Abstract:
:We report a novel one-stage technique of total hepatectomy in the rat, in which the liver is replaced by an autologous prosthesis. This prosthesis is obtained from a donor rat, and consists of the subhepatic vena cava and the left renal vein harvested en block. This graft is sutured with the subdiaphragmatic cava and linked with cuffs to the subhepatic vena cava and the portal vein in the donor rat. This procedure is associated with a very low operative mortality. Rats with glucose and plasma-expander infusions survived for a mean time of 23 +/- 9 hr. This technique of total hepatectomy can be considered a valid and reproducible model of true anhepaty for metabolic and survival studies with liver support systems.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Lorenzo M,Angrisani L,Ventriglia R,Ismail T,Tesauro Bdoi
10.1002/micr.1920160711subject
Has Abstractpub_date
1995-01-01 00:00:00pages
493-5issue
7eissn
0738-1085issn
1098-2752journal_volume
16pub_type
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