/day (0.5 mg/kg/day). Peak velocity and time--velocity integral (TVI) of E and A waves of transmitral flow, the ratio of the velocities of the A wave and E wave, and the ratio of the TVI of the A wave to the TVI of the E wave were measured. Doppler measurements were determined before treatment (H0) and 4 hours (H4) and 23 hours (H23) after the patch application. Relative changes of these parameters were not significantly different between these two groups. In the NTG group, mean NTG plasma concentration was 1.08 +/- 0.47 microg Liter(-1) at H4 (n = 5) and 1.18 +/- 0.81 microg Liter(-1) at H23 (n = 5). No patient had a NTG plasma concentration greater than 2 microg Liter(-1) either at H3 or at H24. These data suggest that 1 cm(2)/kg transdermal doses of NTG may have a limited bioavailability or a higher clearance and minimal hemodynamic effects in children with congestive heart failure already receiving other medications, implying that higher doses should be used.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Vaksmann G,Pariente-Khayat A,Godart F,Francart C,Rey E,D'Athis P,Pons G,Rey Cdoi
10.1007/s002460010144subject
Has Abstractpub_date
2001-01-01 00:00:00pages
11-3issue
1eissn
0172-0643issn
1432-1971pii
10.1007/s002460010144journal_volume
22pub_type
临床试验,杂志文章,随机对照试验abstract：:The epinephrine test has been shown to be a powerful tool to predict the genotype of congenital long QT syndrome (LQTS). The aim of this study was to evaluate its role in the diagnosis and management of LQTS in children. The test (using the Shimizu protocol) was conducted in patients with some evidence of LQTS but in ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-009-9603-2
更新日期：2010-05-01 00:00:00
abstract：:Subtotal cor triatriatum sinister (partially divided left atrium) is characterized by a membrane dividing the left atrium into two portions: a dorsal accessory proximal chamber that receives part of the pulmonary venous return and a small restrictive defect in the membrane that obstructs blood flow from the accessory ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9205-4
更新日期：2008-07-01 00:00:00
abstract：:Contrary to acquired arteriovenous fistulas, the congenital malformations are very rare. Here we report a case of congenital arteriovenous fistula forming a communication between the right subclavian artery to subclavian vein. To our knowledge, there is no similar case in which an infant has been successfully operated...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010056
更新日期：2000-05-01 00:00:00
abstract：:Congenital diverticulum of the left ventricle, a rare malformation, is usually associated with midline thoracoabdominal defect. We describe a case with congenital left ventricular diverticulum presenting as an isolated lesion. The lesion was suspected on two-dimensional echocardiography and was confirmed by cardiac ca...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02524804
更新日期：1996-07-01 00:00:00
abstract：:In this report, we describe a case of coarctation of the aorta, congenital aortic stenosis with bicuspid valve, and supravalvar aortic stenosis with left coronary artery ostial stenosis. The child underwent staged treatment using a hybrid approach employing both surgical and interventional cardiology methods. A single...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010164
更新日期：2001-01-01 00:00:00
abstract：:To determine whether diastolic ventricular interdependence mechanisms would act in the presence of an open pericardial sac, as during cardiac surgery, moderate acute right ventricle afterload increases were applied to eight dogs with the chest and pericardium open while left ventricular filling dynamics were being ass...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02505087
更新日期：1996-03-01 00:00:00
abstract：:Interruption of the aortic arch and hypoplastic left heart syndrome in the same patient is exceptional. In the combined collections of the Registry of Cardiovascular Disease (St. Paul, Minnesota, U.S.A.) and the Registry of Congenital Heart Defects of the Rijksuniversiteit Gent (Gent, Belgium) three specimens were fou...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00798068
更新日期：1995-11-01 00:00:00
abstract：:The single right ventricle (RV) in hypoplastic left heart syndrome (HLHS) often develops systolic dysfunction with time and this affects prognosis. Mechanical dyssynchrony has been reported in HLHS but has not consistently correlated with systolic function or electrical dyssynchrony. The aims of this study were to ass...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02091-6
更新日期：2019-06-01 00:00:00
abstract：:We report a case of a 12-year-old boy with severe congenital aortic stenosis in whom magnetic resonance imaging (MRI) with delayed contrast enhancement demonstrated extensive subendocardial hyperenhancement within the left ventricle. The hyperenhancement was confirmed to be subendocardial infarct and fibrosis by histo...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-5891-3
更新日期：2006-05-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIG) administered in the acute stage of Kawasaki disease (KD) is the standard therapy. Few reports describe nonresponders to initial treatment with IVIG in KD, which remains the most consistent risk factor for coronary artery lesions (CALs). This study aimed to investigate whether the seru...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0724-2
更新日期：2013-01-01 00:00:00
abstract：:Color-coded two-dimensional (2D) echocardiography confirmed the presence of severe congenital mitral regurgitation in an 8-month-old infant. Intraoperative inspection revealed an isolated perforation in the anterior leaflet. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02239570
更新日期：1990-04-01 00:00:00
abstract：:The authors hypothesized that prospective, systematic Internet searches could identify occurrences of sudden cardiac death (SCD) in athletes and would be useful for establishing a system of active surveillance. Weekly advanced Google searches of the Internet were conducted for cases of SCD in young athletes during a 1...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0717-1
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The optimal surgical strategy for pulmonary atresia with ventricular septal defect (PA/VSD) in neonates and young infants is controversial. Staged repair may be associated with a higher risk of inter-stage mortality, while primary repair may lead to frequent post-repair re-interventions. METHODS:From 2004 t...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02352-9
