A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

abstract：OBJECTIVE:To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS:This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from pati...

journal_title：Gynecologic oncology

authors： Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

更新日期：2017-06-01 00:00:00

abstract：:The extent to which the antigenic phenotype of human epithelial ovarian cancer changes during the course of the disease is an issue that must be addressed in order to maximize the potential of antibody-directed imaging and therapy. We have obtained tumor specimens at two separate operations from ten patients with epit...

journal_title：Gynecologic oncology

authors： Rubin SC,Finstad CL,Hoskins WJ,Federici MG,Lloyd KO,Lewis JL Jr

更新日期：1989-09-01 00:00:00

abstract：:The oncogene specific mRNA of c-erbB-2 was detected by the S1 nuclease protection assay in 95 ovarian cancer specimens. In 79 primary carcinomas, we found 16 (20%) with strong expression, 13 (17%) with weak expression, 4 (5%) with very weak expression, and 46 (58%) with no expression. In 3 of 16 recurrencies (19%) a s...

journal_title：Gynecologic oncology

authors： Tanner B,Kreutz E,Weikel W,Meinert R,Oesch F,Knapstein PG,Becker R

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:The goal of this work was to test the hypotheses that S-phase fraction (SPF) by DNA labeling index (SPF-LI) would predict the course of the disease for ovarian/peritoneal carcinomas and that SPF-LI would correlate better with pathologic classification and outcome than SPF by DNA flow cytometry (SPF-F). METH...

journal_title：Gynecologic oncology

authors： Meyer JS,Gersell DJ,Yim S

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Our goal was to pragmatically describe patient reported outcomes (PROs) in a typical clinic population of vulvar cancer patients, as prior studies of vulvar cancer PROs have examined clinical trial participants. METHODS:A prospective PRO program was implemented in the Gynecologic Oncology clinic of a tertiar...

journal_title：Gynecologic oncology

authors： Alimena S,Sullivan MW,Philp L,Dorney K,Hubbell H,Del Carmen MG,Goodman A,Bregar A,Growdon WB,Eisenhauer EL,Sisodia RC

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this article is to review the data, rationale, and recommendations of vaginal brachytherapy (VBT) in the post-operative treatment of endometrial cancer patients. METHODS:The authors performed a thorough review of the medical literature regarding the use of adjuvant VBT in the treatment of endo...

journal_title：Gynecologic oncology

authors： Harkenrider MM,Block AM,Siddiqui ZA,Small W Jr

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

journal_title：Gynecologic oncology

authors： English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS:In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and duration of tamoxi...

journal_title：Gynecologic oncology

authors： Robinson DC,Bloss JD,Schiano MA

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

journal_title：Gynecologic oncology

authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Microsatellite instability (MSI) is a frequent genetic event in the D-loop region (which controls mitochondrial DNA (mtDNA) replication) of mitochondrial genome of endometrial cancer. We therefore investigated the relationship between mtMSI and mtDNA content in endometrial cancer. METHODS:Tumor tissues from ...

journal_title：Gynecologic oncology

authors： Wang Y,Liu VW,Xue WC,Tsang PC,Cheung AN,Ngan HY

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:To construct a tool, using computed tomography (CT) imaging and preoperative clinical variables, to estimate successful primary cytoreduction for advanced epithelial ovarian cancer (EOC). METHODS:Women who underwent primary cytoreductive surgery for stage IIIC/IV EOC at Mayo Clinic between 1/2/2003 and 12/3...

journal_title：Gynecologic oncology

authors： Janco JM,Glaser G,Kim B,McGree ME,Weaver AL,Cliby WA,Dowdy SC,Bakkum-Gamez JN

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Primary debulking surgery (PDS) has historically been the standard treatment for advanced ovarian cancer. Recent data appear to support a paradigm shift toward neoadjuvant chemotherapy with interval debulking surgery (NACT-IDS) for a subset of women with advanced ovarian cancer. It remains unresolved whether ...

journal_title：Gynecologic oncology

authors： Rauh-Hain JA,Nitschmann CC,Worley MJ Jr,Bradford LS,Berkowitz RS,Schorge JO,Campos SM,del Carmen MG,Horowitz NS

