The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways.

Abstract:

:Nucleosome assembly involves deposition of a heterotetramer of histones H3/H4 onto DNA followed by two heterodimers of histones H2A/H2B. Cycles of nucleosome assembly and disassembly are essential to cellular events such as replication, transcription, and DNA repair. After synthesis in the cytoplasm, histones are shuttled into the nucleus where they are associated with chaperone proteins. Chaperones of histones H3/H4 include CAF-I, the Hir proteins, and Asf1. CAF-I and the Hir proteins function as replication-coupled and replication-independent deposition factors for H3/H4, respectively, whereas Asf1 may play a role in both pathways. In addition to acting as assembly factors, histone chaperones assist nucleosome dissociation from DNA and they may recruit other proteins to chromatin. The past few years have witnessed a notable accumulation of genetic, biochemical, and structural data on Asf1, which motivated this review. We discuss the sequence and structural features of Asf1 before considering its roles in nucleosome assembly/disassembly, the cellular response to DNA damage, and the regulation of gene expression. We emphasize the key role of Asf1 as a central node in a network of partners that place it at the crossroads of chromatin and DNA checkpoint pathways.

journal_name

Chromosoma

journal_title

Chromosoma

authors

Mousson F,Ochsenbein F,Mann C

doi

10.1007/s00412-006-0087-z

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

79-93

issue

2

eissn

0009-5915

issn

1432-0886

journal_volume

116

pub_type

杂志文章,评审
  • Chromosomal locations of major tRNA gene clusters of Xenopus laevis.

    abstract::In Xenopus laevis eight tRNA genes are located in a 3.18 kb tandemly repeated unit. There are 150 copies of the unit at a single locus near the long arm telomere of one of the acrocentric chromosomes in the 14-17 group. Two additional classes of tRNA gene-containing repeats have been isolated (defined by clones p3.1 a...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00352227

    authors: Narayanswami S,Doering JL,Fokta FJ,Rosenthal DS,Nguyen TN,Hamkalo BA

    更新日期:1995-10-01 00:00:00

  • Molecular structure of chromatin during sperm differentiation of the dogfish Scyliorhinus caniculus (L.).

    abstract::The molecular structure of chromatin during dogfish spermiogenesis was examined by electron microscopy after the dispersion of nuclei at low ionic strength. In early and late stages of differentiation (round and elongating spermatids), chromatin is globular, although basic nuclear proteins are different from those pre...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00292041

    authors: Gusse M,Chevaillier P

    更新日期:1980-01-01 00:00:00

  • BrdU-33258 Hoechst analysis of DNA replication in human lymphocytes with supernumerary or structurally abnormal X chromosomes.

    abstract::BrdU-33258 Hoechst techniques have been used to characterize DNA replication patterns in lymphocytes from hunam females with supernumerary or structurally abnormal X chromosomes. Fluorescence analysis permits identification of late replicating X chromosomes in a very high proportion of cells and affords a high resolut...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00292912

    authors: Latt SA,Willard HF,Gerald PS

    更新日期:1976-08-17 00:00:00

  • Large scale isolation of nuclei and nucleoli from vitellogenic oocytes of Xenopus laevis.

    abstract::A new method is described which allows the purification of large quantities of nuclei (germinal vesicles) from Xenopus laevis vitellogenic oocytes of different developmental stages. From the isolated nuclei, purified nucleoli were obtained. The isolated germinal vesicles are transcriptionally active showing endogenous...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00328531

    authors: Scalenghe F,Buscaglia M,Steinheil C,Crippa M

    更新日期:1978-05-16 00:00:00

  • Chromosome markers in Mus musculus: differences in C-banding between the subspecies M.m. musculus and M.m. molossinus.

    abstract::Quinacrine (Q-band) and centromeric heterochromatin (C-band) patterns of metaphase chromosomes of two subspecies of Mus musculus were compared. M.m. musculus (the laboratory mouse) and M.m. molossinus (a subspecies from Southeast Asia) had similar Q-band patterns along the length of the chromosomes, but differences we...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00294081

    authors: Dev VG,Miller DA,Tantravahi R,Schreck RR,Roderick TH,Erlanger BF,Miller OJ

    更新日期:1975-12-29 00:00:00

  • The centromere composition of multiple repetitive sequences on rice chromosome 5.

