Abstract:
:Rho-kinase (ROCK) belongs to the AGC (protein kinase A/protein kinase G/protein kinase C, PKA/PKG/PKC) family of serine/threonine kinases and is a major downstream effector of small GTPase RhoA. Rho-kinase is involved in a wide range of fundamental cellular functions such as contraction, adhesion, migration, and proliferation. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be functionally redundant, based largely on the major common activators, the high degree of homology within the kinase domain, and studies from overexpression with kinase constructs and chemical inhibitors (e.g., Y27632 and fasudil), which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms. This review focuses on the current understanding of ROCK isoform biology, with a particular emphasis on their functions in mouse development and the pathogenesis of heart failure.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Shi J,Zhang L,Wei Ldoi
10.1007/s00246-011-9920-0subject
Has Abstractpub_date
2011-03-01 00:00:00pages
297-304issue
3eissn
0172-0643issn
1432-1971journal_volume
32pub_type
杂志文章,评审abstract::Little has been published about specific problems that may occur during long-distance transports of newborn cardiac patients. During a 4-year period after centralization of pediatric heart surgery in Sweden, 286 transports were prospectively investigated. A majority (77.3%) of the transports were carried out by nonspe...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010254
更新日期:2001-09-01 00:00:00
abstract::Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02238841
更新日期:1990-07-01 00:00:00
abstract::The development of Leadless cardiac pacemakers avoids the inherent complications that may occur secondary to lead insertion. A large number of devices have been inserted in adult patients although data in pediatric patients are lacking. We aimed to assess our experience with the Leadless device in the pediatric popula...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02277-y
更新日期:2020-04-01 00:00:00
abstract::Congenitally corrected transposition of the great arteries is a rare anomaly that is thought to arise from a defect in looping of the primitive cardiac tube. Cor triatriatum is another rare congenital cardiac anomaly due to faulty incorporation of the common pulmonary vein into the left atrium. We present a rare case ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-9912-0
更新日期:2011-04-01 00:00:00
abstract::All 91,823 children born in 1980 in Bohemia (population 6.314 million; area 52,478 square kilometers) were examined at least four times during infancy and at the age of three and four years. All children who died were autopsied and those with heart disease were selected. A total of 779 children (8.223/1000 live births...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/BF02083294
更新日期:1989-10-01 00:00:00
abstract::While exercise stress testing (EST) is an important tool, little is known about its use for determining ischemia in patients with hypoplastic left heart syndrome (HLHS) and Fontan palliation. We sought to determine the frequency of ST segment changes during EST in HLHS patients after Fontan and examine results of furt...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-015-1312-4
更新日期:2016-03-01 00:00:00
abstract::The timing of pulmonary valve replacement (PVR) in asymptomatic patients with repaired tetralogy of Fallot (TOF) is typically based on cardiac magnetic resonance imaging-derived ventricular volume measurements. Current criteria do not account for sex-based differences in chamber size. The purpose of this study was to ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02181-5
更新日期:2019-10-01 00:00:00
abstract::We aimed to investigate the complications after epicardial pacemaker (PM) implantation in neonates and infants and their relationship with factors such as device size and patient size. Between May 2010 and July 2018, 55 patients under 1 year of age who underwent epicardial PM placement were retrospectively evaluated. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02306-1
更新日期:2020-04-01 00:00:00
abstract::Severe atrioventricular valve (AVV) or semilunar valve (SLV) regurgitation in the setting of a single ventricle physiology may proceed to valve replacement if repair strategies fail. Outcome data for these children are limited. We present transplant-free survival of a case series of children with single ventricle phys...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02234-9
更新日期:2020-01-01 00:00:00
abstract::Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the numerous studies undertaken to functionally characterize these TFs, their exact role in different...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02099-y
更新日期:2019-06-01 00:00:00
abstract::Kawasaki disease (KD) is an acute febrile disease of unknown etiology that develops in children and is sometimes accompanied by myocardial dysfunction and systemic vasculitis. However, myocardial repolarization lability has not yet been fully investigated. Thus, the objective of this study was to evaluate myocardial r...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-011-9908-9
更新日期:2011-04-01 00:00:00
abstract::Although the Fontan operation can improve outcomes, surviving patients still face Fontan-associated liver disease (FALD). The aim of this study was to determine the associated factors of FALD in relation to ultrasound liver elastography. A cross-sectional study was conducted for all patients on whom an ultrasound uppe...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02422-y
更新日期:2020-12-01 00:00:00
abstract::With improvements in technology and surgical technique, pediatric cardiologists are challenging surgeons to close symptomatic ventricular septal defects (VSDs) in ever smaller patients. Although delaying surgery may facilitate operative repair, early intervention decreases the period of time these patients require the...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9016-z
更新日期:2008-01-01 00:00:00
