Abstract:
:Nuclei of cells infected with Moloney murine leukemia virus (MoMuLV) were examined for the presence of gag proteins. This analysis was performed in conjunction with other studies suggesting a possible role for gag proteins in regulating nuclear events relating to processing and/or transport of viral genomic RNA. We detected Pr65gag and a p30-related protein in a nuclear fraction of infected cells. We also found evidence that a highly conserved amino acid sequence, which is shared by p30 and U1 small nuclear ribonucleoprotein 70-kDa protein, is a component of the nuclear targeting sequence for Pr65gag. Immunoelectron microscopy studies with a monoclonal anti-p12 antibody established that approximately 18% of gag-containing proteins of MoMuLV are located in the nucleus. Such gag-containing proteins from a mutant MoMuLV that lacks N-terminal myristic acid had greater affinity for the nucleus, suggesting that fatty acid acylation of Pr65gag plays a role in overcoming the proposed nuclear transport signal. The possible roles that nuclear gag proteins may play in retroviral replication are discussed.
journal_name
J Viroljournal_title
Journal of virologyauthors
Nash MA,Meyer MK,Decker GL,Arlinghaus RBdoi
10.1128/JVI.67.3.1350-1356.1993subject
Has Abstractpub_date
1993-03-01 00:00:00pages
1350-6issue
3eissn
0022-538Xissn
1098-5514journal_volume
67pub_type
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
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更新日期:1972-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,收录出版
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更新日期:2010-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.11.1.46-53.1973
更新日期:1973-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.4.1859-1860.1990
更新日期:1990-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
abstract::Varicella-zoster virus (VZV) causes varicella and establishes latency in sensory nerve ganglia, but the characteristics of VZV latency are not well defined. Immunohistochemical detection of the VZV immediate-early 63 (IE63) protein in ganglion neurons has been described, but there are significant discrepancies in esti...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2020-11-23 00:00:00