Abstract:
:The vertebrate pore protein Nup153 plays pivotal roles in nuclear pore function. In addition to being important to pore architecture, Nup153 is a key participant in both import and export. The scope of Nup153 function also extends beyond the canonical view of the pore as a trafficking gateway. During the transition into mitosis, Nup153 directs proteins involved in membrane remodeling to the nuclear envelope. As cells exit mitosis, Nup153 is recruited to the chromosomal surface, where nuclear pores are formed anew in a complicated process still under much experimental scrutiny. In addition, Nup153 is targeted for protease cleavage during apoptosis and in response to certain viral infections, providing molecular insight into pore reconfiguration during cell response. Overall, the versatile nature of Nup153 underscores an emerging view of the nuclear pore at the nexus of many key cellular processes.
journal_name
Chromosomajournal_title
Chromosomaauthors
Ball JR,Ullman KSdoi
10.1007/s00412-005-0019-3subject
Has Abstractpub_date
2005-11-01 00:00:00pages
319-30issue
5eissn
0009-5915issn
1432-0886journal_volume
114pub_type
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