Network hubs in the human brain.

Abstract:

:Virtually all domains of cognitive function require the integration of distributed neural activity. Network analysis of human brain connectivity has consistently identified sets of regions that are critically important for enabling efficient neuronal signaling and communication. The central embedding of these candidate 'brain hubs' in anatomical networks supports their diverse functional roles across a broad range of cognitive tasks and widespread dynamic coupling within and across functional networks. The high level of centrality of brain hubs also renders them points of vulnerability that are susceptible to disconnection and dysfunction in brain disorders. Combining data from numerous empirical and computational studies, network approaches strongly suggest that brain hubs play important roles in information integration underpinning numerous aspects of complex cognitive function.

journal_name

Trends Cogn Sci

authors

van den Heuvel MP,Sporns O

doi

10.1016/j.tics.2013.09.012

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

683-96

issue

12

eissn

1364-6613

issn

1879-307X

pii

S1364-6613(13)00216-7

journal_volume

17

pub_type

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