Rho-kinase in development and heart failure: insights from genetic models.


:Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C, PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of small GTPase RhoA. Rho-kinase is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, and proliferation. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be functionally redundant, based largely on the major common activators, the high degree of homology within the kinase domain, and studies from overexpression with kinase constructs and chemical inhibitors (e.g., Y27632 and fasudil), which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms. This review focuses on the current understanding of ROCK isoform biology, with a particular emphasis on their functions in mouse development and the pathogenesis of heart failure.


Pediatr Cardiol


Pediatric cardiology


Shi J,Zhang L,Wei L




Has Abstract


2011-03-01 00:00:00












  • Left Ventricular Mass Quantification by Two-Dimensional Echocardiography in a Pediatric Population: Correlation with Cardiac Magnetic Resonance Imaging.

    abstract::Quantification of left ventricular (LV) mass by echocardiography has not been validated against the gold standard of cardiac magnetic resonance imaging (CMR) in the pediatric population. The purpose of this study was to compare LV mass by two-dimensional and conventional M-mode echocardiography versus CMR in children....

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Chu BJ,Lee T,Gilbreth JG,Nielsen JC,Ludomirsky A,Tretter JT,Bhatla P

    更新日期:2019-02-01 00:00:00

  • Improved prenatal detection of congenital heart disease in an integrated health care system.

    abstract::The reported prenatal detection rates (PDRs) for significant congenital heart disease (sCHD) have been suboptimal, even in the current era. Changes in prenatal ultrasound policy and training may lead to improved prenatal detection of sCHD. This study analyzed the results of a policy to assess fetal cardiac outflow tra...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Levy DJ,Pretorius DH,Rothman A,Gonzales M,Rao C,Nunes ME,Bendelstein J,Mehalek K,Thomas A,Nehlsen C,Ehr J,Burchette RJ,Sklansky MS

    更新日期:2013-03-01 00:00:00

  • Ventricular repolarisation during exercise challenge occurring late after Kawasaki disease.

    abstract::Exercise testing can highlight repolarisation abnormalities in adults with coronary artery disease. Late after Kawasaki disease (KD), increased QT dispersion (QTd) has been reported on resting ECG in children, but there are no reported studies of QTd during exercise. Our objective was to determine the pattern of QTd r...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Gravel H,Dahdah N,Fournier A,Mathieu MÈ,Curnier D

    更新日期:2012-06-01 00:00:00

  • Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child.

    abstract::Midodrine hydrochloride is a potent peripherally-acting alpha1 agonist that is well absorbed and rapidly metabolized to its active metabolite. It has been used for the treatment of refractory syncope but has the important side effect of supine hypertension. A 10-year-old boy with severe symptomatic orthostatic hypoten...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Olgar S,Omeroglu RE

    更新日期:2007-07-01 00:00:00

  • Association of Hematocrit and Red Blood Cell Transfusion with Outcomes in Infants Undergoing Norwood Operation.

    abstract::The objective of this study was to investigate the association between red blood cell (RBC) transfusion and hematocrit values with outcomes in infants undergoing Norwood operation. This study included infants ≤2 months of age who underwent Norwood operation with either a modified Blalock-Taussig shunt or a right ventr...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Gupta P,King C,Benjamin L,Goodhart T,Robertson MJ,Gossett JM,Pesek GA,DasGupta R

    更新日期:2015-08-01 00:00:00

  • Pulmonary interstitial glycogenosis associated with pulmonary hypertension and hypertrophic cardiomyopathy.

    abstract::A neonate with pulmonary interstitial glycogenosis, pulmonary hypertension, and hypertrophic cardiomyopathy is described. The fatal outcome for this patient contrasts with the reported favorable prognosis associated with isolated pulmonary interstitial glycogenosis. To the authors' knowledge, the association of pulmon...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Alkhorayyef A,Ryerson L,Chan A,Phillipos E,Lacson A,Adatia I

    更新日期:2013-02-01 00:00:00

  • Prevalence of obesity among patients with congenital and acquired heart disease.

