Metastatic clear-cell hidradenocarcinoma of the vulva.

abstract：OBJECTIVES:Although many clinicians practice empiric dose reduction to prevent toxicity, it is unknown whether obese patients given chemotherapy dosed according to actual body weight (ABW) experience excess toxicity. At our institution, cancer patients receive chemotherapy dosed by ABW unless on a protocol capping dose...

journal_title：Gynecologic oncology

authors： Schwartz J,Toste B,Dizon DS

更新日期：2009-07-01 00:00:00

abstract：:A comprehensive understanding of retroperitoneal lymphatic involvement is lacking in tumors of low malignant potential. This study was undertaken to evaluate retroperitoneal lymphatic involvement in patients with ovarian tumors of low malignant potential. One hundred seventy-one patients were diagnosed with epithelial...

journal_title：Gynecologic oncology

authors： Leake JF,Rader JS,Woodruff JD,Rosenshein NB

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:To construct a tool, using computed tomography (CT) imaging and preoperative clinical variables, to estimate successful primary cytoreduction for advanced epithelial ovarian cancer (EOC). METHODS:Women who underwent primary cytoreductive surgery for stage IIIC/IV EOC at Mayo Clinic between 1/2/2003 and 12/3...

journal_title：Gynecologic oncology

authors： Janco JM,Glaser G,Kim B,McGree ME,Weaver AL,Cliby WA,Dowdy SC,Bakkum-Gamez JN

更新日期：2015-07-01 00:00:00

abstract：:In an attempt to characterize the molecular alterations of cervical adenocarcinoma, we analyzed 32 paraffin-embedded specimens for the presence of K-ras mutations, p53 overexpression, p16 and Rb protein expression, and the presence of HPV 16 and 18 DNA. Overall 25/32 (78%) of the tumors displayed an abnormality in at ...

journal_title：Gynecologic oncology

authors： Parker MF,Arroyo GF,Geradts J,Sabichi AL,Park RC,Taylor RR,Birrer MJ

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Pegylated liposomal doxorubicin (PLD) has similar reported clinical efficacy compared with conventional doxorubicin with less cardiotoxicity. The manufacturer of PLD advises that cardiac function should be evaluated with endomyocardial biopsy, echocardiography or multigated radionucleotide scan (MUGA) pre-tre...

journal_title：Gynecologic oncology

authors： Dioun SM,Vilardo N,Goldberg GL,Gressel GM

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Previous studies have identified loss of chromosomal regions 7p12-q11.2 and 8p12-p21 in choriocarcinoma suggesting that suppressor genes involved in tumour development may be located within these regions. Our objectives were to refine the regions of loss and evaluate these deletions as prognostic indicators ...

journal_title：Gynecologic oncology

authors： Burke B,Sebire NJ,Moss J,Hodges MD,Seckl MJ,Newlands ES,Fisher RA

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:To evaluate reasons for discontinuing intraperitoneal (IP) chemotherapy, and to compare characteristics of patients who did versus did not successfully complete six cycles of IP chemotherapy. METHODS:In a phase III trial, women with optimal stage III ovarian or peritoneal carcinoma were randomly allocated t...

journal_title：Gynecologic oncology

authors： Walker JL,Armstrong DK,Huang HQ,Fowler J,Webster K,Burger RA,Clarke-Pearson D

更新日期：2006-01-01 00:00:00

abstract：:Considerable debate centers on the optimal treatment for vulvar melanoma, as well as those clinicopathological factors influencing prognosis. We reviewed 80 patients with vulvar melanoma seen between 1949 and 1990. Primary tumors were assessed according to Chung (47 patients) and Breslow (65 patients) microstaging sys...

journal_title：Gynecologic oncology

authors： Trimble EL,Lewis JL Jr,Williams LL,Curtin JP,Chapman D,Woodruff JM,Rubin SC,Hoskins WJ

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Herpes gestationis (HG) is a rare, recurrent, pruritic, vesicobullous dermatosis occurring predominantly in pregnancy and seldom in early puerperium. Reports of the association of HG with choriocarcinoma are extremely rare and this case highlights such a possible link. CASE:This case focuses on the late pos...

