DNA methylation of MAPK signal-inhibiting genes in papillary thyroid carcinoma.

abstract：:The recombinant plasmid pBHIV-1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the reported chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants were obtained which were resistant to genetecin and expressed ...

journal_title：Anticancer research

authors： Zoumpourlis V,Eliopoulos AG,Spandidos DA

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:HER-2/neu onco-protein is increasingly being recognized as a target for therapy in solid tumors, but data on its role in malignant melanoma is currently limited. Our study objective was to determine a relationship, if any, between HER-2/neu overexpression and malignant melanoma. PATIENTS AND METHODS:Overexp...

journal_title：Anticancer research

authors： Potti A,Hille R,Koch M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIM:The efficacy of omega-3 supplementation by oral capsule for patients with Crohn's disease (CD) remains controversial. We investigated the safety and efficacy of an omega-3 emulsified formulation. PATIENTS AND METHODS:Six patients with CD in remission participated in this open-label clinical trial. Patie...

journal_title：Anticancer research

authors： Yasueda A,Shinzaki S,Iijima H,Mizushima T,Nishimura J,Hiyama S,Ohno S,Ito T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Doxorubicin remains one of the few drugs with consistent single agent activity in advanced Soft Tissue Sarcomas (STS), with a demonstrated dose-response relationship. Liposomal-encapsulated Doxorubicin (LED) has been shown to be at least as active as free doxorubicin in experimental models, and phase I and I...

journal_title：Anticancer research

authors： Toma S,Tucci A,Villani G,Carteni G,Spadini N,Palumbo R

更新日期：2000-01-01 00:00:00

abstract：:To determine the changes in biological features of the prostate during the course of local recurrence of prostate cancer after endocrine therapy, histologic grade, proliferating activity and apoptotic indices were examined in prostate specimens obtained before treatment and at recurrence. A total of 16 patients, who h...

journal_title：Anticancer research

authors： Kaibuchi T,Furuya Y,Akakura K,Masai M,Ito H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Tumor budding and a proficient mismatch repair (pMMR) status are considered adverse prognostic factors in colorectal cancer (CRC). The aim of this pilot study was to assess tumor budding in primary CRC with pMMR versus that with deficient mismatch repair (dMMR). MATERIALS AND METHODS:Tumor budding was retro...

journal_title：Anticancer research

authors： Karlberg M,Stenstedt K,Hallström M,Ragnhammar P,Lenander C,Edler D

更新日期：2018-08-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major clinical obstacle in the treatment of several cancers including hematological malignancies and solid tumors. The ATP-binding cassette transporter B1 (ABCB1) gene and its product, P-glycoprotein (P-gp), is one molecule that is involved in drug resistance. Here we report on the effe...

journal_title：Anticancer research

authors： Onda K,Suzuki R,Tanaka S,Oga H,Oka K,Hirano T

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND/AIM:Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). PATIENTS AND METHODS:GLI1 expression l...

journal_title：Anticancer research

authors： Hashimoto I,Oue N,Kimura Y,Hiroshima Y,Hara K,Maezawa Y,Kano K,Fujikawa H,Aoyama T,Numata M,Yamada T,Tamagawa H,Yamamoto N,Ogata T,Shiozawa M,Morinaga S,Rino Y,Yasui W,Masuda M,Miyagi Y,Oshima T

更新日期：2020-10-01 00:00:00

abstract：:The multistep nature of cancer suggested from chemical carcinogenesis studies, epidemiological data and cell culture experiments could be explained by the occurrence of somatic mutations resulting in inappropriate expression of normal cellular sequences which have an intrinsic potential of becoming cancer genes. The d...

journal_title：Anticancer research

authors： Spandidos DA

更新日期：1983-03-01 00:00:00

abstract：PURPOSE:Effectiveness of a new device inserted within the common cellulose acetate cigarette filter (named hypobaric chamber tar-removing system, HCTRS) to remove tar and its carcinogenic compounds from mainstream cigarette smoke (MCS). METHODS:Eighty HCTRS prototypes were mounted inside the cellulose acetate filter o...

