Abstract:
:The XY bivalent contained within the sex vesicle of chromosomally normal male mice shows virtually no RNA transcriptional activity as measured by autoradiography during the prophase of meiosis. Tertiary trisomic males, derived from the T 70 H and T 31 H reciprocal translocations, include the extra small marker chromosome to varying degrees within the sex vesicle. It has been found that RNA transcription occurs within the sex vesicles of such trisomics. An attempt has been made to correlate such activity either to the extra marker chromosome itself or to a possible reactivation of the normally quiescent sex bivalent. The relationship of the abnormal RNA synthesis to the breakdown of meiosis in tertiary trisomics and to their subsequent reduced fertility is discussed.
journal_name
Chromosomajournal_title
Chromosomaauthors
Speed RMdoi
10.1007/BF00292748subject
Has Abstractpub_date
1986-01-01 00:00:00pages
267-70issue
3eissn
0009-5915issn
1432-0886journal_volume
93pub_type
杂志文章相关文献
CHROMOSOMA文献大全abstract::Triplet conjugation occurs frequently when three different mating types of T. thermophila are mixed under appropriate conditions. Genetic studies show that fertilization is usually tripolar, with each conjugant contributing a pronucleus to one mate and receiving a pronucleus from the other. Triplets are less common an...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00330410
更新日期:1977-03-07 00:00:00
abstract::In the XY pachytene spermatocyte, the sex chromosomes do not synapse except for the pseudoautosomal region and become transcriptionally silenced. It has been suggested that the meiotic silencing of unsynapsed chromatin (MSUC) also occurs in oocytes. In the XY sex-reversed female mouse, the sex chromosomes fail to pair...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/s00412-013-0415-z
更新日期:2013-10-01 00:00:00
abstract::Nuclear and cytoplasmic RNA of Stylonychia mytilus were analyzed on denaturing polyacrylamide gels. The molecular weight of rRNA precursor molecules is within a range of 2.1 x 10(6) daltons. A comparison between the electrophoretic pattern of nuclear non-ribosomal RNA and cytoplasmic mRNA indicates that a considerable...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00286790
更新日期:1981-01-01 00:00:00
abstract::The 5S RNA gene content of polyploid cells of the ovary of Drosophila melanogaster has been compared in animals with two or three gene clusters. The amount of 5S RNA genes is exactly proportional to the number of gene clusters as determined by DNA-RNA filter hybridization. In contrast, the number of rDNA genes in endo...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00328768
更新日期:1979-01-31 00:00:00
abstract::Saccharomyces cerevisiae cells containing null mutations in the SEP1 gene, which encodes the homologous pairing and strand exchange protein p175SEP1, enter pachytene with a delay. They arrest uniformly at this stage of meiotic prophase, probably revealing a checkpoint in the transition from pachytene to meiosis I. At ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00352322
更新日期:1994-04-01 00:00:00
abstract::Chromosomes were subjected to either prolonged hypotonic solution pretreatment or aging. Both conditions greatly loosened and dispersed the overlying epichromatin from the central chromosome core structure. This was followed by silver staining and examination with bright-field microscopy. The chromosome core selective...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00294845
更新日期:1979-06-21 00:00:00
abstract::DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis, or cancer chemo- or radiotherapy. Cells have developed a vari...
