Rho-kinase in development and heart failure: insights from genetic models.


:Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C, PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of small GTPase RhoA. Rho-kinase is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, and proliferation. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be functionally redundant, based largely on the major common activators, the high degree of homology within the kinase domain, and studies from overexpression with kinase constructs and chemical inhibitors (e.g., Y27632 and fasudil), which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms. This review focuses on the current understanding of ROCK isoform biology, with a particular emphasis on their functions in mouse development and the pathogenesis of heart failure.


Pediatr Cardiol


Pediatric cardiology


Shi J,Zhang L,Wei L




Has Abstract


2011-03-01 00:00:00












  • Closure of symptomatic ventricular septal defects: how early is too early?

    abstract::With improvements in technology and surgical technique, pediatric cardiologists are challenging surgeons to close symptomatic ventricular septal defects (VSDs) in ever smaller patients. Although delaying surgery may facilitate operative repair, early intervention decreases the period of time these patients require the...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kogon B,Butler H,Kirshbom P,Kanter K,McConnell M

    更新日期:2008-01-01 00:00:00

  • Transcatheter Intervention for Treatment of Coronary Stenosis After Unroofing of the Anomalous Left Coronary Artery.

    abstract::Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Chakraborty A,Mendoza C,Infante J,Sandhu SK

    更新日期:2019-01-01 00:00:00

  • Bartonella henselae endocarditis in a child.

    abstract::14-year-old white male with a past medical history of congenital bicuspid aortic valve, Streptococcus viridans endocarditis, and pulmonary valve homograft presented with culture-negative endocarditis. Molecular studies identified the causative organism as Bartonella henselae and subsequent serologic studies supported ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Pitchford CW,Creech CB 2nd,Peters TR,Vnencak-Jones CL

    更新日期:2006-11-01 00:00:00

  • Hypoplastic left heart syndrome and valvar pulmonary stenosis: presentation and management.

    abstract::We describe the first report of an infant who was born with hypoplastic left heart syndrome and significant pulmonary stenosis. He was successfully palliated with multiple cardiac catheterization interventions while waiting for cardiac transplantation. This unusual constellation of heart defects is an entity that is r...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Farra H,Kort HW

    更新日期:2005-09-01 00:00:00

  • Malignant fibrosarcoma with features of myxoma.

    abstract::Left atrial tumor, diagnosed as myxoma at first investigation, was later demonstrated to be a malignant fibrosarcoma with myxoid change. Myxoma should be diagnosed and managed carefully because of its wide range of histopathologic features. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Hishitani T,Ogawa K,Hoshino K,Kido S,Nakamura Y,Ogawa Y

    更新日期:2001-05-01 00:00:00

  • Active surveillance of sudden cardiac death in young athletes by periodic Internet searches.

    abstract::The authors hypothesized that prospective, systematic Internet searches could identify occurrences of sudden cardiac death (SCD) in athletes and would be useful for establishing a system of active surveillance. Weekly advanced Google searches of the Internet were conducted for cases of SCD in young athletes during a 1...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Choi K,Pan YP,Pock M,Chang RK

    更新日期:2013-01-01 00:00:00

  • Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease.

    abstract::The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Vincentz JW,Rubart M,Firulli AB

    更新日期:2012-08-01 00:00:00

  • Two-dimensional echocardiographic visualization of the aortic arch by right parasternal scanning in neonates and infants.

    abstract::Echocardiography has previously been of limited use in visualizing the aorta in neonates and infants. Using a new technique--right parasternal scanning--the aortic arch and brachiocephalic vessels were studied in 50 children under 18 months of age. Complete visualization was accomplished in 47 patients including those...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: George L,Waldman JD,Kirkpatrick SE,Turner SW,Pappelbaum SJ

    更新日期:1982-01-01 00:00:00

  • Echocardiographic evaluation of systolic and diastolic function in postoperative coarctation patients.

    abstract::Postoperative coarctation (CoA) patients are often found to have signs of persistent myocardial dysfunction. M-mode echocardiography was performed to study left ventricular (LV) size, mass, and systolic function and Doppler ultrasonography to study LV filling and flow velocity in the LV outflow tract and aorta in 28 "...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sigurdardóttir LY,Helgason H

    更新日期:1997-03-01 00:00:00

  • Identification of Gene Mutations in Primary Pediatric Cardiomyopathy by Whole Exome Sequencing.

    abstract::Pediatric primary cardiomyopathy is rare but serious, having high mortality; hypertrophic and dilated types are the most common. Its etiology has been mainly considered idiopathic; however, next generation sequencing techniques have revealed nearly half of idiopathic pediatric cases arose from specific genetic mutatio...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Rojnueangnit K,Sirichongkolthong B,Wongwandee R,Khetkham T,Noojarern S,Khongkraparn A,Wattanasirichaigoon D

    更新日期:2020-01-01 00:00:00

  • Plasmatic [corrected] factor XIII reduces severe pleural effusion in children after open-heart surgery.