更新日期：2013-04-01 00:00:00

abstract：:Forty-five patients with invasive cervical squamous cell carcinoma were registered in the Tom Baker Cancer Centre from 1980 to 1985. The natural history of 22 patients (48.9%) who developed persistent or recurrent disease including 11 Stage IB, 8 Stage IIB, and 3 Stage IIIB is reported. Only one patient who had the un...

journal_title：Gynecologic oncology

authors： Stuart GC,Robertson DI,Fedorkow DM,Duggan MA,Nation JG

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:To design and implement a standardized postoperative voiding management protocol that accurately identifies patients with urinary retention and reduces unnecessary re-catheterization. METHODS:A postoperative voiding management protocol was designed and implemented in patients undergoing major, inpatient, non...

journal_title：Gynecologic oncology

authors： Brackmann M,Carballo E,Uppal S,Torski J,Reynolds RK,McLean K

更新日期：2020-05-01 00:00:00

abstract：:The ovary is a relatively frequent site of metastasis from malignant neoplasia arising elsewhere in the body, the majority of these originating from the GI tract. The best known tumor of this type is signet-ring cell adenocarcinoma (Krukenberg tumor) of gastric origin. The gall bladder and bile ducts are rare sources ...

journal_title：Gynecologic oncology

authors： Lashgari M,Behmaram B,Hoffman JS,Garcia J

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the efficacy of a low-dose oral granisetron plus intravenous dexamethasone prophylactic antiemetic regimen in patients receiving carboplatin-based chemotherapy. PATIENTS AND METHODS:Patients with gynecologic malignancies being treated with either single-agent carb...

journal_title：Gynecologic oncology

authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:Serum vascular endothelial growth factor (VEGF) levels have been shown to be associated with an adverse outcome in patients with ovarian cancer. We studied the clinical value of serum VEGF as an independent prognostic parameter. METHODS:In the present study, we ascertained preoperative serum VEGF in a series...

journal_title：Gynecologic oncology

authors： Hefler LA,Zeillinger R,Grimm C,Sood AK,Cheng WF,Gadducci A,Tempfer CB,Reinthaller A

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Intraperitoneal (IP) chemotherapy following neoadjuvant chemotherapy (NACT) and interval tumor reductive surgery (TRS) for advanced ovarian cancer is feasible, however, the impact on disease outcomes remains unclear. We compare outcomes of patients treated with IP chemotherapy versus intravenous (IV) chemoth...

journal_title：Gynecologic oncology

authors： Bixel K,Vetter M,Davidson B,Berchuck A,Cohn D,Copeland L,Fowler JM,Havrilesky L,Lee PS,O'Malley DM,Salani R,Valea F,Alvarez Secord A,Backes F

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To investigate whether the number of lymph nodes obtained during lymphadenectomy affects the survival of patients with intermediate- or high-risk endometrioid-type endometrial cancer. METHODS:A total of 476 patients who were diagnosed with FIGO stage IB to IIIC2 endometrioid adenocarcinoma through surgical s...

journal_title：Gynecologic oncology

authors： Kim TH,Kim HS,Kim TJ,Chang SJ,Kim DY,Ryu SY,Kim BG,Kim YT,Bae DS,Ryu HS,Nam JH

更新日期：2016-06-01 00:00:00

abstract：STUDY OBJECTIVE:To describe our technique for excision of the pre-caval and laterocaval nodes using an extraperitoneal approach. This technique was developed to make the dissection and excision of the less accessible nodes in an easier and safer way by minimizing the risk of great vessels injury and bleeding. DESIGN:S...

journal_title：Gynecologic oncology

authors： Gorostidi M,Villalain C,Ruiz R,Jaunarena I,Lekuona A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Approximately one third of patients treated with methotrexate for gestational trophoblastic neoplasia (GTN) following a molar pregnancy are reported to develop resistance to methotrexate and need to change to different chemotherapeutic agents. Previous studies, in other clinical settings, have suggested that ...

