Abstract：
:Carbonic anhydrase appears to be involved in the process of otoconial formation. The purpose of this investigation was to observe the morphologic change in the surface structure of the otolithic organ in developing chick embryos after injection of the carbonic anhydrase inhibitor, acetazolamide. Acetazolamide (1.5, 3, or 6 mg/0.06 mL/egg) was injected into the yolk sac of the embryo of the fifth day of incubation. Embryo specimens were collected on the 11th, 13th, and 18th days of incubation. The chicks were killed on the third day posthatching, and the surfaces of the otolithic organs were observed under a scanning electron microscope. A marked disturbance in otoconial formation was noted in both utricle and saccule, marked by a decrease or absence of otoconia. A widely exposed meshwork structure of otolithic membrane was observed, with sensory cilia penetrating the meshwork small holes in many instances. There were also several otoconial abnormalities, such as the appearance of only a single giant otoconium, or from several to dozens of giant otoconia, and rough, spongy-surfaced global substances entirely covering the maculae. Clearly, carbonic anhydrase inhibitor (acetazolamide) injected into the yolk sac of developing chick embryos alters and inhibits normal otoconial morphogenesis.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Kido T,Sekitani T,Yamashita H,Endo S,Masumitsu Y,Shimogori Hdoi
10.1016/0196-0709(91)90119-zsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
191-5issue
4eissn
0196-0709issn
1532-818Xpii
0196-0709(91)90119-Zjournal_volume
12pub_type
杂志文章abstract：PURPOSE:To assess malpractice claims related to the management of dizziness in otolaryngology in order to improve care and minimize the risk of litigation. MATERIALS AND METHODS:This is a retrospective review of the LexisNexis "Jury Verdicts and Settlements" database. All lawsuits and out of court adjudications relate...
journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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更新日期：2009-11-01 00:00:00
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更新日期：2015-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2006-03-01 00:00:00
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更新日期：2016-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：1985-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：American journal of otolaryngology
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pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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更新日期：2005-07-01 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：2003-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
abstract：:We aimed to investigate the relationship between peripheral vertigo and inflammation by using the neutrophil-to-lymphocyte ratio (NLR) as an inflammatory marker. We recruited 103 patients with peripheral vertigo (71 women, 32 men; mean age, 39.8 ± 14.7 years) who presented to the Otolaryngology Department of Dumlupina...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2002-05-01 00:00:00
