Transcriptional coupling of DNA repair in sporulating Bacillus subtilis cells.

abstract：:Toxin-antitoxin loci have been identified in almost all free-living prokaryotes, often in high copy numbers. The biological function and molecular targets of the abundant vapBC loci are not yet known. Here we analyse the vapBC loci of Salmonella LT2 and Shigella plasmid pMYSH6000. Both loci encode putative PIN (PilT N...

journal_title：Molecular microbiology

authors： Winther KS,Gerdes K

更新日期：2009-05-01 00:00:00

abstract：:Strains of Rhizobium leguminosarum biovar viciae specifically make an abundant protein (Rhi) in free-living culture but not in bacteroids. Genes needed for Rhi synthesis are on a Sym plasmid and here we show that one of these genes, rhiA, is the structural gene that specifies this polypeptide. Transcription of rhiA re...

journal_title：Molecular microbiology

authors： Economou A,Hawkins FK,Downie JA,Johnston AW

更新日期：1989-01-01 00:00:00

abstract：:Bacterial secretion systems often employ molecular chaperones to recognize and facilitate export of their substrates. Recent work demonstrated that a secreted component of the type VI secretion system (T6SS), haemolysin co-regulated protein (Hcp), binds directly to effectors, enhancing their stability in the bacterial...

journal_title：Molecular microbiology

authors： Whitney JC,Beck CM,Goo YA,Russell AB,Harding BN,De Leon JA,Cunningham DA,Tran BQ,Low DA,Goodlett DR,Hayes CS,Mougous JD

更新日期：2014-05-01 00:00:00

abstract：:mscL encodes a channel in Escherichia coli that is opened by membrane stretch force, probably serving as an osmotic gauge. Sequences more or less similar to mscL are found in other bacteria, but the degree of conserved function has been unclear. We subcloned and expressed these putative homologues in E. coli and exami...

journal_title：Molecular microbiology

authors： Moe PC,Blount P,Kung C

更新日期：1998-05-01 00:00:00

abstract：:CS1 pili are filamentous proteinaceous appendages found on many enterotoxigenic Escherichia coli (ETEC) strains isolated from human diarrhoeal disease. They are thought to effect colonization of the upper intestine by facilitating binding to human ileal epithelial cells. We have identified a gene, cooB, which lies dir...

journal_title：Molecular microbiology

authors： Scott JR,Wakefield JC,Russell PW,Orndorff PE,Froehlich BJ

更新日期：1992-02-01 00:00:00

abstract：:Bacterial autotransporters consist of an N-terminal 'passenger domain' that is transported into the extracellular space by an unknown mechanism and a C-terminal 'beta-domain' that forms a beta-barrel in the outer membrane. Recent studies have revealed that fully assembled autotransporters have an unusual architecture ...

journal_title：Molecular microbiology

authors： Ieva R,Skillman KM,Bernstein HD

更新日期：2008-01-01 00:00:00

abstract：:Copy-number mutants of Staphylococcus aureus macrolide-lincosamide-streptogramin B (MLS) resistance plasmid pT48 were isolated by their resistance to the non-inducing macrolide, tylosin. One mutant plasmid, pcopD3, showed a three- to five-fold cis-dominant increase in copy number, and nucleotide sequence analysis reve...

journal_title：Molecular microbiology

authors： Catchpole I,Dyke KG

更新日期：1991-04-01 00:00:00

abstract：:The aroA gene from Pasteurella multocida was cloned by complementation of the Escherichia coli aroA mutant AB2829 with a DNA library constructed in pUC18. The nucleotide sequence of the P. multocida aroA gene indicated an open reading frame encoding a protein of 441 amino acids, which showed a high degree of homology ...

journal_title：Molecular microbiology

authors： Homchampa P,Strugnell RA,Adler B

更新日期：1992-12-01 00:00:00

abstract：:Transmission of Plasmodium species from a mammalian host to the mosquito vector requires the uptake, during an infected blood meal, of gametocytes, the precursor cells of the gametes. Relatively little is known about the molecular mechanisms involved in the developmental switch from asexual development to sexual diffe...

journal_title：Molecular microbiology

authors： Boisson B,Lacroix C,Bischoff E,Gueirard P,Bargieri DY,Franke-Fayard B,Janse CJ,Ménard R,Baldacci P

更新日期：2011-09-01 00:00:00

abstract：:The translational roles of the Shine-Dalgarno sequence, the initiation codon, the space between them, and the second codon have been studied. The Shine-Dalgarno sequence UAAGGAGG initiated translation roughly four times more efficiently than did the shorter AAGGA sequence. Each Shine-Dalgarno sequence required a minim...

