Abstract:
:Very young mammals have an impressive cardiac regeneration capacity. In contrast, cardiac regeneration is very limited in adult humans. The hearts of young children have a higher regenerative capacity compared with adults, as, for example, seen after surgical correction of an anomalous left coronary artery arising from the pulmonary artery or in children with univentricular hearts, who present enormous morphological changes after volume unloading. In addition, the enormous regenerative potential of growing children's hearts is reflected in the spontaneous courses of children with severely deteriorated cardiac function (e.g., patients with dilated cardiomyopathy). The extent of this regenerative capacity and its time dependency remain to be elucidated in the future and should be exploited to improve the treatment of children with severe heart insufficiency.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Rupp S,Schranz Ddoi
10.1007/s00246-015-1120-xsubject
Has Abstractpub_date
2015-04-01 00:00:00pages
713-8issue
4eissn
0172-0643issn
1432-1971journal_volume
36pub_type
杂志文章,评审abstract::Noninvasive Doppler-derived cardiac output was measured with the pulsed Doppler method in 22 healthy newborns during their first four days of life. Maximal blood flow velocity in the aorta was measured with the Doppler ultrasound method. The mean Doppler-derived cardiac output was 273 +/- 59 ml/min/kg. Ductal left-to-...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02083704
更新日期:1988-01-01 00:00:00
abstract::Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1750-2
更新日期:2018-02-01 00:00:00
abstract::Congenital heart defect (CHD) represents the most prevalent birth defect, and accounts for substantial morbidity and mortality in humans. Aggregating evidence demonstrates the genetic basis for CHD. However, CHD is a heterogeneous disease, and the genetic determinants underlying CHD in most patients remain unknown. In...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1822-y
更新日期:2018-04-01 00:00:00
abstract::Two cases of arrhythmogenic right ventricular dysplasia (ARVD) in siblings are reported. In the boy, 14 years old, the clinical history, ECG, echocardiography, and histopathological findings were consistent with ARVD. Premature ventricular contractions of left bundle branch block (LBBB) pattern were recorded but no ve...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02239576
更新日期:1990-04-01 00:00:00
abstract::We report our findings in the microscopic examination of the conduction system in four infants with glycogen storage disease, one of whom had adequate electrophysiologic studies. The electrophysiologic studies in the latter case showed P-A and A-H intervals at the lower limits of normal, but the H-V interval was just ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02265613
更新日期:1982-01-01 00:00:00
abstract::Three cases of criss-cross heart with severe and complex congenital defects are reported. Precise preoperative diagnosis of the morphologic abnormalities made it possible to choose an optimal method of surgical treatment: all patients successfully underwent a Fontan-type surgical procedure. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02239574
更新日期:1990-04-01 00:00:00
abstract::The morphology and natural history of anomalous right ventricular muscle bundles (ARVMB) have been described in a number of postnatal studies. Whether this is a congenital or acquired cardiac lesion remains obscure. A fetal echocardiogram performed in a 32-week gestation mother showed a large ventricular septal defect...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF00795736
更新日期:1994-09-01 00:00:00
abstract::Aortopulmonary window coexisting with tetralogy of Fallot (TF) was prospectively diagnosed by two-dimensional (2D) echocardiography and Doppler in an 18-month-old boy; the diagnosis was confirmed by cardiac catheterization and angiocardiography. Surgical correction was performed, but the patient died in the operating ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02239546
更新日期:1990-01-01 00:00:00
abstract::A blood pump specifically designed to augment flow from the great veins through the lungs would ameliorate the poor physiology of the failing univentricular circulation and result in a paradigm shift in the treatment strategy for Fontan patients. This study is the first to examine mechanical cavopulmonary assistance w...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0649-9
更新日期:2013-08-01 00:00:00
abstract::Patency of the ductus arteriosus (PDA) is a common finding in small premature infants. Recently pulsed-Doppler-cross sectional echocardiography (PD-CSE) has been successfully used in these patients. We report a case of a premature infant with an unusual PD-CSE pattern. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02279882
更新日期:1988-01-01 00:00:00
abstract::Mid-cavity obstruction of the systemic venous atrium developed after the Mustard operation in a child with transposition of the great arteries. Balloon dilatation (BD) was performed twice, to a maximum theoretical transverse diameter of 18 mm. Each time obstruction was initially relieved, but recurred within months. T...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02076341
更新日期:1983-04-01 00:00:00
abstract::Current guidelines recommend that all neonates with Down syndrome (DS) be screened for congenital heart disease (CHD) with an echocardiogram. We sought to determine the effectiveness of a more accessible and less expensive screening strategy consisting of physical examination, electrocardiogram (ECG), and chest X-ray....