    abstract::Chylous effusions frequently occur after cardiac surgery due to severe damage to the lymphatic system, thus indicating that the insertion of a chest tube may be necessary. Factor XIII (FXIII) is discussed as being essential for wound healing. The aim of this retrospective study was to evaluate whether the application ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Schroth M,Meißner U,Cesnjevar R,Weyand M,Singer H,Rascher W,Klinge J

    更新日期:2006-01-01 00:00:00

  • Utility of Doppler tissue imaging-derived indices in identifying subclinical systolic ventricular dysfunction in children with restrictive cardiomyopathy.

    abstract::Restrictive cardiomyopathy (RCM) is characterized by irreversible diastolic dysfunction with preserved systolic function. The aim of this study was to investigate the presence of impaired ventricular contractility even in the presence of normal ejection fraction (EF) in children with RCM. Longitudinal Doppler tissue v...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sasaki N,Garcia M,Lytrivi I,Ko H,Nielsen J,Parness I,Srivastava S

    更新日期:2011-06-01 00:00:00

  • Transcatheter management of subtotal cor triatriatum sinister: a rare anomaly.

    abstract::Subtotal cor triatriatum sinister (partially divided left atrium) is characterized by a membrane dividing the left atrium into two portions: a dorsal accessory proximal chamber that receives part of the pulmonary venous return and a small restrictive defect in the membrane that obstructs blood flow from the accessory ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Sivakumar K,Satish R,Tailor K,Coelho R

    更新日期:2008-07-01 00:00:00

  • An old autopsy report sheds light on a "new" disease: infantile polyarteritis nodosa and kawasaki disease.

    abstract::Although Kawasaki disease (KD) was first discovered and identified in Japan by Kawasaki in the 1960s, fatal KD cases resulting from coronary artery aneurysms had been identified retrospectively in the West as early as 1871. Kawasaki initially postulated that this disease was a new, as yet unidentified, self-limiting i...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kushner HI,Abramowsky CR

    更新日期:2010-05-01 00:00:00

  • Aneurysm of the ventricular membranous septum: serial echocardiographic studies.

    abstract:OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Miyake T,Shinohara T,Nakamura Y,Fukuda T,Tasato H,Toyohara K,Tanihira Y

    更新日期:2004-07-01 00:00:00

  • Paradoxical relationship between B-type natriuretic peptide and pulmonary vascular resistance in patients with ventricular septal defect and concomitant severe pulmonary hypertension.

    abstract::B-type natriuretic peptide (BNP) reflects volume overload on left ventricle and pulmonary hypertension (PH) in patients with ventricular septal defect (VSD). Pulmonary vascular resistance (PVR) has been reported to correlate positively with BNP in VSD patients with various degrees of PH. We aimed to investigate the re...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Toyono M,Harada K,Tamura M,Aoki-Okazaki M,Shimada S,Oyamada J,Takada G

    更新日期:2008-01-01 00:00:00

  • Spontaneous resolution of atrioventricular dissociation in utero.

    abstract::Fetal atrioventricular dissociation is a dysrhythmia associated with significant antenatal and postnatal morbidity and mortality. We present a case of a 19-week-old fetus with atrioventricular dissociation, which spontaneously resolved. The mother had no signs of autoimmune disease. The fetus had an uneventful gestati...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Boris JR,Drose JA,Schaffer MS,Shaffer EM

    更新日期:1998-11-01 00:00:00

  • Results of surgical treatment of congenital heart defects in children with Down's syndrome.

    abstract::We analyzed early and late results of surgical treatment of 100 consecutive children with Down's syndrome (DS) and congenital heart defect (CHD) who were operated on between 1990 and 1997. Fifty had common atrioventricular canal (CAVC), 24 ventricular septal defect, 8 the ostium primum atrial septal defect, 8 tetralog...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Malec E,Mroczek T,Pajak J,Januszewska K,Zdebska E

    更新日期:1999-09-01 00:00:00

  • First case of intracardiac foregut cyst occurring in the left-ventricular outflow tract.

    abstract::An 11 day-old female infant underwent resection of a mass in the subaortic region secondary to critical aortic stenosis. At 3 months of age, recurrent severe left-ventricular outflow obstruction (LVOT) in the setting of heart failure prompted redo surgery, and the resected mass revealed an intracardiac foregut cyst, w...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Huang JH,Rudzinski ER,Minette MS,Langley SM

    更新日期:2013-01-01 00:00:00

  • Ventricular Arterial Coupling: A Novel Echocardiographic Risk Factor for Disease Progression in Pediatric Dilated Cardiomyopathy.

    abstract::In adult heart failure (HF) patients, a higher ventricular arterial (VA) coupling ratio measured non-invasively is associated with worse HF prognosis and response to treatment. There are no data regarding the relationship of VA coupling to outcome in pediatric dilated cardiomyopathy (DCM) patients. We investigated the...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Capone CA,Lamour JM,Lorenzo J,Tria B,Ye K,Hsu DT,Mahgerefteh J