    abstract::Overweight and obesity rates have risen dramatically in the United States, with subsequent detrimental comorbidity risks. The rates for obesity among children with congenital and acquired heart disease have rarely been reported. A retrospective cross-sectional study was conducted to determine the prevalence of overwei...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Shustak RJ,McGuire SB,October TW,Phoon CK,Chun AJ

    更新日期:2012-01-01 00:00:00

  • Study on Maternal SNPs of MTHFR Gene and HCY Level Related to Congenital Heart Diseases.

    abstract::The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Shi H,Yang S,Lin N,Huang P,Yu R,Chen M,Wang L,Jiang Z,Sun X

    更新日期:2020-11-21 00:00:00

  • Normalization of maximal cardiovascular variables for body size in premenarcheal girls.

    abstract::Previous studies have indicated the importance of allometric scaling of VO2max for body size. However, no information is available on adjusting maximal cardiac output (Qmax) and stroke volume (SVmax) for body dimensions. The allometric exponent b was determined for the equation Y = aXb (where Y is the physiological ou...

    journal_title:Pediatric cardiology

    pub_type: 临床试验,杂志文章


    authors: Rowland T,Goff D,Martel L,Ferrone L,Kline G

    更新日期:2000-09-01 00:00:00

  • Epicardial Pacemaker in Neonates and Infants: Is There a Relationship Between Patient Size, Device Size, and Wound Complicatıon?

    abstract::We aimed to investigate the complications after epicardial pacemaker (PM) implantation in neonates and infants and their relationship with factors such as device size and patient size. Between May 2010 and July 2018, 55 patients under 1 year of age who underwent epicardial PM placement were retrospectively evaluated. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Ergün S,Kafalı HC,Genç SB,Yildiz O,Güneş M,Onan İS,Ergül Y,Güzeltaş A,Haydin S

    更新日期:2020-04-01 00:00:00

  • Lipoprotein (a): Examination of Cardiovascular Risk in a Pediatric Referral Population.

    abstract::Atherosclerotic cardiovascular disease (CVD), a leading cause of death globally, has origins in childhood. Major risk factors include family history of premature CVD, dyslipidemia, diabetes mellitus, and hypertension. Lipoprotein (a) [Lp(a)], an inherited lipoprotein, is associated with premature CVD, but its impact o...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Qayum O,Alshami N,Ibezim CF,Reid KJ,Noel-MacDonnell JR,Raghuveer G

    更新日期:2018-12-01 00:00:00

  • Loss of Consciousness in the Young Child.

    abstract::In the very young child (less than eight years of age), transient loss of consciousness represents a diagnostic and management dilemma for clinicians. While most commonly benign, syncope may be due to cardiac dysfunction which can be life-threatening. It can be secondary to an underlying ion channelopathy, cardiac inf...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Villafane J,Miller JR,Glickstein J,Johnson JN,Wagner J,Snyder CS,Filina T,Pomeroy SL,Sexson-Tejtel SK,Haxel C,Gottlieb J,Eghtesady P,Chowdhury D

    更新日期:2021-01-02 00:00:00

  • Morbidities in patients with hypoplastic left heart syndrome.

    abstract::We sought to document morbidities and growth for patients with hypoplastic left heart syndrome (HLHS) to inform the initial surgical decision and understand healthcare needs. Data were obtained on 137 patients with HLHS, born between 1989 and 1994, who survived staged surgery ( n = 62) or transplantation ( n = 75) and...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究


    authors: Jenkins PC,Flanagan MF,Jenkins KJ,Sargent JD,Canter CE,Chinnock RE,Vincent RN,O'Connor GT

    更新日期:2004-01-01 00:00:00

  • Fifteen-year single center experience with the "Giessen Hybrid" approach for hypoplastic left heart and variants: current strategies and outcomes.

