Abstract:
:We have developed a chitosan/polyglycolic acid (PGA) artificial nerve graft which was previously used for bridge implantation of dog sciatic nerves across 30-mm long defects. Here we describe a clinical trial of this graft for repairing a 35-mm-long median nerve defect at elbow of a human patient. During the 3-year follow-up period, functional recovery of the injured median nerve was assessed by pinch gauge test, hydraulic hand dynamometry, static two-point discrimination and touch test with monofilaments, in couple with electrophysiological examinations. The motor and sensory function of the median nerve demonstrated an ongoing recovery postimplantation, reaching M4 and S3+ levels during the follow-up period. The results indicate that the chitosan/PGA artificial nerve graft could be used for surgical repair of larger defects in major peripheral nerves at a higher level in the human.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Fan W,Gu J,Hu W,Deng A,Ma Y,Liu J,Ding F,Gu Xdoi
10.1002/micr.20488subject
Has Abstractpub_date
2008-01-01 00:00:00pages
238-42issue
4eissn
0738-1085issn
1098-2752journal_volume
28pub_type
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