Abstract：
PURPOSE:Chronic tonsillitis (TC) is among the most common bacterial diseases in pediatric otolaryngology. We aimed to evaluate the expression of glycogen synthase kinase 3β (GSK-3β) in a cohort of children with chronic tonsillitis (TC), and the correlation between GSK-3β activity index and inflammatory profiles of TC. MATERIALS AND METHODS:The expression of GSK-3β was comparably evaluated between children with TC (n = 26) and tonsillar hypertrophy (TH, n = 26). GSK-3β expression was detected by immunohistochemistry, RT-qPCR, and Western blot. The inflammatory profiles between the TC and TH groups were also evaluated. RESULTS:We found that while GSK-3β was highly expressed in both TC and TH groups, no significant difference were detected at mRNA and protein levels between groups. The protein level of p-GSK-3β was significantly lower in the TC group as compared to the TH group. Additionally, the inflammatory markers, including NF-κB, T-bet, and IFN-γ were higher in the TC group compared to TH group. The GSK-3β activation index was positively correlated with the levels of NF-κB, T-bet, and IFN-γ in the TC group. CONCLUSIONS:Our findings suggested that GSK-3β activation index was demonstrated to be a clinically applicable indicator for chronic recurrent inflammation in pediatric TC.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Gao Y,Mi J,Chen F,Liao Z,Feng X,Lv M,He H,Cao Y,Yan Y,Zhu Z,Fan Y,Hong Hdoi
10.1016/j.amjoto.2018.03.005subject
Has Abstractpub_date
2018-01-01 00:00:00pages
277-281issue
3eissn
0196-0709issn
1532-818Xpii
S0196-0709(18)30001-2journal_volume
39pub_type
杂志文章abstract：:Divided nevus, which is also known as "kissing nevus," "split ocular nevus" and "panda nevus" is a rare congenital dermatological abnormality that occurs on opposing margins of upper and lower eyelids. There is a paucity of literature on this rare anomaly, with most knowledge from this disease process derived from iso...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.amjoto.2013.01.004
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:To quantify the incidence of ear disease in patients infected with human immunodeficiency virus (HIV). MATERIALS AND METHODS:This is a descriptive case series of HIV-positive patients, with data collected using an otologic questionnaire. otologic examination, audiologic evaluation, and chart review. The study ...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
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更新日期：2020-01-01 00:00:00
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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journal_title：American journal of otolaryngology
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更新日期：2014-05-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2012.08.005
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journal_title：American journal of otolaryngology
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更新日期：2020-01-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2006-05-01 00:00:00
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journal_title：American journal of otolaryngology
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更新日期：2019-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(83)80013-1
更新日期：1983-03-01 00:00:00
abstract：:Carbonic anhydrase appears to be involved in the process of otoconial formation. The purpose of this investigation was to observe the morphologic change in the surface structure of the otolithic organ in developing chick embryos after injection of the carbonic anhydrase inhibitor, acetazolamide. Acetazolamide (1.5, 3,...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
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journal_title：American journal of otolaryngology
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journal_title：American journal of otolaryngology
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pub_type： 杂志文章
doi：10.1053/ajot.2003.2
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
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更新日期：1995-05-01 00:00:00
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journal_title：American journal of otolaryngology
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doi：10.1016/j.amjoto.2013.02.004
更新日期：2013-09-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjoto.2006.06.016
更新日期：2007-03-01 00:00:00
abstract：:Leiomyosarcoma of the paranasal sinuses is uncommon and has an aggressive clinical behavior. Only 28 cases have been described in the literature, and, of these, only 3 patients treated with surgery had a disease-free survival. In this report, we describe the clinical history of a 57-year-old woman with a leiomyosarcom...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1053/ajot.2002.30628
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:The goal of this study is to describe a unique finding of ulcerative lesions of the larynx in two pediatric patients presenting with prolonged acute laryngotracheitis and compare to previously described reports to determine the typical clinical picture, need for intervention, and management model. METHODS:We...
journal_title：American journal of otolaryngology
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更新日期：2013-09-01 00:00:00
abstract：PURPOSE:Low numbers of primary auditory neurons (ANs) may compromise the clinical performance of a cochlear implant. The focus of this research is to determine whether stem cells can be used to replace the ANs lost following deafness. To successfully replace these neurons, stem cells must be capable of directed differe...
journal_title：American journal of otolaryngology
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更新日期：2012-01-01 00:00:00
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journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/j.amjoto.2017.03.008
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:To investigate the activities of inner ear melanin in patients with pigment variations and disorders. Our purpose was to find evidence on the effects of melanin-containing cells by measuring the high-frequency threshold and the latency of stapes reflex in patients with vitiligo. PATIENTS AND METHODS:Twenty-nin...
journal_title：American journal of otolaryngology
pub_type： 杂志文章
doi：10.1016/s0196-0709(98)90038-2
更新日期：1998-11-01 00:00:00
abstract：:Histiocytic necrotizing lymphadenitis (HNL) also known as Kikuchi or Kikuchi-Fujimato disease is a benign and self-limiting disease. The entity was first described in 1972 by Kikuchi and Fujimato in Japan independently. HNL is prevalent in Asia, although it may be seen in a wide geographic distribution. It commonly af...
journal_title：American journal of otolaryngology
pub_type： 杂志文章,评审
doi：10.1016/s0196-0709(03)00061-9
更新日期：2003-09-01 00:00:00