    abstract::Presented is a retrospective outcome study of a 15-year single institutional experience with a contemporary cohort of patients with hypoplastic left heart syndrome and complex that underwent a "Giessen Hybrid" stage I as initial palliation. Hybrid approach consisting of surgical bilateral pulmonary artery banding and ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Schranz D,Bauer A,Reich B,Steinbrenner B,Recla S,Schmidt D,Apitz C,Thul J,Valeske K,Bauer J,Müller M,Jux C,Michel-Behnke I,Akintürk H

    更新日期:2015-02-01 00:00:00

  • Value of the echocardiographic findings of arrhythmogenic right ventricular dysplasia with left ventricular involvement in a child.

    abstract::A 9-year-old girl was admitted because she had had palpitations for 2 years. Her electrocardiogram revealed multifocal ectopic beats with left bundle branch morphology, sinoatrial block, and first- and second-degree atrioventricular blocks. Cross-sectional echocardiography demonstrated an enlarged left ventricle and f...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Atalay S,Imamoglu A,Gümüs H,Gürdal M,Ozenci M

    更新日期:1996-01-01 00:00:00

  • Progressive congenital valvar aortic stenosis during infancy: five cases.

    abstract::We report our experience with asymptomatic valvar aortic stenosis diagnosed during infancy. During the period between November 1, 1986 and October 31, 1992 a total of 13 infants were diagnosed with asymptomatic aortic stenosis, 5 of whom showed rapid progression over the first 2 years of life. Two of these asymptomati...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Anand R,Mehta AV

    更新日期:1997-01-01 00:00:00

  • Aortic valvar atresia, interrupted aortic arch, and quadricuspid pulmonary valve: a rare combination.

    abstract::Aortic atresia and interrupted aortic arch is a rare cardiac combination. Review of the literature revealed nine cases. We present two patients with this combination and the additional finding of quadricuspid pulmonary valves, one of which was severely stenotic. In the latter patient, an aortopulmonary window was pres...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Yew G,Coleman D,Calder L

    更新日期:2005-07-01 00:00:00

  • Dual atrioventricular nodal non-reentrant tachycardia in a child undergoing repair of ventricular septal defect.

    abstract::Paroxysmal non-reentrant supraventricular tachycardia due to double ventricular response through antegrade dual atrioventricular nodal pathways by a single atrial excitation has been reported in limited adult cases but not in pediatric patients with structurally normal hearts or with congenital heart defects. We repor...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Takahashi K,Nakayashiro M,Ganaha H

    更新日期:2013-03-01 00:00:00

  • Evaluation of Impedance Cardiography for Measurement of Stroke Volume in Congenital Heart Disease.

    abstract::Noninvasive measurement of cardiac output (CO) and particularly stroke volume (SV) remain difficult but potentially valuable. These variables can be particularly challenging to measure in children with congenital heart disease (CHD). Impedance cardiography (IC) is a technique shown to be accurate in measuring SV in ad...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Ebrahim M,Hegde S,Printz B,Abcede M,Proudfoot JA,Davis C

    更新日期:2016-12-01 00:00:00

  • Influence of repeated bouts of table tennis training on cardiac biomarkers in children.

    abstract::It is documented that exercise can increase serum cardiac troponins in adults and adolescents; however, there is a lack of related studies concerning the release of cardiac troponins in children. This study investigated the influence of table tennis training on cardiac biomarkers in children. Twenty-eight male childre...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Ma G,Liu Y,Liu K

    更新日期:2014-04-01 00:00:00

  • 1173C>T polymorphism in VKORC1 modulates the required warfarin dose.

    abstract::The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kosaki K,Yamaghishi C,Sato R,Semejima H,Fuijita H,Tamura K,Maeyama K,Yamagishi H,Sugaya A,Dodo H,Tanigawara Y,Takahashi T

    更新日期:2006-11-01 00:00:00

  • Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease.

    abstract::The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审


    authors: Vincentz JW,Rubart M,Firulli AB

    更新日期:2012-08-01 00:00:00

  • Successful management of isolated ventricular inversion in an adult.

    abstract::We report a case of isolated ventricular inversion in a 42-year-old woman. This rare congenital cardiac anomaly was corrected by an intraatrial baffle procedure. She also underwent left-sided double-chamber endocardial pacemaker implantation for postoperative tachycardia bradycardia syndrome. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kannan BR,Kamath KP,Rao SG,Kumar RK