更新日期：2020-06-01 00:00:00
abstract：:Branch pulmonary artery stenosis (BPAS) in the setting of systemic-pulmonary artery shunts (SPS) may result in significant sequelae. Limited information exists regarding the safety and efficacy of pulmonary artery balloon angioplasty and stent implantation via SPS in neonates and infants. This study aimed to examine t...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0657-9
更新日期：2013-08-01 00:00:00
abstract：:Cardiopulmonary bypass (CPB) reduces coagulation factor levels through hemodilution and consumption. Differences in CPB-induced alterations of factor XIII (FXIII) levels in children with cyanotic and acyanotic congenital heart defects (CHDs) are not well characterized. FXIII activity (determined by Berichrom assay), p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0903-9
更新日期：2014-10-01 00:00:00
abstract：:A blood pump specifically designed to augment flow from the great veins through the lungs would ameliorate the poor physiology of the failing univentricular circulation and result in a paradigm shift in the treatment strategy for Fontan patients. This study is the first to examine mechanical cavopulmonary assistance w...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0649-9
更新日期：2013-08-01 00:00:00
abstract：:This case report describes a boy who had Kawasaki disease (KD) at age 12 months and had a recurrence one year later. The coronary arteries were normal following the initial episode; however, during the second episode he developed coronary aneurysms. Gallium-67 radionuclide imaging, echocardiography, and angiography we...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310998
更新日期：1986-01-01 00:00:00
abstract：:Device closure of atrial septal defects (ASDs) is rapidly becoming routine in children. Comparisons are often made to older surgical series with higher morbidities. However outcomes including reintervention, late failure, and the need for long-term follow-up must be considered and compared to those of a current surgic...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-002-0131-6
更新日期：2003-09-01 00:00:00
abstract：:The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02513-w
更新日期：2021-01-04 00:00:00
abstract：:Recurrent congenital left atrial aneurysm presenting in a newborn as cardiac tamponade is described. Such a presentation has not been previously reported. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900269
更新日期：1998-03-01 00:00:00
abstract：:Ectopic atrial tachycardia (EAT) is often resistant to medical therapy, with radiofrequency ablation (RFA) being a preferred treatment option. Three-dimensional (3-D) electroanatomic mapping was introduced as a tool for improved substrate localization, although there are no published data with this technology in pedia...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-007-9137-4
更新日期：2008-03-01 00:00:00
abstract：:Our objective was to evaluate and highlight the significance of epigastric tenderness in children and adolescents with chest pain. In a 26-months period, patients who were referred for pediatri cardiology evaluation at Shiraz University of Medical Sciences with chief complaint of chest pain were studied. Patients with...
journal_title：Pediatric cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00246-002-0077-8
更新日期：2003-01-01 00:00:00
abstract：:Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the numerous studies undertaken to functionally characterize these TFs, their exact role in different...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02099-y
更新日期：2019-06-01 00:00:00
abstract：:All 91,823 children born in 1980 in Bohemia (population 6.314 million; area 52,478 square kilometers) were examined at least four times during infancy and at the age of three and four years. All children who died were autopsied and those with heart disease were selected. A total of 779 children (8.223/1000 live births...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF02083294
更新日期：1989-10-01 00:00:00
abstract：:Different devices have been used for percutaneous closure of ventricular septal defects (VSDs). Over the past 6 months, we have used the Amplatzer duct occluder for VSDs associated with tunnel-shaped aneurysm in three patients here at our institution. Due to the anatomic resemblance between such VSDs and the duct occl...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9092-0
更新日期：2008-03-01 00:00:00
abstract：:An aneurysm of the fossa ovalis was identified at autopsy in 17 infants. In each case the aneurysm of the fossa ovalis was considered to have resulted from excessive elevation of pressure in that atrium contralateral to the side into which the aneurysm bulged. The aneurysms were divided into two types: intrinsic (thre...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02282740
更新日期：1985-01-01 00:00:00
abstract：:We present an infant with unusual anatomy and physiology of a persistent left superior vena cava (LSVC). The adverse physiologic consequences of the LSVC were corrected with percutaneous placement of vascular plugs. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-009-9617-9
更新日期：2010-05-01 00:00:00
abstract：:Conotruncal cardiac defects are partially prevented by maternal folic acid supplementation. However, the biochemical mechanism is unknown. Maternal autoantibodies to folate receptors, previously associated with increased risk for neural tube defects, also may account for this effect. This study aimed to examine the ti...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0485-3
更新日期：2013-03-01 00:00:00
abstract：:A hemodynamically stable neonate with transposition of the great arteries suddenly went into cardiac arrest during preparation for transport to the operating room. Emergency echocardiography during cardiac massage detected coronary air embolism as the presumed cause of arrest. After about 15 minutes of resuscitation, ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0088-4
更新日期：2011-12-01 00:00:00
abstract：:We undertook a study to identify the hemodynamic significance of a Doppler-derived gradient across a stenotic pulmonary valve. Furthermore, we attempted to define the optimal plane for velocity data acquisition. A total of 17 children with valvar pulmonary stenosis were evaluated using Doppler echocardiography. Flow-v...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02081678
更新日期：1989-07-01 00:00:00