    abstract::The large-scale primary structure of the centromeric region of rice chromosome 5 was analyzed, the first example in a cereal species. The yeast artificial chromosome (YAC) and bacterial artificial chromosome (BAC) contigs aligned on the centromere of rice chromosome 5 (CEN5) covered a distance of more than 670 kb. Str...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s004120100148

    authors: Nonomura K,Kurata N

    更新日期:2001-08-01 00:00:00

  • The breakage-fusion-bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma.

    abstract::Osteosarcoma (OS) is characterized by chromosomal instability and high copy number gene amplification. The breakage-fusion-bridge (BFB) cycle is a well-established mechanism of genome instability in tumors and in vitro models used to study the origins of complex chromosomal rearrangements and cancer genome amplificati...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-006-0074-4

    authors: Selvarajah S,Yoshimoto M,Park PC,Maire G,Paderova J,Bayani J,Lim G,Al-Romaih K,Squire JA,Zielenska M

    更新日期:2006-12-01 00:00:00

  • Yeast pre-meiotic DNA replication utilizes mitotic origin ARS1 independently of CDC7 function.

    abstract::In budding yeast, mitotic DNA replication initiates at sequence-specific replication origins, the prototype for which is ARS1. Initiation serves as the primary control point for mitotic DNA replication, and is catalyzed by the Cdc7 protein kinase. In contrast, premeiotic DNA replication apparently does not require Cdc...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00360406

    authors: Hollingsworth RE Jr,Sclafani RA

    更新日期:1993-06-01 00:00:00

  • Molecular characterization of repetitive DNA sequences from a B chromosome.

    abstract::In the parasitic wasp Nasonia vitripennis, certain males carry a B chromosome, called PSR (paternal sex ratio), which causes the compaction and subsequent loss of the paternal chromosomes in fertilized eggs. Because Nasonia are haplo-diploid, this leads to the production of all-male broods. Three families (PSR2, PSR18...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00660317

    authors: Eickbush DG,Eickbush TH,Werren JH

    更新日期:1992-08-01 00:00:00

  • A neocentromere in the DAZ region of the human Y chromosome.

    abstract::We describe a novel rearranged human Y chromosome consisting of an inverted duplication of the long arm heterochromatin and a small amount of euchromatin: rea(Y)(qter-q11.2::q11.2-qter). The normal centromere has been deleted and a neocentromere containing CENP-A, -C, -E and Mad2 but not CENP-B has formed close to the...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s004120000081

    authors: Floridia G,Gimelli G,Zuffardi O,Earnshaw WC,Warburton PE,Tyler-Smith C

    更新日期:2000-01-01 00:00:00

  • Strong conservation of the bird Z chromosome in reptilian genomes is revealed by comparative painting despite 275 million years divergence.

    abstract::The divergence of lineages leading to extant squamate reptiles (lizards, snakes, and amphisbaenians) and birds occurred about 275 million years ago. Birds, unlike squamates, have karyotypes that are typified by the presence of a number of very small chromosomes. Hence, a number of chromosome rearrangements might be ex...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-011-0322-0

    authors: Pokorná M,Giovannotti M,Kratochvíl L,Kasai F,Trifonov VA,O'Brien PC,Caputo V,Olmo E,Ferguson-Smith MA,Rens W

    更新日期:2011-10-01 00:00:00

  • Kinetochore rearrangement in meiosis II requires attachment to the spindle.

    abstract::The distinctive behaviors of chromosomes in mitosis and meiosis depend upon differences in kinetochore position. Kinetochore position is well established except for a critical transition between meiosis I and meiosis II. We examined kinetochore position during the transition and compared it with the position of kineto...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-005-0330-z

    authors: Paliulis LV,Nicklas RB

    更新日期:2005-03-01 00:00:00

  • Arrangement of chromosome ends and axial core formation during early meiotic prophase in the male grasshopper Brachystola magna by 3D, E.M. reconstruction.

    abstract::Evidence is presented that chromosome ends are attached to the nuclear envelope prior to the formation of axial cores during early meiotic prophase in the grasshopper Brachystola magna. The attachment sites of distal and proximal chromosome ends are clustered in a small region of the inner nuclear envelope resulting i...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00292844

    authors: Church K

    更新日期:1976-11-29 00:00:00

  • "Doubled-haploid" allohexaploid Brassica lines lose fertility and viability and accumulate genetic variation due to genomic instability.