    更新日期:2004-09-01 00:00:00

  • Fetal interventions for congenital heart disease in Brazil.

    abstract::Fetal interventions have been performed for some congenital heart diseases. However, these procedures have not gained wide acceptance due to concerns about their efficacy and safety. The aim of this study was to report on a preliminary experience with fetal cardiac interventions in Brazil. Twenty-two cardiac intervent...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Pedra SR,Peralta CF,Crema L,Jatene IB,da Costa RN,Pedra CA

    更新日期:2014-03-01 00:00:00

  • Association of DNMT1 Gene Polymorphisms with Congenital Heart Disease in Child Patients.

    abstract::To reveal the association between DNMT1 polymorphisms and congenital heart disease (CHD) in child patients, a total of 224 CHD child patients as well as 199 healthy individuals were enrolled in the present study. The DNA was extracted from whole blood, and four SNPs including rs16999593, rs2228612, rs2288349 and rs104...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Wang F,Zhou S,Wang Y,Wang L,Zhou J,Wang H,Li C,Chang M

    更新日期:2015-06-01 00:00:00

  • Elective Non-Urgent Balloon-Atrial Septostomy in Infants with d-Transposition of the Great Arteries Does Not Eliminate the Need for PGE1 Therapy at the Time of Arterial Switch Operation.

    abstract::Once a mainstay in the treatment of neonates with d-transposition of the great arteries (d-TGA), the application of balloon atrial septostomy (BAS) in the d-TGA population has become more selective. Currently, there is no clear evidence for or against a selective BAS strategy. The aims of this single-center retrospect...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Zaleski KL,McMullen CL,Staffa SJ,Thiagarajan RR,Maschietto N,DiNardo JA,Nasr VG

    更新日期:2021-01-25 00:00:00

  • Right Ventricular Mechanical Dyssynchrony in Hypoplastic Left Heart Syndrome: Correlation with Systolic Function and QRS Duration.

    abstract::The single right ventricle (RV) in hypoplastic left heart syndrome (HLHS) often develops systolic dysfunction with time and this affects prognosis. Mechanical dyssynchrony has been reported in HLHS but has not consistently correlated with systolic function or electrical dyssynchrony. The aims of this study were to ass...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Zaidi SJ,Penk J,Cui VW,Roberson DA

    更新日期:2019-06-01 00:00:00

  • An old autopsy report sheds light on a "new" disease: infantile polyarteritis nodosa and kawasaki disease.

    abstract::Although Kawasaki disease (KD) was first discovered and identified in Japan by Kawasaki in the 1960s, fatal KD cases resulting from coronary artery aneurysms had been identified retrospectively in the West as early as 1871. Kawasaki initially postulated that this disease was a new, as yet unidentified, self-limiting i...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Kushner HI,Abramowsky CR

    更新日期:2010-05-01 00:00:00

  • Doppler estimation of pressure gradient in pulmonary stenosis: maximal instantaneous vs peak-to-peak, vs mean catheter gradient.

    abstract::We undertook a study to identify the hemodynamic significance of a Doppler-derived gradient across a stenotic pulmonary valve. Furthermore, we attempted to define the optimal plane for velocity data acquisition. A total of 17 children with valvar pulmonary stenosis were evaluated using Doppler echocardiography. Flow-v...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Aldousany AW,DiSessa TG,Dubois R,Alpert BS,Willey ES,Birnbaum SE

    更新日期:1989-07-01 00:00:00

  • Tricuspid atresia with progressive ductal restriction in a fetus.

    abstract::We report a unique case of tricuspid and pulmonary atresia with idiopathic progressive ductus arteriosus restriction in utero. Diligent predelivery planning and a controlled delivery environment led to a favorable outcome. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章


    authors: Lowenthal A,Lal A,Selamet Tierney ES,Tacy TA

    更新日期:2013-08-01 00:00:00