journal_title：Molecular microbiology

authors： Ringquist S,Shinedling S,Barrick D,Green L,Binkley J,Stormo GD,Gold L

更新日期：1992-05-01 00:00:00

abstract：:Initiation of Escherichia coli chromosome replication is controlled by the DnaA initiator protein. Both rifampicin-mediated inhibition of transcription and ppGpp-induced changes in global transcription stops replication at the level of initiation. Here, we show that continued DnaA protein synthesis allows for replicat...

journal_title：Molecular microbiology

authors： Riber L,Løbner-Olesen A

更新日期：2020-12-01 00:00:00

abstract：:Histidine kinases function as dimers. The kinase domain of the osmosensing histidine kinase EnvZ of Escherichia coli consists of two domains: domain A (67 residues) responsible for histidine phosphotransfer and dimerization, and domain B (161 residues) responsible for the catalytic and ATP-binding function. The indivi...

journal_title：Molecular microbiology

authors： Qin L,Dutta R,Kurokawa H,Ikura M,Inouye M

更新日期：2000-04-01 00:00:00

abstract：:Sinorhizobium meliloti is a soil bacterium that invades the root nodules it induces on Medicago sativa, whereupon it undergoes an alteration of its cell cycle and differentiates into nitrogen-fixing, elongated and polyploid bacteroid with higher membrane permeability. In Caulobacter crescentus, a related alphaproteoba...

journal_title：Molecular microbiology

authors： Pini F,Frage B,Ferri L,De Nisco NJ,Mohapatra SS,Taddei L,Fioravanti A,Dewitte F,Galardini M,Brilli M,Villeret V,Bazzicalupo M,Mengoni A,Walker GC,Becker A,Biondi EG

更新日期：2013-10-01 00:00:00

abstract：:The Streptomyces wild-type chromosome is linear in all examples studied. The ends of the chromosome or telomeres consist of terminal inverted repeats of various sizes with proteins covalently bound to their 5' ends. The chromosome is very unstable and undergoes very large deletions spontaneously at rates higher than 0...

journal_title：Molecular microbiology

authors： Volff JN,Altenbuchner J

更新日期：1998-01-01 00:00:00

abstract：:Fungi capable of sexual reproduction use heterothallic (self-sterile) or homothallic (self-fertile) mating strategies. In most ascomycetes, a single mating type locus, MAT, with two alternative forms (MAT1-1 and MAT1-2) called idiomorphs, controls mating ability. In heterothallic ascomycetes, these alternative idiomor...

journal_title：Molecular microbiology

authors： Lee J,Lee T,Lee YW,Yun SH,Turgeon BG

更新日期：2003-10-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are persistent and toxic environmental pollutants that accumulate in anoxic habitats. With the exception of naphthalene, nothing is known about the microbial degradation of PAH in these environments. The challenge that must be met in anaerobic PAH degradation is the destabilizat...

journal_title：Molecular microbiology

authors： Sawers RG

更新日期：2015-01-01 00:00:00

abstract：:The K1 killer toxin of Saccharomyces cerevisiae consists of 103- and 83-residue alpha and beta components whose derivation, from a 316-residue precursor preprotoxin, requires processing at the alpha N-terminus (after ProArg-44), the alpha C-terminus (after ArgArg-149) and at the beta N-terminus (after LysArg-233). The...

journal_title：Molecular microbiology

authors： Zhu YS,Zhang XY,Cartwright CP,Tipper DJ

更新日期：1992-02-01 00:00:00

abstract：:Reverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli. The gene for reverse transcriptase is part of a chromosomal genetic element that codes for the production o...

journal_title：Molecular microbiology

authors： Lim D,Maas WK

更新日期：1989-08-01 00:00:00

abstract：:Bacteria harbour both ferrous and ferric iron transporters. We now report that infection of macrophages and mice with a Salmonella enterica Typhimurium strain containing an inactivated feoB-encoded ferrous iron transporter results in increased bacterial replication, compared to infection with wild type. Inactivation o...

journal_title：Molecular microbiology

authors： Nagy TA,Moreland SM,Detweiler CS

更新日期：2014-09-01 00:00:00

abstract：:The Escherichia coli marRAB operon specifies two regulatory proteins, MarR (which represses) and MarA (which activates expression of the operon). The latter controls expression of multiple other chromosomal genes implicated in cell physiology, multiple drug resistance and virulence. Using randomly cloned E. coli DNA f...

journal_title：Molecular microbiology

authors： Domain F,Bina XR,Levy SB

更新日期：2007-10-01 00:00:00

abstract：:Periplasmic Cu,Zn-superoxide dismutases (Cu,Zn-SODs) are implicated in bacterial virulence. It has been proposed that some bacterial P(1B)-type ATPases supply copper to periplasmic cupro-proteins and such transporters have also been implicated in virulence. Here we show that either of two P(1B)-type ATPases, CopA or G...

