Abstract：
:The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shunts after transplantation or at autopsy. Histologic sections were reviewed manually and by automated digital image analysis. Velocity vector imaging was performed on echocardiogram images obtained before transplant or death. All of these parameters were compared between the Sano and MBT shunt cohorts. A total of 14 specimens (7 Sano and 7 MBT shunt) were studied. Median age at transplant/death of Sano and MBT shunt cohorts was 11 (range 2-41) and 8 months (range 2-200), respectively. All Sano specimens had a scar at ventriculotomy site, and the mean scar area was 6.2 ± 3.3 cm(2). Compared with remote RV free wall, myocardium bordering the scar showed increased fibrosis (34 ± 16 % vs. 28 ± 14 %, p = 0.04) and thinning (0.8 ± 0.9 vs. 5.3 ± 0.8 mm; p < 0.001), which did not regress with time. The Sano ventriculotomy site showed significantly decreased velocity, strain, and strain rate compared with the corresponding contralateral segment. No focal scarring or regional hypokinesia was seen in the MBT shunt cohort. This is the first study to demonstrate histopathological features of ventriculotomy-associated RV myocardial scarring and myocardial thinning. The scarred ventriculotomy site showed decreased segmental myocardial deformation after Norwood with Sano shunt.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Menon SC,Erickson LK,McFadden M,Miller DVdoi
10.1007/s00246-012-0462-xsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
354-63issue
2eissn
0172-0643issn
1432-1971journal_volume
34pub_type
杂志文章abstract：:Fetal interventions have been performed for some congenital heart diseases. However, these procedures have not gained wide acceptance due to concerns about their efficacy and safety. The aim of this study was to report on a preliminary experience with fetal cardiac interventions in Brazil. Twenty-two cardiac intervent...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0792-3
更新日期：2014-03-01 00:00:00
abstract：:Magnetocardiographic mapping was performed on a 2-year-old boy who suffered from the Wolff-Parkinson-White syndrome in association with a complex congenital heart defect. The pre-excitation site was determined noninvasively from the measured cardiac magnetic fields. The location was in the same anatomic region as foun...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310333
更新日期：1995-01-01 00:00:00
abstract：:Pulmonary artery banding (PAB) is used as a surgical palliation to reduce excessive pulmonary blood flow caused by congenital heart defects. Due to the lack of microscopic studies dealing with the tissue remodeling caused by contemporary PAB materials, this study aimed to assess histologic changes associated with PAB ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0699-z
更新日期：2013-10-01 00:00:00
abstract：:From 1981 through June 1989, 59 children had surgery for a complete atrioventricular (AV) canal defect at Oregon Health Sciences University. We compared the morbidity, mortality, and hemodynamic status of 47 children with and 12 without Down's syndrome through review of operative, clinical, and cardiac catheterization...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00798209
更新日期：1992-04-01 00:00:00
abstract：:The slope of the relation between the unadjusted QT interval and heart rate during the face immersion test has been reported to be useful as an index for predicting an abnormal lengthening of the QT interval for children with nonfamilial long QT syndrome. Our goals were to determine whether we can replace the slope of...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-001-0034-y
更新日期：2002-03-01 00:00:00
abstract：:In a patient with single ventricle, mitral atresia, common atrium, pulmonary stenosis, azygos continuation of the inferior vena cava and bilateral systemic artery--pulmonary artery anastomoses, the systemic veins were connected directly to the pulmonary arteries to achieve physiologic repair; the child was discharged ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:This report aims to summarize and evaluate the efficacy and experience of reintervention for children with postoperative pulmonary venous restenosis. Clinical data from 61 patients with postoperative pulmonary venous restenosis who underwent reintervention at Shanghai Children's Medical Center (SCMC) from September 20...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02098-z
更新日期：2019-06-01 00:00:00
abstract：:Paroxysmal non-reentrant supraventricular tachycardia due to double ventricular response through antegrade dual atrioventricular nodal pathways by a single atrial excitation has been reported in limited adult cases but not in pediatric patients with structurally normal hearts or with congenital heart defects. We repor...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0326-4
更新日期：2013-03-01 00:00:00
abstract：:We studied the safety and efficacy of closing patent ductus arteriosus by Nit-Occlud coils via retrograde approach. This is a retrospective study of 46 attempts to close ducts by this method in two hospitals in Egypt and Iran. Ductus arteriosus was crossed by left or right Judkins or endhole catheters. The coil was de...