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-016-1419-2
更新日期:2016-10-01 00:00:00
abstract::Cardiac intervention remains controversial in patients with trisomy 13 and 18 and little is known about factors that may affect outcomes. The goal of this study was to evaluate preoperative factors and surgical approach with respect to outcomes in these patients. Patients with congenital heart disease and trisomy 13 o...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1738-y
更新日期:2018-01-01 00:00:00
abstract::The case is described of a 14-year-old boy who had a hepatoma with a right atrial extension. He presented with edema, abdominal pain, and ascites. Two-dimensional echocardiography showed a right atrial tumor that had invaded from the inferior vena cava as an extension into the right atrium of the hepatoma. ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02083301
更新日期:1989-10-01 00:00:00
abstract::Our purpose was to evaluate the impact of suspicion or confirmation of heart disease on the physical and psychosocial health of children. We utilized the Child Health Questionnaire (CHQ PF-50). Children ages 5 to 18 years attending a general cardiology clinic were eligible. Those with primary noncardiac diagnoses unre...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0348-z
更新日期:2004-01-01 00:00:00
abstract::This report aims to summarize and evaluate the efficacy and experience of reintervention for children with postoperative pulmonary venous restenosis. Clinical data from 61 patients with postoperative pulmonary venous restenosis who underwent reintervention at Shanghai Children's Medical Center (SCMC) from September 20...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02098-z
更新日期:2019-06-01 00:00:00
abstract::A rare form of endocardial cushion defect is an atrioventricular (AV) canal-type ventricular septal defect with cleft mitral valve in the absence of a primum atrial septal defect. In two infants with Down's syndrome, preoperative delineation of this entity was accomplished. M-mode echocardiographic features included p...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02426975
更新日期:1982-01-01 00:00:00
abstract::Horseshoe lung is a rare malformation that is often associated with lung hypoplasia and/or vascular anomalies. We describe a 10-year-old girl with horseshoe lung and unique left pulmonary vein. This is the first reported case with this vascular feature. The patient presented with signs and symptoms of severe pulmonary...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9735-4
更新日期:2010-08-01 00:00:00
abstract::The reported prenatal detection rates (PDRs) for significant congenital heart disease (sCHD) have been suboptimal, even in the current era. Changes in prenatal ultrasound policy and training may lead to improved prenatal detection of sCHD. This study analyzed the results of a policy to assess fetal cardiac outflow tra...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0526-y
更新日期:2013-03-01 00:00:00
abstract::The aim of the study is to identify reliable quantitative fetal echocardiographic predictors for postnatal development of coarctation (CoA). In this retrospective study, we included 65 fetuses with a prenatally suspected, isolated CoA, born 2010-2018. Dimensions of the cardiac structures, aortic, and ductal arches exp...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02509-6
更新日期:2020-12-23 00:00:00
abstract::The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02513-w
更新日期:2021-01-04 00:00:00
abstract::The longer survival of patients with Duchenne muscular dystrophy due to advances in clinical care has increased the incidence of Duchenne muscular dystrophy-associated cardiomyopathy, a nearly consistent feature in the third decade of life. A 26-year-old patient with Duchenne muscular dystrophy experienced severe acut...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02072-9
更新日期:2019-03-01 00:00:00
abstract::Congenital aneurysms of the thoracic venous system are rare. In particular, innominate venous aneurysms are extremely rare. We describe a 16-year-old girl whose chest x-ray suggested a mediastinal tumor. Three-dimensional contrast-enhancement magnetic resonance venography showed a giant sacciform aneurysm of the left ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0499-y
更新日期:2004-07-01 00:00:00
abstract::Device closure of atrial septal defects (ASDs) is rapidly becoming routine in children. Comparisons are often made to older surgical series with higher morbidities. However outcomes including reintervention, late failure, and the need for long-term follow-up must be considered and compared to those of a current surgic...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-002-0131-6
更新日期:2003-09-01 00:00:00
abstract::Avoidance of red blood cell (RBC) transfusions in patients awaiting heart transplantation (HTx) has been suggested to minimize the risk of allosensitization. Although recent studies have suggested that an immature immune system in younger HTx recipients may reduce risks associated with RBC transfusion, the role of age...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-1814-y
更新日期:2018-04-01 00:00:00
abstract::This study is presented to identify and characterize the spectrum of the cardiovascular anomalies in children presenting with Williams-Beuren syndrome and cardiovascular anomalies at The Hospital for Sick Children, Toronto from 1966 to 1988. Forty-nine children were diagnosed and followed. The female to male ratio was...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02310569
更新日期:1991-10-01 00:00:00
abstract::A 5-year-old boy born with a congenital heart defect had insertion of an epicardial pacemaker that was found on routine evaluation to have been displaced into the rectovesical pouch. He underwent transvenous insertion of another pacemaker, and the displaced pacemaker was successfully retrieved by laparoscopy without i...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-9972-1
更新日期:2011-12-01 00:00:00
abstract::Our objective was to understand the scope of pediatric heart failure (HF) and the current staffing environment of HF programs. An online survey was distributed to members of the Pediatric Heart Transplant Study and the Pediatric Council of the International Society for Heart and Lung Transplantation. All participants ...
journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00246-017-1756-9
更新日期:2018-02-01 00:00:00
abstract::The nuclear cross-sectional area of the muscular fibers from a series of myocardial bridges was analyzed and compared to both the adjacent and underlying myocardial fibers. The series came from 12 hearts of children, ranging in age from 24 h to 2 years, with diverse forms of congenital heart disease, which caused left...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02238364
更新日期:1990-10-01 00:00:00
abstract::Home international normalized ratio (INR) monitors are being increasingly used for monitoring the adequacy of anticoagulation in children on long-term warfarin. Their safety and effectiveness in the home setting has not been fully established. The purpose of this study was to explore the safety and effectiveness of ho...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9535-x
更新日期:2010-01-01 00:00:00