    更新日期:2019-02-01 00:00:00

  • Myocardial calcification caused by secondary hyperparathyroidism due to dietary deficiency of calcium and vitamin D.

    abstract::A 6-year-old girl presented with respiratory distress. Chest radiographs exhibited calcifications in the mediastinum. Further imaging revealed extensive cardiac calcifications on computed tomography of the chest. The laboratory parameters were consistent with findings of secondary hyperparathyroidism. Detailed review ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Zaidi AN,Ceneviva GD,Phipps LM,Dettorre MD,Mart CR,Thomas NJ

    更新日期:2005-07-01 00:00:00

  • Prevalence of Sleep-Disordered Breathing in a Cohort of Adult Fontan Patients.

    abstract::Sleep-disordered breathing (SDB) is described in patients with acquired heart failure but its prevalence in adults with congenital heart disease is not well documented. It is likely that single-ventricle patients who have undergone Fontan palliation poorly tolerate the additional stress of SDB on their fragile cardiac...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Cg S,Rm J,Ad K,E Y,M K,G M,J K

    更新日期:2020-10-01 00:00:00

  • Intrapericardial and retrocardial implantation of implantable cardioverter-defibrillator lead in a child with type 3 long QT syndrome.

    abstract::A 6-year-old girl with type 3 long QT syndrome was safely and successfully implanted with an implantable cardioverter-defibrillator (ICD) system. Prior to implantation, she had experienced uncontrollable life-threatening arrhythmia in spite of high-dose administration of mexiletine. An ICD coil lead for transvenous us...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Ichikawa Y,Iwamoto M,Yanagi S,Masuda M

    更新日期:2011-10-01 00:00:00

  • Validation of cardiac output measurement by ultrasound dilution technique with pulmonary artery thermodilution in a pediatric animal model.

    abstract::Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (C...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Darling E,Thuramalla N,Searles B

    更新日期:2011-06-01 00:00:00

  • Congenital polyvalvular disease: a review.

    abstract::This review outlines the morphologic and pathogenetic characteristics of congenital polyvalvular disease. Two cases are used for exemplification. The macroscopic and histologic features of the valves as well as associated cardiac lesions and clinical syndromes are described, followed by a discussion of morphogenesis o...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Bartram U,Bartelings MM,Kramer HH,Gittenberger-de Groot AC

    更新日期:2001-03-01 00:00:00

  • Long-term outcome after surgical closure of atrial septal defect in childhood with extensive assessment including MRI measurement of the ventricles.

    abstract::Surgical closure of the secundum type of atrial septal defect (ASD) in childhood leads to excellent survival. However, relevant morbidity has been reported. Transcatheter closure of these defects has now become an alternative approach. To compare the results of the two different interventions, reliable data are needed...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Bolz D,Lacina T,Buser P,Buser M,Guenthard J

    更新日期:2005-09-01 00:00:00

  • Screening for Congenital Heart Disease in Infants with Down Syndrome: Is Universal Echocardiography Necessary?

    abstract::Current guidelines recommend that all neonates with Down syndrome (DS) be screened for congenital heart disease (CHD) with an echocardiogram. We sought to determine the effectiveness of a more accessible and less expensive screening strategy consisting of physical examination, electrocardiogram (ECG), and chest X-ray....

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Bogarapu S,Pinto NM,Etheridge SP,Sheng X,Liesemer KN,Young PC,Saarel EV

    更新日期:2016-10-01 00:00:00

  • Cardiac function in congenital hypothyroidism: impairment and response to L-T4 therapy.

    abstract::Electrocardiograms (heart rate, QRS voltage, QRS axis in the frontal plane. Q-Tc interval) echocardiograms [left ventricular fractional shortening (LVFS); preejection period (PEP); PEP/left ventricular ejection time (PEP/LVET) ratio; end-diastolic left ventricular free wall and interventricular septum thickness; prese...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Balducci G,Acquafredda A,Amendola F,Natuzzi M,Laforgia N,Cavallo L

    更新日期:1991-01-01 00:00:00

  • 1173C>T polymorphism in VKORC1 modulates the required warfarin dose.

    abstract::The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kosaki K,Yamaghishi C,Sato R,Semejima H,Fuijita H,Tamura K,Maeyama K,Yamagishi H,Sugaya A,Dodo H,Tanigawara Y,Takahashi T

    更新日期:2006-11-01 00:00:00

  • A Novel Somatic Variant in HEY2 Unveils an Alternative Splicing Isoform Linked to Ventricular Septal Defect.

    abstract::Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the numerous studies undertaken to functionally characterize these TFs, their exact role in different...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Fardoun M,Dehaini H,Kamar A,Bitar F,Majdalani M,El-Rassi I,Nemer G,Arabi M

    更新日期:2019-06-01 00:00:00