journal_title：Anticancer research

authors： Lazzarino G,Tavazzi B,Sinibaldi-Vallebona P,Di Pierro D,Rasi G

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Chemotherapeutic anticancer properties are thought to derive from apoptosis pathway activation and/or cell division arrest, but animal models have also evidenced anti-angiogenic activity in some agents. PATIENTS AND METHODS:The impact of gemcitabine, irinotecan and oxaliplatin + 5-FU upon the serum markers ...

journal_title：Anticancer research

authors： Bellone G,Novarino A,Chiappino I,Gramigni C,Carbone A,Addeo A,Tonel E,Bertetto O,Emanuelli G

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. ...

journal_title：Anticancer research

authors： Kondo Y,Fukuyama T,Yamamura R,Futawatari N,Ichiki Y,Tanaka Y,Nishi Y,Takahashi Y,Yamazaki H,Kobayashi N,Watanabe M

更新日期：2018-10-01 00:00:00

abstract：:CD62L is the human homologue of the murine lymphocyte homing receptor, mel-14. We investigated CD62L + cells in the spleen from patients with gastric cancer. Flow cytometric analysis revealed that CD62L + cells were decreased in the peripheral blood, but inversely increased in the spleen in parallel with disease progr...

journal_title：Anticancer research

authors： Noma K,Yamaguchi Y,Okita R,Matsuura K,Toge T

更新日期：2005-01-01 00:00:00

abstract：:The stems of Bougainvillea spectabillis Wild (Nyctaginaceae) have been used in folk medicine for hepatis, and spinasterol and quercetin were isolated and characterized from the plant leaves in this study. These constituents have not been previously isolated from Bougainvillea spectabillis W. Quercetin, the flavonoid, ...

journal_title：Anticancer research

authors： Chang WS,Lee YJ,Lu FJ,Chiang HC

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilita...

journal_title：Anticancer research

authors： Kölbl AC,Wellens R,Koch J,Rack B,Hutter S,Friese K,Jeschke U,Andergassen U

更新日期：2016-06-01 00:00:00

abstract：:The effects of supplemental selenium on 7,12-dimethylbenz(a)anthracene (DMBA)-induced and murine mammary tumor virus (MuMTV)-induced mammary tumorigenesis were investigated in BALB/c mice. Selenium (4-10 ppm), administered in the drinking water, inhibited mammary tumor formation in DMBA-treated mice. The higher doses ...

journal_title：Anticancer research

authors： Medina D,Lane H,Shepherd F

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines. CASE REPORT:We administered the patient clonazepam. After taking clonazepam, the patient...

journal_title：Anticancer research

authors： Koga M,Nakadozono M,Nukariya K,Nogi H,Kobayashi T,Nakayama K

更新日期：2008-07-01 00:00:00

abstract：:Major drawbacks to present-day cancer chemotherapy are its intrinsic lack of selectivity for tumour cells, resulting in severe damage to normal rapidly dividing cells, and the widespread emergence of drug resistance. Here experimental evidence is presented demonstrating that PB-100, a beta-carboline alkaloid, selectiv...

journal_title：Anticancer research

authors： Beljanski M,Crochet S,Beljanski MS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Warthin-like mucoepidermoid carcinoma is a newly recognized rare entity and could be misdiagnosed as a benign Warthin tumor. We report such a case of a 36-year-old male who presented with a left parotid gland mass. CASE REPORT:Fine-needle aspiration showed features suggestive of Warthin tumor. Following par...

journal_title：Anticancer research

authors： Zhang D,Liao X,Tang Y,Meyer RG,VAN Dyke DL,Liu X,Islam MN,Lai J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The prognostic significance of mutant p53 protein, p-glycoprotein (P-gp) and glutathione S-transferase-pi (GST-pi) in patients with unresectable non-small cell lung cancer (NSCLC) has not been established. MATERIALS AND METHODS:We performed immunohistochemical staining of p53, P-gp and GST-pi using transbro...

journal_title：Anticancer research

authors： Miyatake K,Gemba K,Ueoka H,Nishii K,Kiura K,Tabata M,Shibayama T,Takigawa N,Kawaraya M,Tanimoto M

