Abstract:
:We evaluated blood flow changes after experimental free tissue transfer and the potential hemodynamic effect of sildenafil on the free flap. Sixteen swine were used for free transfer of a latissimus dorsi myocutaneous flap to the chest that was anastomosed to the internal mammary vessels, and were randomized into controls and study group. The latter received a single dose of sildenafil, 6 hours following flap revascularization. Doppler ultrasonography revealed that arterial flow was mainly systolic postoperatively. Diastolic flow patterns were gradually restored after the first postoperative day. Pulsatility index (PI) significantly increased and flow volume decreased in all animals postoperatively. In the sildenafil group, PI significantly decreased and flow volume increased, while diastolic flow patterns were restored earlier on compared to controls, postoperatively. In conclusion, the administration of sildenafil after free tissue transfer increases flow volume and facilitates the restoration of diastolic blood flow patterns in the early critical postoperative period.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Gravvanis A,Papalois A,Delikonstantinou I,Pentilas N,Zogogiannis I,Tsoutsos D,Karakitsos Ddoi
10.1002/micr.20909subject
Has Abstractpub_date
2011-09-01 00:00:00pages
465-71issue
6eissn
0738-1085issn
1098-2752journal_volume
31pub_type
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