journal_title：Pediatric cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00246-017-1589-6
更新日期：2017-04-01 00:00:00
abstract：:Angiography remains the gold standard in the preoperative evaluation of complex pulmonary blood supply in patients with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries. In neonates, balloon occlusion aortography using a Berman balloon catheter is a very effective technique. H...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0634-9
更新日期：2004-09-01 00:00:00
abstract：:Pediatric cardiothoracic surgery is often associated with low cardiac output in the postoperative period. This study sought to determine whether increasing heart rate via temporary atrial pacing is beneficial in augmenting cardiac output. Patients younger than 18 years who underwent cardiothoracic surgery and had no p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0687-3
更新日期：2013-10-01 00:00:00
abstract：:Renovascular hypertension is an uncommon disease, but it causes 5-10% of all childhood hypertension. The most common cause of renal artery stenosis is fibromuscular dysplasia, resulting in at least 60% of renovascular hypertension cases. This report describes a case of a renal artery stenosis confirmed by multidetecto...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9944-5
更新日期：2011-06-01 00:00:00
abstract：:That apoptosis is mediated by specific pathways has long been established. However, more recent data have begun to suggest that necrosis may in fact be "programmed" and not a default "accidental" pathway as previously thought. The mitochondrial permeability transition pore, a known contributor to the development of ma...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-010-9880-9
更新日期：2011-03-01 00:00:00
abstract：:The objective of this study was to evaluate the incidence of pre-existing catheterization left pulmonary artery (LPA) gradients and correlation of these gradients with later LPA stenosis after successful patent ductus arteriosus (PDA) occlusion. We performed a single-center review of 130 patients with PDA closure from...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-009-9448-8
更新日期：2009-10-01 00:00:00
abstract：:Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02238841
更新日期：1990-07-01 00:00:00
abstract：:Accessory atrioventricular pathways (AP) are the most common substrate for paroxysmal supraventricular tachycardia in infants and small children. Up-to-date data on AP ablation in infants and small children are limited. The aim of the present study was to gain additional insight into radiofrequency (RF) catheter ablat...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1365-z
更新日期：2016-06-01 00:00:00
abstract：:We sought to describe the use and outcomes of small, medium and large premounted stents in patients with congenital heart disease, including incidence of and risk factors for re-intervention and development of in-stent stenosis. Premounted stents offer several advantages over traditional manually crimped bare-metal st...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1466-8
更新日期：2016-12-01 00:00:00
abstract：:To examine factors associated with low high-density lipoprotein cholesterol (HDL-C) levels among middle school children. HDL-C levels were the primary outcome of interest. A total of 1,104 middle-school children (mean age 11.6 years, 51.2% female) were included in this analysis, of whom 177 (16%) had an HDL-C level ≤4...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-013-0814-1
更新日期：2014-03-01 00:00:00
abstract：:Electrocardiograms (heart rate, QRS voltage, QRS axis in the frontal plane. Q-Tc interval) echocardiograms [left ventricular fractional shortening (LVFS); preejection period (PEP); PEP/left ventricular ejection time (PEP/LVET) ratio; end-diastolic left ventricular free wall and interventricular septum thickness; prese...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02238495
更新日期：1991-01-01 00:00:00
abstract：:Fetal atrioventricular dissociation is a dysrhythmia associated with significant antenatal and postnatal morbidity and mortality. We present a case of a 19-week-old fetus with atrioventricular dissociation, which spontaneously resolved. The mother had no signs of autoimmune disease. The fetus had an uneventful gestati...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900366
更新日期：1998-11-01 00:00:00
abstract：:To assess the prevalence, history, and treatment of arrhythmias, in particular preexcitation and Wolff-Parkinson-White (WPW) syndrome, in patients with Ebstein anomaly (EA) during childhood and adolescence, we performed a multicenter retrospective study of all consecutive live-born patients with EA, diagnosed, and fol...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-009-9590-3
更新日期：2010-02-01 00:00:00
abstract：:During the development of so-called aneurysmal transformation of perimembranous ventricular septal defects (pmVSD), tricuspid valve (TV) morphology and function may be altered resulting in left ventricular (LV) to right atrial (RA) shunting. The feasibility and outcome of interventional closure of these pmVSD has not ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1170-0
更新日期：2015-10-01 00:00:00
abstract：:A case report of a neonate with cardiac tumors in association with tuberous sclerosis is presented. The rare complication of pulmonary embolism and its successful treatment by anticoagulation and thrombolytic therapy is described. The treatment of these cardiac tumors is conservative, because the tumors regress sponta...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010247
更新日期：2001-07-01 00:00:00
abstract：:Myocardial contractility and relaxation are highly dependent on calcium homeostasis. Immature myocardium, as in pediatric patients, is thought to be more dependent on extracellular calcium for optimal function. For this reason, intravenous calcium chloride infusions may improve myocardial function in the pediatric pat...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1322-2
更新日期：2016-03-01 00:00:00
abstract：:The outcome of children born with cyanotic congenital heart disease has markedly improved over the years. Follow up is recommended for most post-operated cases as complications may occur over long term. One of the complications is the development of ventricular dysfunction, often seen after a successful Fontan surgery...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0531-1
更新日期：2013-04-01 00:00:00
abstract：:Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 2...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1532-2
更新日期：2017-02-01 00:00:00
abstract：:Modifications of the Fontan operation can afford excellent palliation for many patients with a variety of forms of single ventricle. In properly selected patients who are good candidates, early and late survival can be as high as 95-97%. However, mortality is considerably higher for patients with risk factors for poor...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-007-9003-4
更新日期：2007-11-01 00:00:00
abstract：:Identification of heart transplant recipients at highest risk for a poor outcome could lead to improved posttransplantation survival. A chart review of primary heart transplantations from 1993 to 2006 was performed. Analysis was performed to evaluate the risk of graft loss for those with a transplantation age less tha...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0077-7
更新日期：2012-01-01 00:00:00
abstract：:The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02449-1
更新日期：2020-11-21 00:00:00
abstract：:As a transcription factor mainly expressed in cardiovascular system, T-box 20 (TBX20) plays an important role in embryonic cardiovascular system development and adult heart function. Previous studies have identified associations of two SNPs in the T-box DNA-binding domain of TBX20 with congenital heart disease (CHD) i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-1073-5
更新日期：2015-04-01 00:00:00