更新日期：2003-05-01 00:00:00

abstract：:Four heart hormones, namely atrial natriuretic peptide (ANP), long-acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide reduce up to 97% of cancer cells in vitro. These four cardiac hormones eliminate up to 80% of human pancreatic adenocarcinomas, two-thirds of human breast carcinomas and up to 86%...

journal_title：Anticancer research

authors： Vesely DL

更新日期：2016-11-01 00:00:00

abstract：:We investigated the in vitro effects of heparin on the growth and interaction of SW480 colon adenocarcinoma cells with the extracellular matrix proteins laminin, fibronectin and collagen IV. Cell adhesion assays were performed in wells precoated with the proteins mentioned. Tumor cell migration and invasiveness were a...

journal_title：Anticancer research

authors： Antachopoulos CT,Iliopoulos DC,Gagos S,Agapitos MV,Karayannacos PE,Roboli SK,Skalkeas GD

更新日期：1995-07-01 00:00:00

abstract：UNLABELLED:Reduced serum-zinc concentrations are well known as typical laboratory characteristics in advanced head and neck cancer. Our aim was to follow the development of this phenomenon during the disease. PATIENTS AND METHODS:A total of 21 patients were included in this pilot-study (1 female, 20 male). The median ...

journal_title：Anticancer research

authors： Büntzel J,Bruns F,Glatzel M,Garayev A,Mücke R,Kisters K,Schäfer U,Schönekaes K,Micke O

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-s...

journal_title：Anticancer research

authors： Shackelford RE,Abdulsattar J,Wei EX,Cotelingam J,Coppola D,Herrera GA

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The safety and advantages of perioperative autologous blood transfusion (ABT) were evaluated on hepatectomy for hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Blood samples were obtained and stored from 30 patients with HCC. HCC cells were investigated by the presence of AFPmRNA using RT-PCR after st...

journal_title：Anticancer research

authors： Kitagawa K,Taniguchi H,Mugitani T,Koh T,Obayashi T,Kunishima S,Yamaguchi A,Yamagishi H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Most patients with lung cancer experience relapse, although epidermal growth factor receptor (EGFR) of tyrosine kinase inhibitor (TKI) has an astounding effect on tumors with EGFR-activating mutations. It is therefore critical to determine the mechanisms of resistance against agents and the prognostic value ...

journal_title：Anticancer research

authors： Uramoto H,Yamada T,Yano S,Kondo N,Hasegawa S,Tanaka F

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND/AIM:Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prog...

journal_title：Anticancer research

authors： Izumi K,Shigehara K,Nohara T,Narimoto K,Kadono Y,Mizokami A

更新日期：2017-10-01 00:00:00

abstract：AIM:Late oral mucosa changes after radiotherapy for head and neck cancer have been poorly studied. This study aimed to determine long-term effects of radiotherapy on oral mucosa using exfoliative oral cytology. PATIENTS AND METHODS:Fifty patients with cancer were enrolled, five of whom in order to validate microscopic...

journal_title：Anticancer research

authors： Massaro P,Corbella F,DI Liberto R,Paolini A,Pasi F,Tinelli C,DE Silvestri A,Nano R

更新日期：2014-02-01 00:00:00

abstract：:Several anti-cancer drugs are known to have proliferation-related effects on various cells, such as an activation of some transcription factors and an induction of some cytokines. We examined the effect of anti-cancer drugs on granulocyte-macrophage colony stimulating factor (GM-CSF) induction in human peripheral bloo...

journal_title：Anticancer research

authors： Ogura K,Ohta S,Ohmori T,Takeuchi H,Hirose T,Horichi N,Okuda K,Ike M,Ozawa T,Siba K,Kasahara K,Sasaki Y,Nakajima H,Adachi M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:A double blind placebo RCT of adjuvant treatment of the matrix metalloproteinase inhibitor, Marimastat, in patients with unresectable colorectal liver metastases showed no significant effect on survival. There was a statistically significant survival advantage for the marimastat-treated patients with musculo...

journal_title：Anticancer research

authors： King J,Zhao J,Clingan P,Morris D

更新日期：2003-01-01 00:00:00