Abstract:
:The single-anastomosis heart-lung transplantation method in the rat developed by Lee and associates has been examined and has proven to be simple and reproducible. Technical procedures are discussed emphasizing those procedures that require special caution to ensure successful graft function. The donor and recipient rat strain combination has been found to influence the success of the transplantation procedure. Rat strain combinations used in our laboratories resulted in different percentages of donor heart survival. Using Lewis rat (RT1 1/1) recipients, 68% of Brown Norway rat (RT1n/n) donor hearts and 97% of NBR rat (RT1 1/1) donor hearts survived. However, only 29% of Fischer rat (RT1 1/1) donor hearts survived longer than 2 days when transplanted into Lewis rat recipients. In our laboratories, the Lee method of single-anastomosis heart-lung transplantation has been used successfully to evaluate whether immunoregulatory compounds alter heart allograft rejection.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Scott MH,D'Silva M,Gaarde WA,Leisten JC,Sadoff JA,Axtelle TS,Hahn GS,Plummer JM,Chang ES,Lee Sdoi
10.1002/micr.1920080411subject
Has Abstractpub_date
1987-01-01 00:00:00pages
225-9issue
4eissn
0738-1085issn
1098-2752journal_volume
8pub_type
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