    abstract::Microspore culture stimulates immature pollen grains to develop into plants via tissue culture and is used routinely in many crop species to produce "doubled haploids": homozygous, true-breeding lines. However, microspore culture is also often used on material that does not have stable meiosis, such as interspecific h...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-019-00720-w

    authors: Mwathi MW,Schiessl SV,Batley J,Mason AS

    更新日期:2019-12-01 00:00:00

  • Divergence in centromere structure distinguishes related genomes in Coix lacryma-jobi and its wild relative.

    abstract::Knowledge about the composition and structure of centromeres is critical for understanding how centromeres perform their functional roles. Here, we report the sequences of one centromere-associated bacterial artificial chromosome clone from a Coix lacryma-jobi library. Two Ty3/gypsy-class retrotransposons, centromeric...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-009-0239-z

    authors: Han Y,Wang G,Liu Z,Liu J,Yue W,Song R,Zhang X,Jin W

    更新日期:2010-02-01 00:00:00

  • Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153.

    abstract::The vertebrate pore protein Nup153 plays pivotal roles in nuclear pore function. In addition to being important to pore architecture, Nup153 is a key participant in both import and export. The scope of Nup153 function also extends beyond the canonical view of the pore as a trafficking gateway. During the transition in...

    journal_title:Chromosoma

    pub_type: 杂志文章,评审

    doi:10.1007/s00412-005-0019-3

    authors: Ball JR,Ullman KS

    更新日期:2005-11-01 00:00:00

  • Chromosomal homeologies between human, harbor seal (Phoca vitulina) and the putative ancestral carnivore karyotype revealed by Zoo-FISH.

    abstract::We report on the construction of the first comparative Zoo-FISH map of a marine mammal. Zoo-FISH with DNA probes from a human chromosome-specific library to metaphase spreads of the harbor seal (Phoca vitulina) disclosed 31 conserved syntenic segments covering the complete autosomal complement and the X chromosome. Co...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s004120050230

    authors: Frönicke L,Müller-Navia J,Romanakis K,Scherthan H

    更新日期:1997-07-01 00:00:00

  • Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cells.

    abstract::The immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome is a rare autosomal recessive disease. Usually, it is caused by mutations in the DNA methyltransferase 3B gene, which result in decreased methylation of satellite DNA in the juxtacentromeric heterochromatin at 1qh, 16qh, and 9qh. Sat...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-005-0343-7

    authors: Gisselsson D,Shao C,Tuck-Muller CM,Sogorovic S,Pålsson E,Smeets D,Ehrlich M

    更新日期:2005-07-01 00:00:00

  • Mechanisms for sister chromatid exchanges and their relation to the production of chromosomal aberrations.

    abstract::By taking advantage of the fact that fluorescent light (FL) induces strand breaks only in bromodeoxyuridine(BrdUy-substituted DNA, and that those breaks eventually lead to the formation of sister chromatid exchanges (SCEs), the response of SCEs to FL was studied carefully in Chinese hamster chromosomes in which, out o...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00292776

    authors: Kato H

    更新日期:1977-02-03 00:00:00

  • The heat shock genes in the Drosophila montium subgroup: chromosomal localization and evolutionary implications.

    abstract::The hsp70, hsp83, hsromega, and the small heat shock protein genes were mapped on the polytene chromosomes of six species, representative of the geographical distribution of the Drosophila montium subgroup of the melanogaster species group. In addition, based on hybridization conditions, the putative locus of the hsp6...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF02509520

    authors: Drosopoulou E,Konstantopoulou I,Scouras ZG

    更新日期:1996-08-01 00:00:00

  • Replication origin plasticity, Taylor-made: inhibition vs recruitment of origins under conditions of replication stress.

    abstract::Among his many contributions to the field of chromosome structure and dynamics, J. Herbert Taylor showed that eukaryotic cells have many more potential replication origins than they use, which they can recruit when replication forks are slowed to complete S-phase in a timely fashion. Thirty years later, his findings r...

    journal_title:Chromosoma

    pub_type: 杂志文章,评审

    doi:10.1007/s00412-007-0105-9

    authors: Gilbert DM

    更新日期:2007-08-01 00:00:00

  • Frequency and distribution of chiasmata in Syrian hamster spermatocytes studied by the BrdU antibody technique.

    abstract::The frequency and distribution of chiasmata and the nature of terminal "associations" was re-examined in Syrian hamster spermatocytes using the 5-bromo-2'-deoxyuridine (BrdU) antibody technique (BAT) for differential chromatid labelling. Differential chromatid substitution was achieved by BrdU incorporation at the pen...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF01731702

    authors: Latos-Bielenska A,Vogel W

    更新日期:1990-08-01 00:00:00

  • The organization of the evolutionarily conserved GATA/GACA repeats in the mouse genome.