journal_title:Chromosoma
pub_type: 杂志文章,评审
doi:10.1007/s00412-017-0658-1
更新日期:2018-06-01 00:00:00
abstract::With an improved N-banding technique, the location of nucleolar organizing region was determined in 27 kinds of material including mammals, a marsupial, birds, amphibians, fishes, an insect and plants. In most cases the N-bands were clearly located on certain specific regions of chromosomes, such as the secondary cons...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00285128
更新日期:1975-01-01 00:00:00
abstract::Quinacrine (Q-band) and centromeric heterochromatin (C-band) patterns of metaphase chromosomes of two subspecies of Mus musculus were compared. M.m. musculus (the laboratory mouse) and M.m. molossinus (a subspecies from Southeast Asia) had similar Q-band patterns along the length of the chromosomes, but differences we...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00294081
更新日期:1975-12-29 00:00:00
abstract::The large heterochromatic chromosome of Drosophila nasutoides reveals distinctive C- and Q-bands. The regions which are negative in C-banding appear positive in Q-banding. The isochromosomic nature of this chromosome and the locality of the satellite DNAs in this chromosome are discussed with respect to these banding ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00292680
更新日期:1977-04-27 00:00:00
abstract::The mean DNA content of G2 macronuclei varies during the life cycle of the ciliate Tetrahymena thermophila. Early in the life cycle the mean is about 130 C; later it is about 94 C. In hybrids between strains A and B the decrease from 130 C to 94 C usually began after 60 fissions after conjugation. In B X B clones the ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00327377
更新日期:1978-10-20 00:00:00
abstract::Nucleolar matrix structures were obtained under different extraction conditions from highly purified isolated nucleoli. Their ultrastructural appearance, protein composition and capacity to bind rDNA preferentially were studied in a model binding system. A region spanning approximately 25 kb in the rat ribosomal gene ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00352403
更新日期:1993-03-01 00:00:00
abstract::In situ hybridization of labeled DNA of four mobile dispersed genetic elements (mdg), isolated from D. melanogaster and C. virilis genomes, with polytene chromosomes of the larvae of several Drosophila species has been carried out. The data show that the mdg elements exhibit a high degree of species specificity. The s...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00330360
更新日期:1982-01-01 00:00:00
abstract::The DNA coding for 28 S and 18 S ribosomal RNA, including the spacer regions, has been isolated from calf (Bos taurus) thymus gland. The method used included shearing of the total DNA to a highly homogeneous size population, selective heat denaturation and S1 nuclease treatment to remove single stranded DNA. Repeated ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00293439
更新日期:1976-10-12 00:00:00
abstract::Experiments were designed to test whether nonrandom segregation of sister chromatids at mitosis has a role in the production of cell diversity during embryogenesis, Segregation was examined in vivo in retinal cells from embryonic chicks. Chromatids were labelled with bromouracil and stained by the fluorescence plus Gi...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00288461
更新日期:1977-03-16 00:00:00
abstract::BrdU-substituted Chinese hamster chromosomes were treated with a hog Na2HPO4 solution and stained with Giemsa to produce sister chromatid differential staining (SCD). The process of SCD was examined with the Nomarski differential interference microscope and the scanning electron microscope. After the Na2HPO4 treatment...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00285754
更新日期:1981-01-01 00:00:00
abstract::Cyclins, as regulatory partners of cyclin-dependent kinases (CDKs), control the switch-like cell cycle transitions that orchestrate orderly duplication and segregation of genomes. Compared to mitosis, relatively little is known about how cyclin-CDK complexes control meiosis, the specialized cell division that generate...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/s00412-019-00725-5
更新日期:2019-09-01 00:00:00
abstract::The organization of DNA in the mitotic metaphase and polytene chromosomes of the fungus gnat, Sciara coprophila, has been studied using base-specific DNA ligands, including anti-nucleoside antibodies. The DNA of metaphase and polytene chromosomes reacts with AT-specific probes (quinacrine, DAPI, Hoechst 33258 and anti...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00327321
更新日期:1980-01-01 00:00:00
abstract::The eukaryotic genome can be roughly divided into euchromatin and heterochromatin domains that are structurally and functionally distinct. Heterochromatin is characterized by its high compaction that impedes DNA transactions such as gene transcription, replication, or recombination. Beyond its role in regulating DNA a...
