Cardiac regeneration in children.

Abstract:

:Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising from the pulmonary artery or in children with univentricular hearts, who present enormous morphological changes after volume unloading. In addition, the enormous regenerative potential of growing children's hearts is reflected in the spontaneous courses of children with severely deteriorated cardiac function (e.g., patients with dilated cardiomyopathy). The extent of this regenerative capacity and its time dependency remain to be elucidated in the future and should be exploited to improve the treatment of children with severe heart insufficiency.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Rupp S,Schranz D

doi

10.1007/s00246-015-1120-x

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

713-8

issue

4

eissn

0172-0643

issn

1432-1971

journal_volume

36

pub_type

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