Abstract:
:Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically indistinguishable from those of wild type mice, except that they are capable of proliferation in vivo after acute pressure overload. This review explores the idea that postnatal cardiomyocyte differentiation and cell cycle withdrawal are distinct processes and that terminal differentiation may not simply be due to altered expression of genes that regulate the cell cycle but could involve c-kit induced epigenetic change.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Naqvi N,Li M,Yahiro E,Graham RM,Husain Adoi
10.1007/s00246-008-9366-1subject
Has Abstractpub_date
2009-07-01 00:00:00pages
651-8issue
5eissn
0172-0643issn
1432-1971journal_volume
30pub_type
杂志文章abstract::Since its first description in Japan 30 years ago, Kawasaki disease has been reported worldwide. Although an infectious etiology is suspected based on the epidemiology and clinical features, a causative agent has not been identified. The majority of the morbidity and mortality associated with this condition is attribu...
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