journal_title:Chromosoma
pub_type: 杂志文章,评审
doi:10.1007/s00412-015-0545-6
更新日期:2016-06-01 00:00:00
abstract::Chinese hamster cells were grown for 1+ and 2+ cell cycles in the presence of BrdU and then treated by the sister chromatid differential staining technique (SCD). Those regions of a chromosome which had replicated twice in the presence of BrdU were pale staining and by selecting appropriate metaphase cells an accurate...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00364018
更新日期:1975-11-11 00:00:00
abstract::The influence of the sex-reversal factor (Sxr) on X and Y chromosome pairing was examined by comparing males with "novel" and "standard" Sxr genotypes. The novel Sxr males were exceptional in carrying Sxr on their X rather than their Y chromosome, or homozygously on both their X and Y chromosomes, or on a Y chromosome...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00292766
更新日期:1989-03-01 00:00:00
abstract::An unstable minichromosome comprising part of the short arm of chromosome 10 of maize was recovered from an oil yellow variegated plant as a consequence of gamma irradiation of pollen. The cytological and gene dosage observations are consistent with the minichromosome being a partial isochromosome, which lags at mitot...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00352297
更新日期:1996-06-01 00:00:00
abstract::Studies of gene expression in aneuploids have often made the assumption that measurements of RNA abundance from the varied chromosome will establish whether there is a dosage effect or compensation. Typical procedures of RNA isolation and use of equal amounts of RNA for quantitative estimates will not measure the tota...
journal_title:Chromosoma
pub_type: 杂志文章,评审
doi:10.1007/s00412-014-0478-5
更新日期:2014-10-01 00:00:00
abstract::The 17 kDa human autoantigen designated CENP-A is a centromere specific histone. We show here that CENP-A is present in tissue of bovine origin, and that it is quantitatively retained in mature spermatozoa. This result is striking, as a prominent feature of spermatogenesis in mammals is the replacement of most somatic...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00337600
更新日期:1990-12-01 00:00:00
abstract::We describe a method of mapping genes or transcripts on polytene chromosomes by transmission electron microscopy. We present several applications which illustrate that, in favorable cases, the method has a resolution of ca. 10 kg, and that high resolution mapping of hybridization sites relative to bands and puffs can ...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00293158
更新日期:1985-01-01 00:00:00
abstract::Macrosatellites are large polymorphic tandem arrays. The human subtelomeric macrosatellite D4Z4 has 11-150 repeats, each containing a copy of the intronless DUX4 gene. DUX4 is linked to facioscapulohumeral muscular dystrophy, but its normal function is unknown. The DUX gene family includes DUX4, the intronless Dux mac...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/s00412-012-0380-y
更新日期:2012-10-01 00:00:00
abstract::Chromosome replication in the last premeiotic S-phase of male mammals has been previously studied by [3H]thymidine autoradiography and by a 5-bromodeoxyuridine (BrdU)/Giemsa technique. We used a recently developed BrdU-antibody technique (BAT) in this study. The following conclusions were drawn: (1) The replication pa...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00346006
更新日期:1992-03-01 00:00:00
abstract::The Bacillus subtilis phage phi 29 DNA polymerase, involved in protein-primed viral DNA replication, contains several amino acid consensus sequences common to other eukaryotic-type DNA polymerases. Using site-directed mutagenesis, we have studied the functional significance of a C-terminal conserved region, represente...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF02451783
更新日期:1992-01-01 00:00:00
abstract::In 1906, the Spanish neurobiologist Santiago Ramón y Cajal was awarded the Nobel Prize in Physiology or Medicine in recognition of his work on the structure of neurons and their connections. Cajal is commonly regarded as the father of modern neuroscience. What is less well known is that Cajal also had a great interest...
journal_title:Chromosoma
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/s00412-009-0212-x
更新日期:2009-08-01 00:00:00
abstract::Exposure of Nyctotherus ovalis to low temperatures or vinblastine caused similar reactions of "classes" of microtubules (mt) present in the mitotic micronucleus of this ciliate towards both treatments. However, differences of sensitivity between certain "classes" of mt at individual mitotic stages exist. Unlike the ki...
journal_title:Chromosoma
pub_type: 杂志文章
doi:10.1007/BF00330781
更新日期:1982-01-01 00:00:00