    abstract::Simple repeated GATA and GACA sequences which were originally isolated from sex-specific snake satellite DNA have been found subsequently in all eukaryotes studied. The organization of these sequences within the mouse genome was investigated here by using synthetic oligonucleotide probes as a novel tool in comparison ...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00386791

    authors: Schäfer R,Ali S,Epplen JT

    更新日期:1986-01-01 00:00:00

  • Triplex-forming DNAs in the human interphase nucleus visualized in situ by polypurine/polypyrimidine DNA probes and antitriplex antibodies.

    abstract::The polypurine/polypyrimidine (PuPy) tracts present in the human genome are known to be scattered among and within chromosomes. In PuPy tract sequences, triplex formation occurs readily under physiological conditions, leaving single-stranded DNAs capable of hybridization with complementary single-stranded DNAs and RNA...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-002-0198-0

    authors: Ohno M,Fukagawa T,Lee JS,Ikemura T

    更新日期:2002-09-01 00:00:00

  • Chromosome painting and comparative physical mapping of the sex chromosomes in Populus tomentosa and Populus deltoides.

    abstract::Dioecious species accounted for 6% of all plant species, including a number of crops and economically important species, such as poplar. However, sex determination and sex chromosome evolution have been studied only in few dioecious species. In poplar, the sex-determining locus was mapped to chromosome 19. Interesting...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-018-0664-y

    authors: Xin H,Zhang T,Han Y,Wu Y,Shi J,Xi M,Jiang J

    更新日期:2018-09-01 00:00:00

  • Unique XCI evolution in Tokudaia: initial XCI of the neo-X chromosome in Tokudaia muenninki and function loss of XIST in Tokudaia osimensis.

    abstract::X chromosome inactivation (XCI) is an essential mechanism to compensate gene dosage in mammals. Here, we show that XCI has evolved differently in two species of the genus Tokudaia. The Amami spiny rat, Tokudaia osimensis, has a single X chromosome in males and females (XO/XO). By contrast, the Okinawa spiny rat, Tokud...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/s00412-017-0639-4

    authors: Zushi H,Murata C,Mizushima S,Nishida C,Kuroiwa A

    更新日期:2017-12-01 00:00:00

  • Suppression of quinacrine banding of human chromosomes by mounting in organic media.

    abstract::When A-banded human chromosomes mounted in water are transferred to an organic mounting medium, the chromosomes show uniform bright quinacrine fluorescence. This change is reversible. It is inferred that quinacrine is bound uniformly along the chromosomes, and that Q-banding is a consequence of a non-uniform distribut...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00294941

    authors: Sumner AT

    更新日期:1977-12-06 00:00:00

  • Heterochromatin markers: a search for heterochromatin specific middle repetitive sequences in Drosophila.

    abstract::We sought for cloned sequences of middle repetitive (MR) complexity that mark obligatory heterochromatic regions. Total genome probes were employed in a differential screening procedure to recover X-specific, Y-specific and autosomal specific heterochromatic sequences. X-and Y-linked sequences were recovered in the sa...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00330119

    authors: Lifschytz E,Hareven D

    更新日期:1982-01-01 00:00:00

  • The presence of an antigen reactive with a human autoantibody in Trichosia pubescens (Diptera: Sciaridae) and its association with certain transcriptionally active regions of the genome.

    abstract::The antigens in HeLa and Trichosia pubescens cells, recognized by sera from patients with rheumatic diseases containing anti-Ku antibodies, were compared by means of immunoprecipitation of labeled cell extracts. The autoantibodies present in the tested sera precipitate at least two polypeptides of approximately Mr = 7...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF01735325

    authors: Amabis JM,Amabis DC,Kaburaki J,Stollar BD

    更新日期:1990-04-01 00:00:00

  • Polytene chromosomes of Oxytricha: biochemical and morphological changes during macronuclear development in a ciliated protozoan.

    abstract::After conjugation in the ciliated protozoan, Oxytricha, polytene chromosomes are formed during the development of a macronucleus from a micronucleus. Here we report a microscopic study of these chromosomes and an analysis of their DNA. The polytene chromosomes of Oxytricha bear a strong morphological resemblance to th...

    journal_title:Chromosoma

    pub_type: 杂志文章

    doi:10.1007/BF00331828

    authors: Spear BB,Lauth MR

    更新日期:1976-01-27 00:00:00