Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.

Abstract:

:To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.

journal_name

Microsurgery

journal_title

Microsurgery

authors

Sun L,Li Y,Shi J,Wang X,Wang X

doi

10.1002/micr.10058

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

343-6

issue

8

eissn

0738-1085

issn

1098-2752

journal_volume

22

pub_type

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