journal_title：Molecular microbiology

authors： Osman D,Patterson CJ,Bailey K,Fisher K,Robinson NJ,Rigby SE,Cavet JS

更新日期：2013-02-01 00:00:00

abstract：:Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of fungal growth and contribute to serious health problems in the developing world because of their toxicity and mutagenicity. Although relatively resistant to biotic degradation, aflatoxins can be metabolized by certain species ...

journal_title：Molecular microbiology

authors： Taylor MC,Jackson CJ,Tattersall DB,French N,Peat TS,Newman J,Briggs LJ,Lapalikar GV,Campbell PM,Scott C,Russell RJ,Oakeshott JG

更新日期：2010-11-01 00:00:00

abstract：:The rotA gene of Escherichia coli encodes a peptidyl-prolyl cis/trans isomerase (PPIase), which is supposed to catalyse protein folding in the periplasm. To investigate the importance of the enzyme, the rotA gene was cloned and a chromosomal deletion mutant was created. The rotA mutant was normally viable. No residual...

journal_title：Molecular microbiology

authors： Kleerebezem M,Heutink M,Tommassen J

更新日期：1995-10-01 00:00:00

abstract：:In bacteria, genes are often expressed from multiple promoters to allow for a greater spectrum of regulation. Transcription of rRNA genes in Escherichia coli uses two promoters, rrn P1 and rrn P2. Under the conditions examined previously, the P1 and P2 promoters were regulated in response to many of the same changes i...

journal_title：Molecular microbiology

authors： Murray HD,Gourse RL

更新日期：2004-06-01 00:00:00

abstract：:Ethylenediaminetetraacetate (EDTA) is currently the most abundant organic pollutant due to its recalcitrance and extensive use. Only a few bacteria can degrade it, using EDTA monooxygenase (EmoA) to initiate the degradation. EmoA is an FMNH2 -dependent monooxygenase that requires an NADH:FMN oxidoreductase (EmoB) to p...

journal_title：Molecular microbiology

authors： Jun SY,Lewis KM,Youn B,Xun L,Kang C

更新日期：2016-06-01 00:00:00

abstract：:In F. graminearum, the transcription factor TRI6 positively regulates the trichothecene biosynthetic gene cluster (BGC) leading to the production of the secondary metabolite 15-acetyl deoxynivalenol. Secondary metabolites are not essential for survival, instead, they enable the pathogen to successfully infect its host...

journal_title：Molecular microbiology

authors： Shostak K,Bonner C,Sproule A,Thapa I,Shields SWJ,Blackwell B,Vierula J,Overy D,Subramaniam R

更新日期：2020-10-01 00:00:00

abstract：:This past January, in Cuernavaca Mexico, a conglomerate of scientists met to discuss the contemporary view of Bacterial Locomotion and Signal Transduction (BLAST). The BLAST meetings represent a field that has its roots in chemotaxis and the flagellum-based motility but now encompass all types of cellular movement and...

journal_title：Molecular microbiology

authors： Scharf BE,Aldridge PD,Kirby JR,Crane BR

更新日期：2009-07-01 00:00:00

abstract：:During Bacillus subtilis endospore formation, a complex protein coat is assembled around the maturing spore. The coat is made up of more than two dozen proteins that form an outer layer, which provides chemical resistance, and an inner layer, which may play a role in the activation of germination. A third, amorphous l...

journal_title：Molecular microbiology

authors： Seyler RW Jr,Henriques AO,Ozin AJ,Moran CP Jr

更新日期：1997-09-01 00:00:00

abstract：:Magnetotactic bacteria contain nanometre-sized, membrane-bound organelles, called magnetosomes, which are tasked with the biomineralization of small crystals of the iron oxide magnetite allowing the organism to use geomagnetic field lines for navigation. A key player in this process is the HtrA/DegP family protease Ma...

journal_title：Molecular microbiology

authors： Quinlan A,Murat D,Vali H,Komeili A

更新日期：2011-05-01 00:00:00

abstract：:Several bacterial genera express proteins that contain collagen-like regions, which are associated with variable (V) non-collagenous regions. The streptococcal collagen-like proteins, Scl1 and Scl2, of group A Streptococcus (GAS) are members of this 'prokaryotic collagen' family, and they too contain an amino-terminal...

journal_title：Molecular microbiology

authors： Han R,Caswell CC,Lukomska E,Keene DR,Pawlowski M,Bujnicki JM,Kim JK,Lukomski S

更新日期：2006-07-01 00:00:00