journal_title：Gynecologic oncology

authors： Lasecka L,Dixon PH,Molokhia M,Sharma N,Schleh A,Wang CM,Steel JH,Seckl MJ,Savage PM,Fisher RA

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:To determine prognostic factors for survival in ovarian cancer patients treated with intraperitoneal (IP) chemotherapy using ancillary data from cooperative group clinical trials. METHODS:Data were collected from 428 patients with stage III ovarian cancer who underwent optimal surgical cytoreduction (<1 cm)...

journal_title：Gynecologic oncology

authors： Landrum LM,Java J,Mathews CA,Lanneau GS Jr,Copeland LJ,Armstrong DK,Walker JL

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Protein homeostasis is a highly complex network of molecular interactions governing the health and life span of the organism. Molecular chaperones, mainly heat shock proteins (HSP) and other stress-inducible proteins abundantly expressed in multiple compartments of the cell, are major modulators of protein h...

journal_title：Gynecologic oncology

authors： Landriscina M,Amoroso MR,Piscazzi A,Esposito F

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Approximately 20% of patients receiving platinum-based chemotherapy for epithelial ovarian cancer (EOC) are refractory or develop early recurrence. Identifying these patients early could reduce treatment-associated morbidity and allow quicker transfer to more effective therapies. Much attention has focused on...

journal_title：Gynecologic oncology

authors： Deloia JA,Bhagwat NR,Darcy KM,Strange M,Tian C,Nuttall K,Krivak TC,Niedernhofer LJ

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:This study describes the surgical treatment and follow-up of 213 patients with primary vulvar cancer; particular attention is given to reconstructive surgical procedures. METHODS:The clinical and pathological parameters of the patients were recorded according to standardized procedures, and the data concerni...

journal_title：Gynecologic oncology

authors： Weikel W,Hofmann M,Steiner E,Knapstein PG,Koelbl H

更新日期：2005-10-01 00:00:00

abstract：:Mixed Müllerian tumors (MMT) of the uterus are aggressive entities that result in a very poor prognosis even for patients in whom the disease is limited to the uterus. This phase II trial was undertaken in an attempt to improve overall survival as well as progression-free survival of these patients. Forty-two consecut...

journal_title：Gynecologic oncology

authors： Resnik E,Chambers SK,Carcangiu ML,Kohorn EI,Schwartz PE,Chambers JT

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:The objectives of this study were to estimate the clinical response rate and toxicity of daily tamoxifen combined with intermittent weekly medroxyprogesterone acetate (MPA). METHODS:This study reports the results of 61 patients with measurable advanced or recurrent endometrial carcinoma enrolled on this stu...

journal_title：Gynecologic oncology

authors： Whitney CW,Brunetto VL,Zaino RJ,Lentz SS,Sorosky J,Armstrong DK,Lee RB,Gynecologic Oncology Group study.

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Surgical staging of apparent early stage adnexal carcinoma provides indispensable information. A significant number of patients are referred to tertiary centers with inadequate staging information. We report on our experience with late results of laparoscopic restaging procedure in uncompletely managed early...

journal_title：Gynecologic oncology

authors： Leblanc E,Querleu D,Narducci F,Occelli B,Papageorgiou T,Sonoda Y

更新日期：2004-09-01 00:00:00

abstract：:Ovarian carcinomas of similar histology have variable responses to radiation therapy. It has been suggested that inherent cellular resistance to radiation may in part underlie radiotherapy failure. To determine in vitro radiobiological parameters of papillary serous adenocarcinoma of the ovary, we investigated the cel...

journal_title：Gynecologic oncology

authors： Rotmensch J,Schwartz JL,Atcher RW,Grdina DJ,Toohill M,Weichselbaum RW

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. METHODS:Women, age 40 and older, with BRCA mutations identified in Kaiser Permanente Northern California completed a questionnaire and underwent a lipid and fasting glucose panel. Bivariable analysis of...

journal_title：Gynecologic oncology

authors： Powell CB,Alabaster A,Armstrong MA,Stoller N,Raine-Bennett T

更新日期：2018-12-01 00:00:00