abstract::Angiotensin-converting enzyme inhibitors (ACEi) are commonly used for pediatric cardiology patients. However, studies examining their safety for neonates with cardiac disease are scarce. The current study aimed to test the hypothesis that ACEi-mediated nephrotoxicity occurs in neonates and may be underappreciated in t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0813-2
更新日期:2014-03-01 00:00:00
abstract::Various surgical techniques have been proposed for the repair of supravalvular pulmonary stenosis (SVPS) in pediatric populations. Whereas growth potential should be promised, excessive expansion under the presence of undiminished high pulmonary arterial pressure should be avoided. The authors applied all-autologous t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0698-0
更新日期:2013-10-01 00:00:00
abstract::The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02449-1
更新日期:2020-11-21 00:00:00
abstract::The Norwood procedure with a modified Blalock-Taussig shunt (MBTS) is the first of the three-stage surgical palliation for infants with hypoplastic left heart syndrome. We report a patient with schistocytic hemolytic anemia that developed following a right MBTS with a Gore-Tex graft. Hemolysis associated with a MBTS h...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-006-1410-4
更新日期:2007-05-01 00:00:00
abstract::Device closure of atrial septal defects (ASDs) is rapidly becoming routine in children. Comparisons are often made to older surgical series with higher morbidities. However outcomes including reintervention, late failure, and the need for long-term follow-up must be considered and compared to those of a current surgic...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-002-0131-6
更新日期:2003-09-01 00:00:00
abstract::Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder characterized by large-scale deletions of mitochondrial DNA. Neuromuscular and cardiac conduction systems are most commonly involved in these patients. Here, we discuss a 10-year-old patient with diabetes mellitus who presented in complete heart block leadin...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9040-z
更新日期:2008-05-01 00:00:00
abstract::Surgical closure of the secundum type of atrial septal defect (ASD) in childhood leads to excellent survival. However, relevant morbidity has been reported. Transcatheter closure of these defects has now become an alternative approach. To compare the results of the two different interventions, reliable data are needed...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-005-0838-2
更新日期:2005-09-01 00:00:00
abstract::We present two term neonates in which intravenous indomethacin usage was associated with successful closure of a persistently patent arterial duct. Both children had congenital heart disease with high pulmonary blood flow following surgical placement of contralateral systemic-pulmonary artery shunts. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0886-z
更新日期:2005-09-01 00:00:00
abstract::Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (C...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-9915-x
更新日期:2011-06-01 00:00:00
abstract::The slope of the relation between the unadjusted QT interval and heart rate during the face immersion test has been reported to be useful as an index for predicting an abnormal lengthening of the QT interval for children with nonfamilial long QT syndrome. Our goals were to determine whether we can replace the slope of...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-001-0034-y
更新日期:2002-03-01 00:00:00
abstract::Increased risk of perioperative hemorrhage has been described in patients with Turner syndrome and coarctation of the aorta. We have operated on 11 patients with Turner syndrome and coarctation of the aorta, two of whom developed bleeding. One patient died. End-to-end anastomosis was performed in all patients. Histolo...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02427041
更新日期:1984-07-01 00:00:00
abstract::A case of cerebral hemorrhage associated with sildenafil (Revatio) use in an infant is presented. Sildenafil is increasingly used in the treatment of primary and secondary pulmonary arterial hypertension and pulmonary arteriovenous fistula. In the reported case, sildenafil used to treat pulmonary arteriovenous fistula...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9460-z
更新日期:2009-10-01 00:00:00
abstract::Acute pulmonary vasodilator testing (AVT) is essential to determining the initial therapy for children with pulmonary arterial hypertension (PAH). This study aimed to report the initial experience with inhaled treprostinil used for AVT in children with PAH and to evaluate the hemodynamic change after inhaled treprosti...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0597-9
更新日期:2013-04-01 00:00:00
abstract::The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shu...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0462-x
更新日期:2013-02-01 00:00:00
abstract::Unroofed coronary sinus is a rare cardiac anomaly in which communication occurs between the coronary sinus and the left atrium due to the partial or complete absence of the roof of the coronary sinus. It is usually associated with other cardiovascular anomalies, especially persistent left superior vena cava. It is oft...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010087
更新日期:2000-07-01 00:00:00
abstract::Cardiac surgery for congenital heart disease often necessitates a period of myocardial ischemia during cardiopulmonary bypass and cardioplegic arrest, followed by reperfusion after aortic cross-clamp removal. In experimental models, myocardial ischemia-reperfusion is associated with significant oxidative stress and ve...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1345-3
更新日期:2016-04-01 00:00:00
abstract::For adults with sickle cell disease (SCD), cardiac changes are well described and may account for up to one-fourth of disease-related mortality. Much less is known about heart disease in pediatric SCD patients. This retrospective study analyzed a contemporary cohort of children with SCD followed at a single tertiary c...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0587-y
更新日期:2013-04-01 00:00:00