Abstract:
:To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Sun L,Li Y,Shi J,Wang X,Wang Xdoi
10.1002/micr.10058subject
Has Abstractpub_date
2002-01-01 00:00:00pages
343-6issue
8eissn
0738-1085issn
1098-2752journal_volume
22pub_type
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