Abstract：
OBJECTIVE:The clinical use of aminoglycoside antibiotics is limited in most countries because of auditory toxicity side effects. However, their use is common in developing countries because they are inexpensive and convenient. Salvia miltiorrhiza extracts are used clinically in China for their antioxidant properties. We investigated the effect of a clinically approved injectable S. miltiorrhiza solution on inducible nitric oxide synthase (iNOS) generation induced by the aminoglycoside antibiotic gentamicin and an ototoxicity protective mechanism. METHODS:Sixty adult guinea pigs were used in this study and divided into four groups. Auditory brainstem response (ABR) testing was performed before and after treatments and animals were sacrificed for morphological and immunostaining assays after determining threshold shifts in ABR. The cochleae were examined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) to observe ultrastructural changes. In addition, hair cell loss, iNOS and caspase-3 expression, and apoptosis were measured. RESULTS:The result showed that hearing loss, iNOS overexpression accompanied with disorganization in the cochlea, and terminal deoxynucleotidyl transferase- mediated dUTP- biotin nick end labeling (TUNEL)-stained positive cells in animals treated with gentamicin. However, pretreatment with S. miltiorrhiza (3g/kg/day for 10 days) decreased gentamicin-induced hearing loss, attenuated iNOS and caspase-3 expression, and decreased the number of apoptotic cells. Furthermore, it also reduced the ultrastructural damage due to ototoxicity as observed by SEM and TEM. CONCLUSIONS:These findings indicate that S. miltiorrhiza protects against gentamicin-induced ototoxicity and could apply to the protection of ototoxicity.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Shi L,An Y,Wang A,Gao Q,Yang Ydoi
10.1016/j.amjoto.2013.08.022subject
Has Abstractpub_date
2014-03-01 00:00:00pages
171-9issue
2eissn
0196-0709issn
1532-818Xpii
S0196-0709(13)00215-9journal_volume
35pub_type
杂志文章abstract：:This case report describes a patient who was found to have a cerebrospinal fluid (CSF) leak originating from the petrous apex. The patient initially presented with multiple bouts of meningitis. The patient was treated surgically via a middle cranial fossa approach but presented five years later with recurrent meningit...
journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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journal_title：American journal of otolaryngology
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doi：10.1016/j.amjoto.2018.03.005
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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doi：10.1016/0196-0709(91)90119-z
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2009.11.002
更新日期：2011-03-01 00:00:00
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(80)80036-6
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,多中心研究
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journal_title：American journal of otolaryngology
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doi：10.1016/j.amjoto.2006.12.006
更新日期：2008-01-01 00:00:00