journal_title：Gynecologic oncology

authors： Djahansouzi S,Nestle-Kraemling C,Dall P,Bender HG,Hanstein B

更新日期：2003-05-01 00:00:00

abstract：:Two cases with squamous cell carcinoma of the cervix stage IIB with primary tumor mass about 2 X 2 X 2 cm were treated with primary chemotherapy of cis-platinum, 20 micrograms/m2 body surface intravenously daily for 5 consecutive days. Papanicolaou smear turned negative after two courses of chemotherapy in both cases....

journal_title：Gynecologic oncology

authors： Kim DS,Moon H,Kang KJ

更新日期：1985-09-01 00:00:00

abstract：:Fourteen patients with refractory or metastatic adenocarcinoma of the endometrium were treated with continuous infusion vinblastine. No patient had a response. One patient had stable disease. Although well tolerated, vinblastine sulfate given by this method has no activity in this malignancy. ...

journal_title：Gynecologic oncology

authors： Kavanagh JJ,Saul PB,Wharton JT,Rutledge FN

更新日期：1987-02-01 00:00:00

abstract：:A number of chemical agents have been found to influence the proliferation, morphology, enzymatic activity, and antigen expression of neoplastic cells toward a more differentiated phenotype. We studied the effects of differentiating agents retinoic acid, sodium butyrate, and dibutyryl cyclic AMP on the expression of t...

journal_title：Gynecologic oncology

authors： Brooks SE,Timmerman J,Lau CC,Tsao SW,Knapp RC,Sheets EE

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to analyze risk factors for septic complications during adjuvant chemotherapy and their impact on survival in patients with advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS:We retrospectively revie...

journal_title：Gynecologic oncology

authors： Son JH,Lee JH,Jung JA,Kong TW,Paek J,Chang SJ,Ryu HS

更新日期：2018-10-01 00:00:00

abstract：:Copyright ...

journal_title：Gynecologic oncology

authors： Wharton JT,Gershenson DM

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:ATP-binding Cassette (ABC) transporters are thought to cause multiple drug resistance (MDR) in various carcinomas. Gene expression data from individual transporters in ovarian cancer tissue is contradictory and also scarce for some of them. RNA levels of a panel of ABC transporters were collected and analyzed...

journal_title：Gynecologic oncology

authors： Auner V,Sehouli J,Oskay-Oezcelik G,Horvat R,Speiser P,Zeillinger R

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to determine if three-dimensional power Doppler ultrasound improves the specificity for ovarian cancer detection as compared with two-dimensional ultrasound. METHODS:Seventy-one women with a known complex pelvic mass were referred for a preoperative ultrasound evaluation with both ...

journal_title：Gynecologic oncology

authors： Cohen LS,Escobar PF,Scharm C,Glimco B,Fishman DA

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between body mass index (BMI), physical activity (PA) and the quality of life (QoL) of ovarian cancer survivors. METHODS:We performed a two-centre cross-sectional study of women who had been treated for ovarian cancer between January 2007 and December 2014 at the Royal Cornwall Ho...

journal_title：Gynecologic oncology

authors： Smits A,Smits E,Lopes A,Das N,Hughes G,Talaat A,Pollard A,Bouwman F,Massuger L,Bekkers R,Galaal K

更新日期：2015-10-01 00:00:00

abstract：:Of a group of 68 patients treated with standard polychemotherapy (CAP-5), 52 were evaluated by an early second-look laparotomy, preferably after three cycles of treatment. Of 21 patients with initial tumor residuals smaller than 2 cm, only 5 had residual tumor, and of 31 patients with tumor larger than 2 cm, 27 had re...

journal_title：Gynecologic oncology

authors： van Lith JM,Bouma J,Aalders JG,Boonstra H,Sleijfer DT,Willemse PH

更新日期：1989-11-01 00:00:00

abstract：:Absorbable synthetic mesh (910-polyglactin) was used to create an intestinal sling in six patients undergoing surgical staging of pelvic malignancies prior to radiation therapy. All patients had effective compartmentalization of small intestine out of the pelvis which persisted throughout the duration of radiation the...

journal_title：Gynecologic oncology

authors： Soper JT,Clarke-Pearson DL,Creasman WT

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVES:Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (Smac) has been described to sensitize for apoptosis. We have explored the proapoptotic activity of a small molecule mimic of Smac/DIABLO on ovarian cancer ...

journal_title：Gynecologic oncology

authors： Petrucci E,Pasquini L,Petronelli A,Saulle E,Mariani G,Riccioni R,Biffoni M,Ferretti G,Benedetti-Panici P,Cognetti F,Scambia G,Humphreys R,Peschle C,Testa U

