Insights into the characteristics of mammalian cardiomyocyte terminal differentiation shown through the study of mice with a dysfunctional c-kit.

Abstract:

:Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically indistinguishable from those of wild type mice, except that they are capable of proliferation in vivo after acute pressure overload. This review explores the idea that postnatal cardiomyocyte differentiation and cell cycle withdrawal are distinct processes and that terminal differentiation may not simply be due to altered expression of genes that regulate the cell cycle but could involve c-kit induced epigenetic change.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Naqvi N,Li M,Yahiro E,Graham RM,Husain A

doi

10.1007/s00246-008-9366-1

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

651-8

issue

5

eissn

0172-0643

issn

1432-1971

journal_volume

30

pub_type

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