Abnormal RNA synthesis in sex vesicles of tertiary trisomic male mice.

Abstract:

:The XY bivalent contained within the sex vesicle of chromosomally normal male mice shows virtually no RNA transcriptional activity as measured by autoradiography during the prophase of meiosis. Tertiary trisomic males, derived from the T 70 H and T 31 H reciprocal translocations, include the extra small marker chromosome to varying degrees within the sex vesicle. It has been found that RNA transcription occurs within the sex vesicles of such trisomics. An attempt has been made to correlate such activity either to the extra marker chromosome itself or to a possible reactivation of the normally quiescent sex bivalent. The relationship of the abnormal RNA synthesis to the breakdown of meiosis in tertiary trisomics and to their subsequent reduced fertility is discussed.

journal_name

Chromosoma

journal_title

Chromosoma

authors

Speed RM

doi

10.1007/BF00292748

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

267-70

issue

3

eissn

0009-5915

issn

1432-0886

journal_volume

93

pub_type

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