更新日期：2007-05-01 00:00:00

abstract：:Hypersensitivity reactions to intravenous administration of carboplatin (CP) have been previously reported. However, hypersensitivity reaction to intraperitoneal administration of CP has not yet been reported. A 66-year-old woman diagnosed with ovarian carcinoma underwent six courses of intraperitoneal administration ...

journal_title：Gynecologic oncology

authors： Shukunami K,Kurokawa T,Kawakami Y,Kubo M,Kotsuji F

更新日期：1999-03-01 00:00:00

abstract：:Two patients with a history of stage IB cervical cancer who had undergone prior radical abdominal hysterectomy, omental J-flap placement, and postoperative whole pelvic radiation therapy required subsequent exploratory laparotomy with resection of omental J-flap for treatment of chronic abdominal pain 5 and 2 years, r...

journal_title：Gynecologic oncology

authors： Patsner B

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The efficacy and toxicity of neoadjuvant chemotherapy (NAC) with mitomycin-C, vincristine and cisplatin (MVC) were assessed in bulky cervical carcinoma patients. METHODS:Forty-six patients with stage IB2 to IIB cervical cancer were treated with intravenous combination of mitomycin-C 10 mg/m(2), vincristine 1...

journal_title：Gynecologic oncology

authors： Choi CH,Kim TJ,Lee JW,Kim BG,Lee JH,Bae DS

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Molecular chaperone 78 kDa glucose-regulated protein (GRP78) is a residential protein in the endoplasmic reticulum (ER) that is induced by an unfolded-protein response triggered under many kinds of stress against a cell. GRP78 is also known to act as an anti-apoptotic factor by protecting ER-stress-induced ce...

journal_title：Gynecologic oncology

authors： Luvsandagva B,Nakamura K,Kitahara Y,Aoki H,Murata T,Ikeda S,Minegishi T

更新日期：2012-07-01 00:00:00

abstract：:In situ hybridization (ISH) and polymerase chain reaction (PCR) for several common HPV types were performed on 41 cases of vulvar dystrophy, 19 of which were associated with previous or simultaneous invasive squamous cell carcinoma of the vulva. Three of the 19 cases (16%) of dystrophy associated with cancer were foun...

journal_title：Gynecologic oncology

authors： Sagerman PM,Choi YJ,Hu Y,Niedt GW

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVES:Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage ...

journal_title：Gynecologic oncology

authors： Fader AN,Bergstrom J,Jernigan A,Tanner EJ 3rd,Roche KL,Stone RL,Levinson KL,Ricci S,Wethingon S,Wang TL,Shih IM,Yang B,Zhang G,Armstrong DK,Gaillard S,Michener C,DeBernardo R,Rose PG

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Formation of urinary stones in a continent urostomy (Indiana pouch) has been described as a late complication. Management of a patient with symptomatic multiple large stones and review of the literature are outlined. CASE REPORT:A 32-year-old woman presented with recurrent urinary tract infections and pyelo...

journal_title：Gynecologic oncology

authors： Sait K,Stuart G,Nation J,Ghatage P

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:This article critically reviews the literature on the association between endometriosis and gynecological cancers and breast cancer, based on epidemiologic data. METHODS:Literature review of the English language literature based on searching in the MEDLINE (PubMed) database and additional collection of repor...

journal_title：Gynecologic oncology

authors： Munksgaard PS,Blaakaer J

更新日期：2011-10-01 00:00:00

abstract：:A case of Stage IV endometrial squamous cell carcinoma occurring 8 years after a low anterior resection and whole pelvic radiation therapy for a Dukes D colon carcinoma is presented. Koilocytosis was present in the tumor. There was no evidence of human papillomavirus antigen or DNA in the tumor. The patient was treate...

journal_title：Gynecologic oncology

authors： Sorosky JI,Kaminski PF,Kreider J,Podczaski ES,Olt GJ,Zaino R

更新日期：1995-06-01 00:00:00

abstract：:Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Cisplatin-based combination chemotherapy, the most commonly used cytotoxic therapy, has produced response rates ranging from 20% to 30% and overall survival of less than 10 months. Because of the minimal degree of success with ...

journal_title：Gynecologic oncology

authors： del Campo JM,Prat A,Gil-Moreno A,Pérez J,Parera M

更新日期：2008-09-01 00:00:00