Abstract:
:Chromosome replication in the last premeiotic S-phase of male mammals has been previously studied by [3H]thymidine autoradiography and by a 5-bromodeoxyuridine (BrdU)/Giemsa technique. We used a recently developed BrdU-antibody technique (BAT) in this study. The following conclusions were drawn: (1) The replication patterns observed are similar to that of somatic cells. (2) The heterochromatin starts replication in early S-phase. (3) The euchromatic part of the X chromosome of the male Chinese hamster replicates together with the autosomes and therefore behaves isocyclicly and not allocyclicly as hitherto assumed. Hence, genetic inactivity of the X chromosome may be brought about by a mechanism different from that in somatic cells.
journal_name
Chromosomajournal_title
Chromosomaauthors
Latos-Bielenska A,Vogel Wdoi
10.1007/BF00346006subject
Has Abstractpub_date
1992-03-01 00:00:00pages
279-83issue
5-6eissn
0009-5915issn
1432-0886journal_volume
101pub_type
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